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Gene: STK38 |
Gene summary for STK38 |
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Gene information | Species | Human | Gene symbol | STK38 | Gene ID | 11329 |
Gene name | serine/threonine kinase 38 | |
Gene Alias | NDR | |
Cytomap | 6p21.31 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | A0A024RD18 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11329 | STK38 | PTC03 | Human | Thyroid | PTC | 2.51e-05 | 1.26e-01 | 0.1784 |
11329 | STK38 | PTC04 | Human | Thyroid | PTC | 1.09e-06 | 8.23e-02 | 0.1927 |
11329 | STK38 | PTC05 | Human | Thyroid | PTC | 4.07e-07 | 2.04e-01 | 0.2065 |
11329 | STK38 | PTC06 | Human | Thyroid | PTC | 1.16e-11 | 2.12e-01 | 0.2057 |
11329 | STK38 | PTC07 | Human | Thyroid | PTC | 7.86e-04 | 1.13e-01 | 0.2044 |
11329 | STK38 | ATC09 | Human | Thyroid | ATC | 1.54e-03 | 8.72e-02 | 0.2871 |
11329 | STK38 | ATC11 | Human | Thyroid | ATC | 2.14e-02 | 2.48e-01 | 0.3386 |
11329 | STK38 | ATC12 | Human | Thyroid | ATC | 9.73e-10 | 1.52e-01 | 0.34 |
11329 | STK38 | ATC13 | Human | Thyroid | ATC | 4.26e-58 | 1.06e+00 | 0.34 |
11329 | STK38 | ATC1 | Human | Thyroid | ATC | 4.91e-03 | 9.31e-02 | 0.2878 |
11329 | STK38 | ATC2 | Human | Thyroid | ATC | 1.78e-16 | 1.17e+00 | 0.34 |
11329 | STK38 | ATC3 | Human | Thyroid | ATC | 1.78e-02 | 1.95e-01 | 0.338 |
11329 | STK38 | ATC4 | Human | Thyroid | ATC | 1.54e-16 | 2.44e-01 | 0.34 |
11329 | STK38 | ATC5 | Human | Thyroid | ATC | 3.55e-69 | 1.15e+00 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00719007 | Cervix | CC | regulation of protein serine/threonine kinase activity | 75/2311 | 359/18723 | 2.76e-06 | 8.02e-05 | 75 |
GO:005134810 | Cervix | CC | negative regulation of transferase activity | 60/2311 | 268/18723 | 2.77e-06 | 8.02e-05 | 60 |
GO:004593610 | Cervix | CC | negative regulation of phosphate metabolic process | 88/2311 | 441/18723 | 2.92e-06 | 8.27e-05 | 88 |
GO:001056310 | Cervix | CC | negative regulation of phosphorus metabolic process | 88/2311 | 442/18723 | 3.21e-06 | 8.77e-05 | 88 |
GO:004232610 | Cervix | CC | negative regulation of phosphorylation | 77/2311 | 385/18723 | 1.09e-05 | 2.38e-04 | 77 |
GO:000193310 | Cervix | CC | negative regulation of protein phosphorylation | 69/2311 | 342/18723 | 2.29e-05 | 4.01e-04 | 69 |
GO:000646910 | Cervix | CC | negative regulation of protein kinase activity | 47/2311 | 212/18723 | 4.13e-05 | 6.36e-04 | 47 |
GO:00181057 | Cervix | CC | peptidyl-serine phosphorylation | 63/2311 | 315/18723 | 6.65e-05 | 9.47e-04 | 63 |
GO:00336739 | Cervix | CC | negative regulation of kinase activity | 50/2311 | 237/18723 | 9.22e-05 | 1.21e-03 | 50 |
GO:00182096 | Cervix | CC | peptidyl-serine modification | 66/2311 | 338/18723 | 9.58e-05 | 1.25e-03 | 66 |
GO:00434099 | Cervix | CC | negative regulation of MAPK cascade | 37/2311 | 180/18723 | 1.17e-03 | 9.50e-03 | 37 |
GO:0010563 | Colorectum | AD | negative regulation of phosphorus metabolic process | 130/3918 | 442/18723 | 1.26e-05 | 2.76e-04 | 130 |
GO:0045936 | Colorectum | AD | negative regulation of phosphate metabolic process | 129/3918 | 441/18723 | 1.81e-05 | 3.76e-04 | 129 |
GO:0051348 | Colorectum | AD | negative regulation of transferase activity | 85/3918 | 268/18723 | 2.07e-05 | 4.19e-04 | 85 |
GO:0042326 | Colorectum | AD | negative regulation of phosphorylation | 112/3918 | 385/18723 | 8.02e-05 | 1.27e-03 | 112 |
GO:0001933 | Colorectum | AD | negative regulation of protein phosphorylation | 101/3918 | 342/18723 | 9.39e-05 | 1.42e-03 | 101 |
GO:0043409 | Colorectum | AD | negative regulation of MAPK cascade | 57/3918 | 180/18723 | 4.61e-04 | 5.14e-03 | 57 |
GO:0006469 | Colorectum | AD | negative regulation of protein kinase activity | 65/3918 | 212/18723 | 5.21e-04 | 5.62e-03 | 65 |
GO:0033673 | Colorectum | AD | negative regulation of kinase activity | 71/3918 | 237/18723 | 6.18e-04 | 6.47e-03 | 71 |
GO:0018105 | Colorectum | AD | peptidyl-serine phosphorylation | 88/3918 | 315/18723 | 1.73e-03 | 1.43e-02 | 88 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STK38 | SNV | Missense_Mutation | novel | c.160N>A | p.Glu54Lys | p.E54K | Q15208 | protein_coding | tolerated(0.16) | benign(0.005) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
STK38 | SNV | Missense_Mutation | novel | c.1255N>G | p.Leu419Val | p.L419V | Q15208 | protein_coding | tolerated(0.3) | benign(0.158) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STK38 | SNV | Missense_Mutation | novel | c.379N>C | p.Glu127Gln | p.E127Q | Q15208 | protein_coding | tolerated(0.16) | benign(0.362) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
STK38 | SNV | Missense_Mutation | c.601G>T | p.Asp201Tyr | p.D201Y | Q15208 | protein_coding | deleterious(0) | possibly_damaging(0.781) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
STK38 | SNV | Missense_Mutation | c.639N>G | p.Ile213Met | p.I213M | Q15208 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-EK-A2RK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
STK38 | SNV | Missense_Mutation | c.766N>A | p.Asp256Asn | p.D256N | Q15208 | protein_coding | tolerated(0.23) | probably_damaging(0.969) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
STK38 | SNV | Missense_Mutation | c.1069A>G | p.Ile357Val | p.I357V | Q15208 | protein_coding | tolerated(0.09) | benign(0.192) | TCGA-AA-3856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
STK38 | SNV | Missense_Mutation | c.813N>C | p.Trp271Cys | p.W271C | Q15208 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AZ-6599-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
STK38 | SNV | Missense_Mutation | c.562N>A | p.Glu188Lys | p.E188K | Q15208 | protein_coding | tolerated(0.86) | benign(0.01) | TCGA-CK-4950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folfox | SD | |
STK38 | SNV | Missense_Mutation | c.457T>C | p.Phe153Leu | p.F153L | Q15208 | protein_coding | deleterious(0.01) | possibly_damaging(0.803) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
11329 | STK38 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 249565889 |
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