Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/MRPS18C_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/MRPS18C_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/MRPS18C_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/MRPS18C_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/MRPS18C_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRPS18C | SNV | Missense_Mutation | | c.340G>A | p.Ala114Thr | p.A114T | Q9Y3D5 | protein_coding | deleterious(0.01) | benign(0.248) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MRPS18C | SNV | Missense_Mutation | | c.254N>G | p.Ser85Cys | p.S85C | Q9Y3D5 | protein_coding | deleterious(0.01) | probably_damaging(0.983) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MRPS18C | SNV | Missense_Mutation | | c.355N>G | p.Phe119Val | p.F119V | Q9Y3D5 | protein_coding | deleterious(0) | possibly_damaging(0.57) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MRPS18C | SNV | Missense_Mutation | novel | c.182N>A | p.Pro61His | p.P61H | Q9Y3D5 | protein_coding | deleterious(0) | possibly_damaging(0.498) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRPS18C | SNV | Missense_Mutation | novel | c.318N>C | p.Glu106Asp | p.E106D | Q9Y3D5 | protein_coding | tolerated(0.08) | probably_damaging(0.953) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRPS18C | SNV | Missense_Mutation | rs375755956 | c.422N>A | p.Arg141Gln | p.R141Q | Q9Y3D5 | protein_coding | tolerated_low_confidence(0.32) | benign(0) | TCGA-D1-A17B-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MRPS18C | SNV | Missense_Mutation | rs753785951 | c.400A>G | p.Lys134Glu | p.K134E | Q9Y3D5 | protein_coding | deleterious(0) | benign(0.197) | TCGA-DD-AAD8-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MRPS18C | SNV | Missense_Mutation | novel | c.64N>A | p.Ala22Thr | p.A22T | Q9Y3D5 | protein_coding | tolerated(0.15) | benign(0.142) | TCGA-55-7815-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | chemo | PD |
MRPS18C | insertion | Nonsense_Mutation | novel | c.94_95insTCGCTTTATAGGGGAGAGAGCAAAAGGGAG | p.His32delinsLeuAlaLeuTerGlyArgGluGlnLysGlyAsp | p.H32delinsLAL*GREQKGD | Q9Y3D5 | protein_coding | | | TCGA-CN-4723-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MRPS18C | SNV | Missense_Mutation | rs773020951 | c.193T>C | p.Cys65Arg | p.C65R | Q9Y3D5 | protein_coding | deleterious(0) | possibly_damaging(0.83) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |