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Gene: PON2 |
Gene summary for PON2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | PON2 | Gene ID | 5445 |
Gene name | paraoxonase 2 | |
Gene Alias | PON2 | |
Cytomap | 7q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006725 | UniProtAcc | A0A0J9YYG4 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5445 | PON2 | Pat25-A | Human | Stomach | CAG with IM | 1.10e-11 | 8.46e-02 | -0.1648 |
5445 | PON2 | Pat26-A | Human | Stomach | CSG | 1.49e-05 | 7.20e-02 | -0.2402 |
5445 | PON2 | Pat28-A | Human | Stomach | CSG | 6.85e-03 | 1.72e-01 | -0.2594 |
5445 | PON2 | male-WTA | Human | Thyroid | PTC | 2.19e-52 | 5.03e-01 | 0.1037 |
5445 | PON2 | PTC01 | Human | Thyroid | PTC | 2.65e-33 | 7.69e-01 | 0.1899 |
5445 | PON2 | PTC04 | Human | Thyroid | PTC | 4.00e-27 | 7.26e-01 | 0.1927 |
5445 | PON2 | PTC05 | Human | Thyroid | PTC | 1.60e-26 | 1.26e+00 | 0.2065 |
5445 | PON2 | PTC06 | Human | Thyroid | PTC | 2.56e-75 | 1.94e+00 | 0.2057 |
5445 | PON2 | PTC07 | Human | Thyroid | PTC | 1.23e-67 | 1.39e+00 | 0.2044 |
5445 | PON2 | ATC08 | Human | Thyroid | ATC | 5.98e-08 | 1.65e-01 | 0.0541 |
5445 | PON2 | ATC09 | Human | Thyroid | ATC | 5.96e-11 | 6.94e-01 | 0.2871 |
5445 | PON2 | ATC11 | Human | Thyroid | ATC | 6.83e-09 | 6.13e-01 | 0.3386 |
5445 | PON2 | ATC12 | Human | Thyroid | ATC | 1.42e-09 | 2.46e-01 | 0.34 |
5445 | PON2 | ATC13 | Human | Thyroid | ATC | 2.61e-91 | 1.83e+00 | 0.34 |
5445 | PON2 | ATC1 | Human | Thyroid | ATC | 1.10e-12 | 7.83e-01 | 0.2878 |
5445 | PON2 | ATC2 | Human | Thyroid | ATC | 9.90e-23 | 1.68e+00 | 0.34 |
5445 | PON2 | ATC3 | Human | Thyroid | ATC | 3.38e-12 | 4.74e-01 | 0.338 |
5445 | PON2 | ATC4 | Human | Thyroid | ATC | 2.09e-12 | 3.17e-01 | 0.34 |
5445 | PON2 | ATC5 | Human | Thyroid | ATC | 2.25e-87 | 1.93e+00 | 0.34 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000223710 | Endometrium | AEH | response to molecule of bacterial origin | 65/2100 | 363/18723 | 9.00e-05 | 1.30e-03 | 65 |
GO:003249610 | Endometrium | AEH | response to lipopolysaccharide | 62/2100 | 343/18723 | 9.82e-05 | 1.41e-03 | 62 |
GO:00096159 | Endometrium | AEH | response to virus | 63/2100 | 367/18723 | 3.81e-04 | 4.10e-03 | 63 |
GO:00712229 | Endometrium | AEH | cellular response to lipopolysaccharide | 37/2100 | 209/18723 | 3.30e-03 | 2.31e-02 | 37 |
GO:00712169 | Endometrium | AEH | cellular response to biotic stimulus | 42/2100 | 246/18723 | 3.65e-03 | 2.50e-02 | 42 |
GO:00018198 | Endometrium | AEH | positive regulation of cytokine production | 71/2100 | 467/18723 | 4.76e-03 | 3.02e-02 | 71 |
GO:00712199 | Endometrium | AEH | cellular response to molecule of bacterial origin | 37/2100 | 221/18723 | 8.34e-03 | 4.56e-02 | 37 |
GO:000223714 | Endometrium | EEC | response to molecule of bacterial origin | 68/2168 | 363/18723 | 3.96e-05 | 6.64e-04 | 68 |
GO:003249614 | Endometrium | EEC | response to lipopolysaccharide | 65/2168 | 343/18723 | 4.04e-05 | 6.75e-04 | 65 |
GO:000961513 | Endometrium | EEC | response to virus | 66/2168 | 367/18723 | 1.78e-04 | 2.20e-03 | 66 |
GO:007122213 | Endometrium | EEC | cellular response to lipopolysaccharide | 40/2168 | 209/18723 | 9.31e-04 | 8.37e-03 | 40 |
GO:007121613 | Endometrium | EEC | cellular response to biotic stimulus | 45/2168 | 246/18723 | 1.24e-03 | 1.03e-02 | 45 |
GO:007121913 | Endometrium | EEC | cellular response to molecule of bacterial origin | 40/2168 | 221/18723 | 2.73e-03 | 1.97e-02 | 40 |
GO:000181913 | Endometrium | EEC | positive regulation of cytokine production | 73/2168 | 467/18723 | 4.64e-03 | 2.97e-02 | 73 |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:001943918 | Esophagus | ESCC | aromatic compound catabolic process | 295/8552 | 467/18723 | 1.09e-14 | 5.98e-13 | 295 |
GO:000961518 | Esophagus | ESCC | response to virus | 238/8552 | 367/18723 | 6.65e-14 | 3.32e-12 | 238 |
GO:00516075 | Esophagus | ESCC | defense response to virus | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:01405465 | Esophagus | ESCC | defense response to symbiont | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:000963620 | Esophagus | ESCC | response to toxic substance | 150/8552 | 262/18723 | 1.00e-04 | 7.12e-04 | 150 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PON2 | SNV | Missense_Mutation | c.396C>A | p.Asn132Lys | p.N132K | Q15165 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AO-A03O-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD | |
PON2 | insertion | Nonsense_Mutation | novel | c.102_103insTATTGTATTCTCACATCCTATTGACCCAAACTTAGACATAT | p.Glu35TyrfsTer8 | p.E35Yfs*8 | Q15165 | protein_coding | TCGA-A7-A0CG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PON2 | SNV | Missense_Mutation | c.333N>G | p.Phe111Leu | p.F111L | Q15165 | protein_coding | deleterious(0.04) | benign(0.118) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
PON2 | SNV | Missense_Mutation | c.139G>A | p.Gly47Arg | p.G47R | Q15165 | protein_coding | deleterious(0.01) | possibly_damaging(0.879) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PON2 | SNV | Missense_Mutation | c.619N>C | p.Tyr207His | p.Y207H | Q15165 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PON2 | SNV | Missense_Mutation | c.261G>T | p.Met87Ile | p.M87I | Q15165 | protein_coding | tolerated(0.08) | benign(0.003) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
PON2 | SNV | Missense_Mutation | novel | c.743N>G | p.Glu248Gly | p.E248G | Q15165 | protein_coding | deleterious(0) | possibly_damaging(0.572) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PON2 | SNV | Missense_Mutation | c.860N>A | p.Gly287Asp | p.G287D | Q15165 | protein_coding | deleterious(0.03) | possibly_damaging(0.865) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PON2 | SNV | Missense_Mutation | c.442G>A | p.Ala148Thr | p.A148T | Q15165 | protein_coding | deleterious(0.03) | benign(0.039) | TCGA-AG-A014-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PON2 | deletion | Frame_Shift_Del | c.195delT | p.Phe65LeufsTer5 | p.F65Lfs*5 | Q15165 | protein_coding | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5445 | PON2 | DRUGGABLE GENOME, ENZYME | antidepressants |
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