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Gene: SHFM1 |
Gene summary for SHFM1 |
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Gene information | Species | Human | Gene symbol | SHFM1 | Gene ID | 7979 |
Gene name | SEM1 26S proteasome subunit | |
Gene Alias | C7orf76 | |
Cytomap | 7q21.3 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | P60896 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7979 | SHFM1 | P83T-E | Human | Esophagus | ESCC | 3.37e-77 | 3.67e+00 | 0.1738 |
7979 | SHFM1 | P84T-E | Human | Esophagus | ESCC | 1.50e-20 | 1.96e+00 | 0.0933 |
7979 | SHFM1 | P89T-E | Human | Esophagus | ESCC | 2.06e-47 | 3.90e+00 | 0.1752 |
7979 | SHFM1 | P91T-E | Human | Esophagus | ESCC | 1.21e-33 | 3.44e+00 | 0.1828 |
7979 | SHFM1 | P94T-E | Human | Esophagus | ESCC | 1.38e-10 | 2.00e+00 | 0.0879 |
7979 | SHFM1 | P107T-E | Human | Esophagus | ESCC | 9.78e-84 | 3.62e+00 | 0.171 |
7979 | SHFM1 | P126T-E | Human | Esophagus | ESCC | 5.07e-20 | 2.89e+00 | 0.1125 |
7979 | SHFM1 | P127T-E | Human | Esophagus | ESCC | 2.51e-73 | 1.88e+00 | 0.0826 |
7979 | SHFM1 | P128T-E | Human | Esophagus | ESCC | 3.72e-71 | 3.39e+00 | 0.1241 |
7979 | SHFM1 | P130T-E | Human | Esophagus | ESCC | 7.98e-101 | 3.40e+00 | 0.1676 |
7979 | SHFM1 | S41 | Human | Liver | Cirrhotic | 1.15e-08 | -8.96e-01 | -0.0343 |
7979 | SHFM1 | S42 | Human | Liver | HCC | 7.68e-05 | -8.96e-01 | -0.0103 |
7979 | SHFM1 | S43 | Human | Liver | Cirrhotic | 5.07e-40 | -8.96e-01 | -0.0187 |
7979 | SHFM1 | S44 | Human | Liver | HCC | 8.77e-04 | -8.96e-01 | -0.0083 |
7979 | SHFM1 | HCC1_Meng | Human | Liver | HCC | 2.67e-41 | 3.72e-01 | 0.0246 |
7979 | SHFM1 | HCC2_Meng | Human | Liver | HCC | 1.08e-43 | 8.65e-02 | 0.0107 |
7979 | SHFM1 | cirrhotic1 | Human | Liver | Cirrhotic | 4.85e-37 | 2.68e-01 | 0.0202 |
7979 | SHFM1 | cirrhotic2 | Human | Liver | Cirrhotic | 1.24e-27 | 1.31e-01 | 0.0201 |
7979 | SHFM1 | cirrhotic3 | Human | Liver | Cirrhotic | 1.41e-33 | 2.58e-01 | 0.0215 |
7979 | SHFM1 | p6 | Human | Liver | Cyst | 1.15e-08 | -8.96e-01 | -0.0218 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502016 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501416 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0305010 | Breast | Precancer | Proteasome | 25/684 | 46/8465 | 4.35e-16 | 9.81e-15 | 7.52e-15 | 25 |
hsa0501714 | Breast | Precancer | Spinocerebellar ataxia | 29/684 | 143/8465 | 2.79e-06 | 3.83e-05 | 2.94e-05 | 29 |
hsa0516918 | Breast | Precancer | Epstein-Barr virus infection | 35/684 | 202/8465 | 1.15e-05 | 1.26e-04 | 9.64e-05 | 35 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502017 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501417 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0305013 | Breast | Precancer | Proteasome | 25/684 | 46/8465 | 4.35e-16 | 9.81e-15 | 7.52e-15 | 25 |
hsa0501715 | Breast | Precancer | Spinocerebellar ataxia | 29/684 | 143/8465 | 2.79e-06 | 3.83e-05 | 2.94e-05 | 29 |
hsa0516919 | Breast | Precancer | Epstein-Barr virus infection | 35/684 | 202/8465 | 1.15e-05 | 1.26e-04 | 9.64e-05 | 35 |
hsa0501224 | Breast | IDC | Parkinson disease | 107/867 | 266/8465 | 2.57e-39 | 8.36e-37 | 6.26e-37 | 107 |
hsa0502023 | Breast | IDC | Prion disease | 102/867 | 273/8465 | 3.70e-34 | 4.01e-32 | 3.00e-32 | 102 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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