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Gene: PEBP1 |
Gene summary for PEBP1 |
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Gene information | Species | Human | Gene symbol | PEBP1 | Gene ID | 5037 |
Gene name | phosphatidylethanolamine binding protein 1 | |
Gene Alias | HCNP | |
Cytomap | 12q24.23 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | D9IAI1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5037 | PEBP1 | P39T-E | Human | Esophagus | ESCC | 1.37e-04 | 4.37e-01 | 0.0894 |
5037 | PEBP1 | P40T-E | Human | Esophagus | ESCC | 9.50e-22 | 1.34e+00 | 0.109 |
5037 | PEBP1 | P42T-E | Human | Esophagus | ESCC | 3.30e-11 | 1.07e+00 | 0.1175 |
5037 | PEBP1 | P44T-E | Human | Esophagus | ESCC | 1.79e-12 | 1.02e+00 | 0.1096 |
5037 | PEBP1 | P47T-E | Human | Esophagus | ESCC | 2.03e-24 | 1.11e+00 | 0.1067 |
5037 | PEBP1 | P48T-E | Human | Esophagus | ESCC | 1.14e-28 | 1.18e+00 | 0.0959 |
5037 | PEBP1 | P49T-E | Human | Esophagus | ESCC | 3.70e-16 | 2.27e+00 | 0.1768 |
5037 | PEBP1 | P52T-E | Human | Esophagus | ESCC | 1.10e-38 | 1.83e+00 | 0.1555 |
5037 | PEBP1 | P54T-E | Human | Esophagus | ESCC | 2.59e-25 | 1.50e+00 | 0.0975 |
5037 | PEBP1 | P56T-E | Human | Esophagus | ESCC | 7.62e-16 | 2.92e+00 | 0.1613 |
5037 | PEBP1 | P57T-E | Human | Esophagus | ESCC | 7.89e-48 | 1.55e+00 | 0.0926 |
5037 | PEBP1 | P61T-E | Human | Esophagus | ESCC | 9.85e-11 | 9.68e-01 | 0.099 |
5037 | PEBP1 | P62T-E | Human | Esophagus | ESCC | 3.47e-70 | 2.10e+00 | 0.1302 |
5037 | PEBP1 | P65T-E | Human | Esophagus | ESCC | 3.74e-28 | 1.21e+00 | 0.0978 |
5037 | PEBP1 | P74T-E | Human | Esophagus | ESCC | 9.79e-45 | 1.82e+00 | 0.1479 |
5037 | PEBP1 | P75T-E | Human | Esophagus | ESCC | 1.24e-57 | 1.85e+00 | 0.1125 |
5037 | PEBP1 | P76T-E | Human | Esophagus | ESCC | 4.32e-47 | 1.79e+00 | 0.1207 |
5037 | PEBP1 | P79T-E | Human | Esophagus | ESCC | 8.07e-70 | 2.15e+00 | 0.1154 |
5037 | PEBP1 | P80T-E | Human | Esophagus | ESCC | 1.07e-73 | 3.03e+00 | 0.155 |
5037 | PEBP1 | P82T-E | Human | Esophagus | ESCC | 6.34e-15 | 1.74e+00 | 0.1072 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00525479 | Breast | Precancer | regulation of peptidase activity | 71/1080 | 461/18723 | 2.72e-14 | 6.94e-12 | 71 |
GO:00525489 | Breast | Precancer | regulation of endopeptidase activity | 67/1080 | 432/18723 | 1.06e-13 | 2.36e-11 | 67 |
GO:00458619 | Breast | Precancer | negative regulation of proteolysis | 50/1080 | 351/18723 | 2.99e-09 | 2.39e-07 | 50 |
GO:00513468 | Breast | Precancer | negative regulation of hydrolase activity | 50/1080 | 379/18723 | 3.85e-08 | 2.34e-06 | 50 |
GO:00104668 | Breast | Precancer | negative regulation of peptidase activity | 38/1080 | 262/18723 | 1.46e-07 | 7.82e-06 | 38 |
GO:00109519 | Breast | Precancer | negative regulation of endopeptidase activity | 37/1080 | 252/18723 | 1.55e-07 | 8.05e-06 | 37 |
GO:005254714 | Breast | IDC | regulation of peptidase activity | 96/1434 | 461/18723 | 7.58e-20 | 6.15e-17 | 96 |
GO:005254814 | Breast | IDC | regulation of endopeptidase activity | 88/1434 | 432/18723 | 1.20e-17 | 4.85e-15 | 88 |
GO:004586114 | Breast | IDC | negative regulation of proteolysis | 70/1434 | 351/18723 | 8.21e-14 | 2.22e-11 | 70 |
GO:005134613 | Breast | IDC | negative regulation of hydrolase activity | 71/1434 | 379/18723 | 1.33e-12 | 2.90e-10 | 71 |
GO:001046613 | Breast | IDC | negative regulation of peptidase activity | 56/1434 | 262/18723 | 1.39e-12 | 2.92e-10 | 56 |
GO:001095112 | Breast | IDC | negative regulation of endopeptidase activity | 52/1434 | 252/18723 | 3.53e-11 | 5.57e-09 | 52 |
GO:005254723 | Breast | DCIS | regulation of peptidase activity | 88/1390 | 461/18723 | 1.18e-16 | 4.78e-14 | 88 |
GO:005254823 | Breast | DCIS | regulation of endopeptidase activity | 83/1390 | 432/18723 | 6.07e-16 | 2.15e-13 | 83 |
GO:004586123 | Breast | DCIS | negative regulation of proteolysis | 63/1390 | 351/18723 | 4.39e-11 | 6.06e-09 | 63 |
GO:005134623 | Breast | DCIS | negative regulation of hydrolase activity | 64/1390 | 379/18723 | 4.32e-10 | 4.80e-08 | 64 |
GO:001046622 | Breast | DCIS | negative regulation of peptidase activity | 49/1390 | 262/18723 | 1.54e-09 | 1.43e-07 | 49 |
GO:001095122 | Breast | DCIS | negative regulation of endopeptidase activity | 47/1390 | 252/18723 | 3.63e-09 | 3.11e-07 | 47 |
GO:005254710 | Cervix | CC | regulation of peptidase activity | 112/2311 | 461/18723 | 6.70e-13 | 3.08e-10 | 112 |
GO:005254810 | Cervix | CC | regulation of endopeptidase activity | 103/2311 | 432/18723 | 1.89e-11 | 5.14e-09 | 103 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PEBP1 | SNV | Missense_Mutation | c.440N>T | p.Gly147Val | p.G147V | P30086 | protein_coding | tolerated(0.18) | benign(0.141) | TCGA-D8-A147-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
PEBP1 | SNV | Missense_Mutation | rs530714085 | c.422N>A | p.Arg141Gln | p.R141Q | P30086 | protein_coding | tolerated(0.13) | benign(0.029) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PEBP1 | SNV | Missense_Mutation | novel | c.275N>C | p.Met92Thr | p.M92T | P30086 | protein_coding | deleterious(0) | benign(0.171) | TCGA-AP-A1DO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PEBP1 | SNV | Missense_Mutation | rs530714085 | c.422G>A | p.Arg141Gln | p.R141Q | P30086 | protein_coding | tolerated(0.13) | benign(0.029) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
PEBP1 | SNV | Missense_Mutation | c.161C>T | p.Ser54Leu | p.S54L | P30086 | protein_coding | tolerated(0.2) | benign(0.013) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
PEBP1 | SNV | Missense_Mutation | rs777648257 | c.347G>A | p.Gly116Asp | p.G116D | P30086 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
PEBP1 | SNV | Missense_Mutation | novel | c.541N>C | p.Tyr181His | p.Y181H | P30086 | protein_coding | tolerated(0.19) | benign(0.001) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
PEBP1 | SNV | Missense_Mutation | novel | c.325T>A | p.Ser109Thr | p.S109T | P30086 | protein_coding | deleterious(0) | benign(0.282) | TCGA-DD-AAD6-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
PEBP1 | SNV | Missense_Mutation | c.328N>T | p.Gly110Trp | p.G110W | P30086 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-05-4244-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PEBP1 | SNV | Missense_Mutation | c.172N>G | p.Leu58Val | p.L58V | P30086 | protein_coding | tolerated(0.36) | benign(0.006) | TCGA-97-7938-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5037 | PEBP1 | KINASE, PROTEASE INHIBITOR | FLUTAMIDE | FLUTAMIDE | 12377983 | |
5037 | PEBP1 | KINASE, PROTEASE INHIBITOR | DHT | ANDROSTANOLONE | 12417618 |
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