Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/STIP1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/STIP1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/STIP1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/STIP1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/STIP1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/STIP1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/STIP1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/STIP1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0098760 | Colorectum | AD | response to interleukin-7 | 10/3918 | 15/18723 | 1.68e-04 | 2.29e-03 | 10 |
GO:0098761 | Colorectum | AD | cellular response to interleukin-7 | 10/3918 | 15/18723 | 1.68e-04 | 2.29e-03 | 10 |
GO:00987601 | Colorectum | SER | response to interleukin-7 | 8/2897 | 15/18723 | 7.51e-04 | 9.68e-03 | 8 |
GO:00987611 | Colorectum | SER | cellular response to interleukin-7 | 8/2897 | 15/18723 | 7.51e-04 | 9.68e-03 | 8 |
GO:00987602 | Colorectum | MSS | response to interleukin-7 | 10/3467 | 15/18723 | 5.64e-05 | 9.87e-04 | 10 |
GO:00987612 | Colorectum | MSS | cellular response to interleukin-7 | 10/3467 | 15/18723 | 5.64e-05 | 9.87e-04 | 10 |
GO:00987603 | Colorectum | MSI-H | response to interleukin-7 | 8/1319 | 15/18723 | 2.44e-06 | 1.43e-04 | 8 |
GO:00987613 | Colorectum | MSI-H | cellular response to interleukin-7 | 8/1319 | 15/18723 | 2.44e-06 | 1.43e-04 | 8 |
GO:009876019 | Esophagus | HGIN | response to interleukin-7 | 8/2587 | 15/18723 | 3.41e-04 | 5.55e-03 | 8 |
GO:009876119 | Esophagus | HGIN | cellular response to interleukin-7 | 8/2587 | 15/18723 | 3.41e-04 | 5.55e-03 | 8 |
GO:0098760110 | Esophagus | ESCC | response to interleukin-7 | 14/8552 | 15/18723 | 1.47e-04 | 9.85e-04 | 14 |
GO:0098761110 | Esophagus | ESCC | cellular response to interleukin-7 | 14/8552 | 15/18723 | 1.47e-04 | 9.85e-04 | 14 |
GO:00987607 | Liver | Cirrhotic | response to interleukin-7 | 10/4634 | 15/18723 | 7.26e-04 | 5.36e-03 | 10 |
GO:00987617 | Liver | Cirrhotic | cellular response to interleukin-7 | 10/4634 | 15/18723 | 7.26e-04 | 5.36e-03 | 10 |
GO:009876012 | Liver | HCC | response to interleukin-7 | 12/7958 | 15/18723 | 3.56e-03 | 1.59e-02 | 12 |
GO:009876112 | Liver | HCC | cellular response to interleukin-7 | 12/7958 | 15/18723 | 3.56e-03 | 1.59e-02 | 12 |
GO:009876017 | Oral cavity | OSCC | response to interleukin-7 | 14/7305 | 15/18723 | 1.79e-05 | 1.74e-04 | 14 |
GO:009876117 | Oral cavity | OSCC | cellular response to interleukin-7 | 14/7305 | 15/18723 | 1.79e-05 | 1.74e-04 | 14 |
GO:009876018 | Oral cavity | LP | response to interleukin-7 | 11/4623 | 15/18723 | 1.01e-04 | 1.24e-03 | 11 |
GO:009876118 | Oral cavity | LP | cellular response to interleukin-7 | 11/4623 | 15/18723 | 1.01e-04 | 1.24e-03 | 11 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STIP1 | SNV | Missense_Mutation | novel | c.114A>C | p.Glu38Asp | p.E38D | P31948 | protein_coding | tolerated_low_confidence(0.34) | benign(0) | TCGA-A2-A3XY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | PD |
STIP1 | SNV | Missense_Mutation | novel | c.1131C>G | p.His377Gln | p.H377Q | P31948 | protein_coding | deleterious(0) | possibly_damaging(0.877) | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD |
STIP1 | SNV | Missense_Mutation | | c.340N>G | p.Leu114Val | p.L114V | P31948 | protein_coding | deleterious(0.01) | benign(0.436) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR |
STIP1 | SNV | Missense_Mutation | novel | c.1133N>A | p.Arg378Gln | p.R378Q | P31948 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
STIP1 | SNV | Missense_Mutation | | c.1507G>C | p.Asp503His | p.D503H | P31948 | protein_coding | deleterious(0) | benign(0.393) | TCGA-EW-A1PB-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
STIP1 | insertion | Nonsense_Mutation | novel | c.413_414insTGCAAGACTGTCGACCTAAAGCCTGACTGGGGCAAGGT | p.Lys139AlafsTer6 | p.K139Afs*6 | P31948 | protein_coding | | | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
STIP1 | insertion | Frame_Shift_Ins | novel | c.1133_1134insCGGAG | p.Thr379GlyfsTer17 | p.T379Gfs*17 | P31948 | protein_coding | | | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD |
STIP1 | insertion | In_Frame_Ins | novel | c.1429_1430insTTTCACCAT | p.Gly477delinsValSerProCys | p.G477delinsVSPC | P31948 | protein_coding | | | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STIP1 | insertion | Frame_Shift_Ins | novel | c.1431_1432insTGGCCAGGCTGGTGTCAAACTCC | p.Tyr478TrpfsTer19 | p.Y478Wfs*19 | P31948 | protein_coding | | | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STIP1 | SNV | Missense_Mutation | novel | c.941N>T | p.Ala314Val | p.A314V | P31948 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |