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Gene: PPDPF |
Gene summary for PPDPF |
Gene summary. |
Gene information | Species | Human | Gene symbol | PPDPF | Gene ID | 79144 |
Gene name | pancreatic progenitor cell differentiation and proliferation factor | |
Gene Alias | C20orf149 | |
Cytomap | 20q13.33 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9H3Y8 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79144 | PPDPF | P42T-E | Human | Esophagus | ESCC | 1.39e-48 | 2.13e+00 | 0.1175 |
79144 | PPDPF | P44T-E | Human | Esophagus | ESCC | 1.81e-52 | 2.53e+00 | 0.1096 |
79144 | PPDPF | P47T-E | Human | Esophagus | ESCC | 1.90e-90 | 3.18e+00 | 0.1067 |
79144 | PPDPF | P48T-E | Human | Esophagus | ESCC | 3.86e-73 | 2.15e+00 | 0.0959 |
79144 | PPDPF | P49T-E | Human | Esophagus | ESCC | 6.72e-36 | 4.76e+00 | 0.1768 |
79144 | PPDPF | P52T-E | Human | Esophagus | ESCC | 5.10e-98 | 3.17e+00 | 0.1555 |
79144 | PPDPF | P54T-E | Human | Esophagus | ESCC | 3.91e-67 | 3.11e+00 | 0.0975 |
79144 | PPDPF | P56T-E | Human | Esophagus | ESCC | 1.47e-20 | 4.17e+00 | 0.1613 |
79144 | PPDPF | P57T-E | Human | Esophagus | ESCC | 7.03e-87 | 3.42e+00 | 0.0926 |
79144 | PPDPF | P61T-E | Human | Esophagus | ESCC | 1.50e-55 | 2.38e+00 | 0.099 |
79144 | PPDPF | P62T-E | Human | Esophagus | ESCC | 5.73e-85 | 3.25e+00 | 0.1302 |
79144 | PPDPF | P65T-E | Human | Esophagus | ESCC | 6.23e-79 | 3.18e+00 | 0.0978 |
79144 | PPDPF | P74T-E | Human | Esophagus | ESCC | 1.04e-76 | 3.94e+00 | 0.1479 |
79144 | PPDPF | P75T-E | Human | Esophagus | ESCC | 5.79e-99 | 4.34e+00 | 0.1125 |
79144 | PPDPF | P76T-E | Human | Esophagus | ESCC | 3.04e-110 | 3.85e+00 | 0.1207 |
79144 | PPDPF | P79T-E | Human | Esophagus | ESCC | 1.84e-100 | 4.21e+00 | 0.1154 |
79144 | PPDPF | P80T-E | Human | Esophagus | ESCC | 1.04e-63 | 3.07e+00 | 0.155 |
79144 | PPDPF | P82T-E | Human | Esophagus | ESCC | 5.60e-35 | 4.72e+00 | 0.1072 |
79144 | PPDPF | P83T-E | Human | Esophagus | ESCC | 5.53e-93 | 4.68e+00 | 0.1738 |
79144 | PPDPF | P84T-E | Human | Esophagus | ESCC | 2.01e-20 | 3.20e+00 | 0.0933 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPDPF | SNV | Missense_Mutation | c.131N>T | p.Pro44Leu | p.P44L | Q9H3Y8 | protein_coding | deleterious(0.02) | possibly_damaging(0.456) | TCGA-E9-A22E-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphane | SD | |
PPDPF | SNV | Missense_Mutation | novel | c.174N>A | p.Phe58Leu | p.F58L | Q9H3Y8 | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
PPDPF | SNV | Missense_Mutation | novel | c.80N>G | p.Asn27Ser | p.N27S | Q9H3Y8 | protein_coding | tolerated(0.3) | benign(0.028) | TCGA-DD-AAE3-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PPDPF | SNV | Missense_Mutation | c.257N>A | p.Ser86Asn | p.S86N | Q9H3Y8 | protein_coding | tolerated(0.18) | benign(0.003) | TCGA-MI-A75H-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PPDPF | SNV | Missense_Mutation | c.164N>T | p.Trp55Leu | p.W55L | Q9H3Y8 | protein_coding | deleterious(0) | possibly_damaging(0.856) | TCGA-64-5815-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | gemcitabine | CR | |
PPDPF | SNV | Missense_Mutation | rs759954043 | c.233N>G | p.Ser78Trp | p.S78W | Q9H3Y8 | protein_coding | deleterious(0.02) | possibly_damaging(0.753) | TCGA-NJ-A4YP-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PPDPF | SNV | Missense_Mutation | c.136N>G | p.Leu46Val | p.L46V | Q9H3Y8 | protein_coding | tolerated(0.07) | benign(0.292) | TCGA-18-3406-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PPDPF | SNV | Missense_Mutation | novel | c.197N>T | p.Pro66Leu | p.P66L | Q9H3Y8 | protein_coding | tolerated(0.08) | probably_damaging(1) | TCGA-CR-5248-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | PD |
PPDPF | SNV | Missense_Mutation | novel | c.211N>A | p.Val71Met | p.V71M | Q9H3Y8 | protein_coding | deleterious(0.03) | possibly_damaging(0.543) | TCGA-MT-A67F-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PPDPF | SNV | Missense_Mutation | novel | c.250N>C | p.Ser84Pro | p.S84P | Q9H3Y8 | protein_coding | tolerated(0.18) | benign(0.022) | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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