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Gene: PDLIM5 |
Gene summary for PDLIM5 |
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Gene information | Species | Human | Gene symbol | PDLIM5 | Gene ID | 10611 |
Gene name | PDZ and LIM domain 5 | |
Gene Alias | ENH | |
Cytomap | 4q22.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q96HC4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10611 | PDLIM5 | P75T-E | Human | Esophagus | ESCC | 4.68e-64 | 1.54e+00 | 0.1125 |
10611 | PDLIM5 | P76T-E | Human | Esophagus | ESCC | 3.64e-29 | 8.22e-01 | 0.1207 |
10611 | PDLIM5 | P79T-E | Human | Esophagus | ESCC | 2.85e-08 | 2.81e-01 | 0.1154 |
10611 | PDLIM5 | P80T-E | Human | Esophagus | ESCC | 1.56e-48 | 1.82e+00 | 0.155 |
10611 | PDLIM5 | P82T-E | Human | Esophagus | ESCC | 6.24e-34 | 2.13e+00 | 0.1072 |
10611 | PDLIM5 | P83T-E | Human | Esophagus | ESCC | 1.14e-22 | 6.20e-01 | 0.1738 |
10611 | PDLIM5 | P84T-E | Human | Esophagus | ESCC | 3.98e-12 | 1.49e+00 | 0.0933 |
10611 | PDLIM5 | P89T-E | Human | Esophagus | ESCC | 2.69e-15 | 1.19e+00 | 0.1752 |
10611 | PDLIM5 | P91T-E | Human | Esophagus | ESCC | 5.89e-13 | 1.81e+00 | 0.1828 |
10611 | PDLIM5 | P104T-E | Human | Esophagus | ESCC | 1.63e-06 | 6.55e-01 | 0.0931 |
10611 | PDLIM5 | P107T-E | Human | Esophagus | ESCC | 9.22e-47 | 1.32e+00 | 0.171 |
10611 | PDLIM5 | P126T-E | Human | Esophagus | ESCC | 1.19e-07 | 1.70e+00 | 0.1125 |
10611 | PDLIM5 | P127T-E | Human | Esophagus | ESCC | 3.46e-45 | 1.18e+00 | 0.0826 |
10611 | PDLIM5 | P128T-E | Human | Esophagus | ESCC | 4.36e-50 | 2.06e+00 | 0.1241 |
10611 | PDLIM5 | P130T-E | Human | Esophagus | ESCC | 6.46e-61 | 1.33e+00 | 0.1676 |
10611 | PDLIM5 | NAFLD1 | Human | Liver | NAFLD | 1.22e-12 | 1.09e+00 | -0.04 |
10611 | PDLIM5 | S41 | Human | Liver | Cirrhotic | 4.01e-02 | 5.26e-01 | -0.0343 |
10611 | PDLIM5 | HCC1_Meng | Human | Liver | HCC | 7.83e-107 | -1.82e-01 | 0.0246 |
10611 | PDLIM5 | HCC2_Meng | Human | Liver | HCC | 6.19e-46 | -2.53e-02 | 0.0107 |
10611 | PDLIM5 | cirrhotic1 | Human | Liver | Cirrhotic | 1.55e-09 | -3.03e-01 | 0.0202 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00160497 | Breast | Precancer | cell growth | 46/1080 | 482/18723 | 5.63e-04 | 7.16e-03 | 46 |
GO:00605374 | Breast | Precancer | muscle tissue development | 37/1080 | 403/18723 | 3.60e-03 | 2.98e-02 | 37 |
GO:00147063 | Breast | Precancer | striated muscle tissue development | 35/1080 | 384/18723 | 5.10e-03 | 3.83e-02 | 35 |
GO:006053711 | Breast | IDC | muscle tissue development | 50/1434 | 403/18723 | 4.91e-04 | 6.45e-03 | 50 |
GO:001604913 | Breast | IDC | cell growth | 56/1434 | 482/18723 | 1.16e-03 | 1.26e-02 | 56 |
GO:00147061 | Breast | IDC | striated muscle tissue development | 46/1434 | 384/18723 | 1.67e-03 | 1.63e-02 | 46 |
GO:00426923 | Breast | IDC | muscle cell differentiation | 44/1434 | 384/18723 | 4.77e-03 | 3.66e-02 | 44 |
GO:00030125 | Breast | IDC | muscle system process | 50/1434 | 452/18723 | 5.52e-03 | 4.05e-02 | 50 |
GO:00511463 | Breast | IDC | striated muscle cell differentiation | 34/1434 | 283/18723 | 6.00e-03 | 4.31e-02 | 34 |
GO:006053721 | Breast | DCIS | muscle tissue development | 50/1390 | 403/18723 | 2.39e-04 | 3.74e-03 | 50 |
GO:00147062 | Breast | DCIS | striated muscle tissue development | 46/1390 | 384/18723 | 8.88e-04 | 1.01e-02 | 46 |
GO:001604923 | Breast | DCIS | cell growth | 54/1390 | 482/18723 | 1.60e-03 | 1.59e-02 | 54 |
GO:000301212 | Breast | DCIS | muscle system process | 50/1390 | 452/18723 | 3.02e-03 | 2.57e-02 | 50 |
GO:004269211 | Breast | DCIS | muscle cell differentiation | 43/1390 | 384/18723 | 4.56e-03 | 3.49e-02 | 43 |
GO:005114611 | Breast | DCIS | striated muscle cell differentiation | 33/1390 | 283/18723 | 6.63e-03 | 4.62e-02 | 33 |
GO:00343298 | Cervix | CC | cell junction assembly | 88/2311 | 420/18723 | 3.42e-07 | 1.38e-05 | 88 |
GO:00163587 | Cervix | CC | dendrite development | 58/2311 | 243/18723 | 4.52e-07 | 1.76e-05 | 58 |
GO:00109757 | Cervix | CC | regulation of neuron projection development | 88/2311 | 445/18723 | 4.26e-06 | 1.09e-04 | 88 |
GO:00160498 | Cervix | CC | cell growth | 92/2311 | 482/18723 | 1.16e-05 | 2.49e-04 | 92 |
GO:00609965 | Cervix | CC | dendritic spine development | 28/2311 | 99/18723 | 1.61e-05 | 3.15e-04 | 28 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDLIM5 | SNV | Missense_Mutation | c.160G>C | p.Asp54His | p.D54H | Q96HC4 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
PDLIM5 | SNV | Missense_Mutation | c.151N>G | p.Leu51Val | p.L51V | Q96HC4 | protein_coding | tolerated(0.57) | benign(0.017) | TCGA-C5-A1BK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
PDLIM5 | SNV | Missense_Mutation | novel | c.1148C>T | p.Ser383Phe | p.S383F | Q96HC4 | protein_coding | deleterious(0.01) | benign(0.311) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PDLIM5 | SNV | Missense_Mutation | novel | c.82N>A | p.Leu28Met | p.L28M | Q96HC4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VS-A9U7-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PDLIM5 | SNV | Missense_Mutation | novel | c.1387G>A | p.Ala463Thr | p.A463T | Q96HC4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
PDLIM5 | SNV | Missense_Mutation | rs201891054 | c.427N>T | p.Arg143Cys | p.R143C | Q96HC4 | protein_coding | deleterious(0.03) | possibly_damaging(0.764) | TCGA-A6-6654-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
PDLIM5 | SNV | Missense_Mutation | novel | c.218N>A | p.Cys73Tyr | p.C73Y | Q96HC4 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD |
PDLIM5 | SNV | Missense_Mutation | novel | c.1076N>C | p.Leu359Pro | p.L359P | Q96HC4 | protein_coding | tolerated(0.29) | benign(0.001) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PDLIM5 | SNV | Missense_Mutation | novel | c.1334N>A | p.Arg445Gln | p.R445Q | Q96HC4 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PDLIM5 | SNV | Missense_Mutation | c.1090N>G | p.Ser364Ala | p.S364A | Q96HC4 | protein_coding | tolerated(0.16) | benign(0.003) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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