Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SELENOK

Gene summary for SELENOK

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SELENOK

Gene ID

58515

Gene nameselenoprotein K
Gene AliasHSPC030
Cytomap3p21.1
Gene Typeprotein-coding
GO ID

GO:0001775

UniProtAcc

Q9Y6D0


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
58515SELENOKGSM5353220_PA_PB1B_Pool_3_S51_L002HumanProstateTumor8.55e-11-1.10e+000.1531
58515SELENOKGSM5353221_PA_PB2A_Pool_1_3_S25_L001HumanProstateTumor1.62e-34-1.10e+000.1633
58515SELENOKGSM5353222_PA_PB2B_Pool_1_3_S52_L002HumanProstateTumor9.36e-47-1.10e+000.1608
58515SELENOKGSM5353223_PA_PB2B_Pool_2_S26_L001HumanProstateTumor9.06e-30-1.10e+000.1604
58515SELENOKGSM5353224_PA_PR5186_Pool_1_2_3_S27_L001HumanProstateTumor8.88e-32-1.10e+000.1621
58515SELENOKGSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002HumanProstateTumor4.66e-18-1.10e+000.1619
58515SELENOKGSM5353226_PA_PR5196-2_Pool_1_2_3_S54_L002HumanProstateTumor2.68e-12-1.10e+000.159
58515SELENOKGSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002HumanProstateTumor4.80e-36-1.10e+000.1602
58515SELENOKGSM5353228_PA_PR5199-640K_Pool_1_3_S108_L004HumanProstateTumor3.57e-07-1.10e+000.1537
58515SELENOKGSM5353232_PA_PR5249_T1_S3_L001HumanProstateTumor2.75e-10-1.10e+000.1439
58515SELENOKGSM5353236_PA_PR5251_T1_S7_L001HumanProstateTumor1.94e-19-1.10e+000.1608
58515SELENOKGSM5353237_PA_PR5251_T2_S8_L001HumanProstateTumor2.68e-12-1.10e+000.1622
58515SELENOKGSM5353240_PA_PR5254_T1_S15_L001HumanProstateTumor6.07e-53-1.10e+000.1575
58515SELENOKGSM5353243_PA_PR5261_T1_S23_L002HumanProstateTumor1.49e-57-1.10e+000.1545
58515SELENOKGSM5353244_PA_PR5261_T2_S24_L002HumanProstateTumor9.72e-46-1.10e+000.1569
58515SELENOKGSM5353247_PA_PR5269_3_S27_L002HumanProstateTumor4.15e-06-1.10e+000.1532
58515SELENOKGSM5353248_PA_PR5269_4_S28_L002HumanProstateTumor8.91e-10-1.10e+000.1541
58515SELENOKPat01-BHumanStomachGC1.54e-467.76e-010.5754
58515SELENOKPat02-BHumanStomachGC2.04e-679.27e-010.0368
58515SELENOKPat03-BHumanStomachGC5.06e-407.01e-010.3693
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
BreastThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.IDC: Invasive ductal carcinoma
DCIS: Ductal carcinoma in situ
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00971939BreastPrecancerintrinsic apoptotic signaling pathway59/1080288/187238.07e-183.60e-1559
GO:00069799BreastPrecancerresponse to oxidative stress70/1080446/187231.59e-144.26e-1270
GO:00349769BreastPrecancerresponse to endoplasmic reticulum stress38/1080256/187237.89e-084.60e-0638
GO:00509006BreastPrecancerleukocyte migration47/1080369/187232.82e-071.39e-0547
GO:00457859BreastPrecancerpositive regulation of cell adhesion52/1080437/187235.74e-072.49e-0552
GO:00018196BreastPrecancerpositive regulation of cytokine production52/1080467/187234.18e-061.29e-0452
GO:00421107BreastPrecancerT cell activation52/1080487/187231.37e-053.42e-0452
GO:00508707BreastPrecancerpositive regulation of T cell activation29/1080216/187231.94e-054.58e-0429
GO:19030396BreastPrecancerpositive regulation of leukocyte cell-cell adhesion30/1080239/187235.13e-051.07e-0330
GO:00026856BreastPrecancerregulation of leukocyte migration27/1080210/187237.93e-051.54e-0327
GO:00508637BreastPrecancerregulation of T cell activation37/1080329/187238.04e-051.56e-0337
GO:00224098BreastPrecancerpositive regulation of cell-cell adhesion33/1080284/187231.03e-041.89e-0333
GO:00071597BreastPrecancerleukocyte cell-cell adhesion40/1080371/187231.07e-041.94e-0340
GO:00457305BreastPrecancerrespiratory burst9/108037/187231.96e-043.10e-039
GO:00224079BreastPrecancerregulation of cell-cell adhesion45/1080448/187232.12e-043.30e-0345
GO:00700598BreastPrecancerintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress12/108063/187232.21e-043.37e-0312
GO:19030377BreastPrecancerregulation of leukocyte cell-cell adhesion36/1080336/187232.61e-043.84e-0336
GO:00716744BreastPrecancermononuclear cell migration24/1080196/187234.03e-045.44e-0324
GO:00026877BreastPrecancerpositive regulation of leukocyte migration18/1080135/187237.60e-049.04e-0318
GO:00716774BreastPrecancerpositive regulation of mononuclear cell migration11/108065/187231.13e-031.25e-0211
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SELENOKSNVMissense_Mutationc.14N>Gp.Ser5Trpp.S5Wprotein_codingdeleterious(0)possibly_damaging(0.829)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
SELENOKSNVMissense_Mutationc.149N>Ap.Arg50Lysp.R50Kprotein_codingtolerated(0.48)benign(0.026)TCGA-EK-A2RJ-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
SELENOKSNVMissense_Mutationc.245N>Ap.Gly82Aspp.G82Dprotein_codingdeleterious(0.01)probably_damaging(0.999)TCGA-WS-AB45-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
SELENOKdeletionFrame_Shift_Delnovelc.145delAp.Arg49GlufsTer51p.R49Efs*51protein_codingTCGA-5M-AAT6-01Colorectumcolon adenocarcinomaFemale<65III/IVUnknownUnknownPD
SELENOKSNVMissense_Mutationc.81N>Ap.Phe27Leup.F27Lprotein_codingdeleterious(0.02)probably_damaging(0.973)TCGA-AP-A059-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
SELENOKSNVMissense_Mutationrs376660375c.241N>Tp.Arg81Cysp.R81Cprotein_codingdeleterious(0.04)benign(0.192)TCGA-BG-A220-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
SELENOKdeletionFrame_Shift_Delnovelc.145delNp.Arg49GlufsTer51p.R49Efs*51protein_codingTCGA-AX-A1CE-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnspecificPaclitaxelSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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