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Gene: SKP1 |
Gene summary for SKP1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SKP1 | Gene ID | 6500 |
Gene name | S-phase kinase associated protein 1 | |
Gene Alias | EMC19 | |
Cytomap | 5q31.1 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | P63208 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6500 | SKP1 | P75T-E | Human | Esophagus | ESCC | 1.24e-89 | 2.70e+00 | 0.1125 |
6500 | SKP1 | P76T-E | Human | Esophagus | ESCC | 9.45e-70 | 1.96e+00 | 0.1207 |
6500 | SKP1 | P79T-E | Human | Esophagus | ESCC | 1.20e-72 | 1.89e+00 | 0.1154 |
6500 | SKP1 | P80T-E | Human | Esophagus | ESCC | 1.18e-79 | 3.42e+00 | 0.155 |
6500 | SKP1 | P82T-E | Human | Esophagus | ESCC | 2.76e-33 | 2.36e+00 | 0.1072 |
6500 | SKP1 | P83T-E | Human | Esophagus | ESCC | 2.46e-66 | 2.64e+00 | 0.1738 |
6500 | SKP1 | P84T-E | Human | Esophagus | ESCC | 1.49e-24 | 1.81e+00 | 0.0933 |
6500 | SKP1 | P89T-E | Human | Esophagus | ESCC | 1.25e-35 | 2.58e+00 | 0.1752 |
6500 | SKP1 | P91T-E | Human | Esophagus | ESCC | 1.80e-28 | 3.32e+00 | 0.1828 |
6500 | SKP1 | P94T-E | Human | Esophagus | ESCC | 3.75e-06 | 1.66e+00 | 0.0879 |
6500 | SKP1 | P107T-E | Human | Esophagus | ESCC | 4.19e-79 | 3.00e+00 | 0.171 |
6500 | SKP1 | P126T-E | Human | Esophagus | ESCC | 1.36e-29 | 2.63e+00 | 0.1125 |
6500 | SKP1 | P127T-E | Human | Esophagus | ESCC | 8.73e-80 | 2.06e+00 | 0.0826 |
6500 | SKP1 | P128T-E | Human | Esophagus | ESCC | 1.67e-59 | 2.31e+00 | 0.1241 |
6500 | SKP1 | P130T-E | Human | Esophagus | ESCC | 1.43e-89 | 3.25e+00 | 0.1676 |
6500 | SKP1 | NAFLD1 | Human | Liver | NAFLD | 1.07e-05 | -9.21e-01 | -0.04 |
6500 | SKP1 | S41 | Human | Liver | Cirrhotic | 4.90e-14 | -1.12e+00 | -0.0343 |
6500 | SKP1 | S42 | Human | Liver | HCC | 1.71e-07 | -1.07e+00 | -0.0103 |
6500 | SKP1 | S43 | Human | Liver | Cirrhotic | 4.75e-49 | -1.11e+00 | -0.0187 |
6500 | SKP1 | S44 | Human | Liver | HCC | 2.86e-05 | -9.00e-01 | -0.0083 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19033209 | Breast | Precancer | regulation of protein modification by small protein conjugation or removal | 38/1080 | 242/18723 | 1.71e-08 | 1.17e-06 | 38 |
GO:00313969 | Breast | Precancer | regulation of protein ubiquitination | 33/1080 | 210/18723 | 1.45e-07 | 7.82e-06 | 33 |
GO:00104989 | Breast | Precancer | proteasomal protein catabolic process | 58/1080 | 490/18723 | 1.54e-07 | 8.05e-06 | 58 |
GO:00451859 | Breast | Precancer | maintenance of protein location | 19/1080 | 94/18723 | 1.43e-06 | 5.35e-05 | 19 |
GO:00512358 | Breast | Precancer | maintenance of location | 40/1080 | 327/18723 | 5.85e-06 | 1.71e-04 | 40 |
GO:00516519 | Breast | Precancer | maintenance of location in cell | 30/1080 | 214/18723 | 5.91e-06 | 1.71e-04 | 30 |
GO:00325076 | Breast | Precancer | maintenance of protein location in cell | 14/1080 | 65/18723 | 1.59e-05 | 3.89e-04 | 14 |
GO:00725954 | Breast | Precancer | maintenance of protein localization in organelle | 10/1080 | 42/18723 | 1.06e-04 | 1.93e-03 | 10 |
GO:19046668 | Breast | Precancer | regulation of ubiquitin protein ligase activity | 7/1080 | 23/18723 | 2.26e-04 | 3.42e-03 | 7 |
GO:00431619 | Breast | Precancer | proteasome-mediated ubiquitin-dependent protein catabolic process | 42/1080 | 412/18723 | 2.49e-04 | 3.72e-03 | 42 |
GO:00514386 | Breast | Precancer | regulation of ubiquitin-protein transferase activity | 10/1080 | 53/18723 | 7.88e-04 | 9.29e-03 | 10 |
GO:001049814 | Breast | IDC | proteasomal protein catabolic process | 75/1434 | 490/18723 | 5.59e-09 | 4.41e-07 | 75 |
GO:190332014 | Breast | IDC | regulation of protein modification by small protein conjugation or removal | 43/1434 | 242/18723 | 1.71e-07 | 9.16e-06 | 43 |
GO:003139614 | Breast | IDC | regulation of protein ubiquitination | 37/1434 | 210/18723 | 1.50e-06 | 6.36e-05 | 37 |
GO:005165114 | Breast | IDC | maintenance of location in cell | 37/1434 | 214/18723 | 2.39e-06 | 9.35e-05 | 37 |
GO:004518514 | Breast | IDC | maintenance of protein location | 21/1434 | 94/18723 | 6.69e-06 | 2.05e-04 | 21 |
GO:004316114 | Breast | IDC | proteasome-mediated ubiquitin-dependent protein catabolic process | 57/1434 | 412/18723 | 9.55e-06 | 2.68e-04 | 57 |
GO:005123513 | Breast | IDC | maintenance of location | 48/1434 | 327/18723 | 9.90e-06 | 2.77e-04 | 48 |
GO:003250714 | Breast | IDC | maintenance of protein location in cell | 16/1434 | 65/18723 | 2.29e-05 | 5.51e-04 | 16 |
GO:007259512 | Breast | IDC | maintenance of protein localization in organelle | 12/1434 | 42/18723 | 4.94e-05 | 1.08e-03 | 12 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513218 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0513118 | Breast | Precancer | Shigellosis | 44/684 | 247/8465 | 3.91e-07 | 6.86e-06 | 5.26e-06 | 44 |
hsa0414118 | Breast | Precancer | Protein processing in endoplasmic reticulum | 33/684 | 174/8465 | 2.78e-06 | 3.83e-05 | 2.94e-05 | 33 |
hsa0513219 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0513119 | Breast | Precancer | Shigellosis | 44/684 | 247/8465 | 3.91e-07 | 6.86e-06 | 5.26e-06 | 44 |
hsa0414119 | Breast | Precancer | Protein processing in endoplasmic reticulum | 33/684 | 174/8465 | 2.78e-06 | 3.83e-05 | 2.94e-05 | 33 |
hsa0513224 | Breast | IDC | Salmonella infection | 55/867 | 249/8465 | 2.07e-08 | 4.49e-07 | 3.36e-07 | 55 |
hsa0513124 | Breast | IDC | Shigellosis | 47/867 | 247/8465 | 1.78e-05 | 2.00e-04 | 1.49e-04 | 47 |
hsa0414124 | Breast | IDC | Protein processing in endoplasmic reticulum | 36/867 | 174/8465 | 2.73e-05 | 2.86e-04 | 2.14e-04 | 36 |
hsa0517014 | Breast | IDC | Human immunodeficiency virus 1 infection | 33/867 | 212/8465 | 9.28e-03 | 4.37e-02 | 3.27e-02 | 33 |
hsa0513234 | Breast | IDC | Salmonella infection | 55/867 | 249/8465 | 2.07e-08 | 4.49e-07 | 3.36e-07 | 55 |
hsa0513134 | Breast | IDC | Shigellosis | 47/867 | 247/8465 | 1.78e-05 | 2.00e-04 | 1.49e-04 | 47 |
hsa0414134 | Breast | IDC | Protein processing in endoplasmic reticulum | 36/867 | 174/8465 | 2.73e-05 | 2.86e-04 | 2.14e-04 | 36 |
hsa0517015 | Breast | IDC | Human immunodeficiency virus 1 infection | 33/867 | 212/8465 | 9.28e-03 | 4.37e-02 | 3.27e-02 | 33 |
hsa0513243 | Breast | DCIS | Salmonella infection | 55/846 | 249/8465 | 8.71e-09 | 1.87e-07 | 1.38e-07 | 55 |
hsa0414143 | Breast | DCIS | Protein processing in endoplasmic reticulum | 36/846 | 174/8465 | 1.60e-05 | 1.91e-04 | 1.41e-04 | 36 |
hsa0513144 | Breast | DCIS | Shigellosis | 46/846 | 247/8465 | 2.06e-05 | 2.38e-04 | 1.75e-04 | 46 |
hsa0517024 | Breast | DCIS | Human immunodeficiency virus 1 infection | 33/846 | 212/8465 | 6.49e-03 | 3.22e-02 | 2.37e-02 | 33 |
hsa0513253 | Breast | DCIS | Salmonella infection | 55/846 | 249/8465 | 8.71e-09 | 1.87e-07 | 1.38e-07 | 55 |
hsa0414153 | Breast | DCIS | Protein processing in endoplasmic reticulum | 36/846 | 174/8465 | 1.60e-05 | 1.91e-04 | 1.41e-04 | 36 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SKP1 | SNV | Missense_Mutation | novel | c.228G>C | p.Glu76Asp | p.E76D | P63208 | protein_coding | tolerated(0.54) | benign(0.005) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SKP1 | SNV | Missense_Mutation | novel | c.411N>T | p.Lys137Asn | p.K137N | P63208 | protein_coding | deleterious(0.04) | benign(0.158) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SKP1 | SNV | Missense_Mutation | novel | c.407G>C | p.Arg136Pro | p.R136P | P63208 | protein_coding | deleterious(0.01) | benign(0.012) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SKP1 | SNV | Missense_Mutation | novel | c.406N>T | p.Arg136Cys | p.R136C | P63208 | protein_coding | deleterious(0.04) | benign(0.011) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
SKP1 | SNV | Missense_Mutation | novel | c.382N>C | p.Lys128Gln | p.K128Q | P63208 | protein_coding | deleterious(0) | possibly_damaging(0.656) | TCGA-D1-A1O8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SKP1 | insertion | Frame_Shift_Ins | novel | c.226_227insCATCTTTATTATCTTTGCGTATAGCAATTCGTATTATTGGGCAAGAC | p.Glu76AlafsTer34 | p.E76Afs*34 | P63208 | protein_coding | TCGA-DD-A73E-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
SKP1 | SNV | Missense_Mutation | c.49N>T | p.Asp17Tyr | p.D17Y | P63208 | protein_coding | deleterious(0) | possibly_damaging(0.891) | TCGA-05-4382-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SKP1 | SNV | Missense_Mutation | novel | c.239A>G | p.Lys80Arg | p.K80R | P63208 | protein_coding | tolerated(0.27) | possibly_damaging(0.899) | TCGA-05-4427-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
SKP1 | SNV | Missense_Mutation | novel | c.139N>G | p.Leu47Val | p.L47V | P63208 | protein_coding | tolerated(0.11) | probably_damaging(0.959) | TCGA-49-6742-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | alimta | PD |
SKP1 | SNV | Missense_Mutation | novel | c.317N>G | p.Ala106Gly | p.A106G | P63208 | protein_coding | deleterious(0) | possibly_damaging(0.698) | TCGA-55-8089-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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