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Gene: LINC00493 |
Gene summary for LINC00493 |
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Gene information | Species | Human | Gene symbol | LINC00493 | Gene ID | 388789 |
Gene name | small integral membrane protein 26 | |
Gene Alias | LINC00493 | |
Cytomap | 20p11.23 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
388789 | LINC00493 | P5_S10_cSCC | Human | Skin | cSCC | 4.45e-10 | -2.73e-01 | -0.299 |
388789 | LINC00493 | P1_cSCC | Human | Skin | cSCC | 1.32e-52 | 1.62e+00 | 0.0292 |
388789 | LINC00493 | P2_cSCC | Human | Skin | cSCC | 2.31e-50 | 1.09e+00 | -0.024 |
388789 | LINC00493 | P4_cSCC | Human | Skin | cSCC | 1.14e-58 | 1.13e+00 | -0.00290000000000005 |
388789 | LINC00493 | P10_cSCC | Human | Skin | cSCC | 1.78e-45 | 1.31e+00 | 0.1017 |
388789 | LINC00493 | cSCC_p1 | Human | Skin | cSCC | 5.28e-10 | 4.35e-01 | -0.1916 |
388789 | LINC00493 | cSCC_p10 | Human | Skin | cSCC | 3.60e-05 | 3.41e-01 | -0.2095 |
388789 | LINC00493 | cSCC_p11 | Human | Skin | cSCC | 1.45e-05 | 4.12e-01 | -0.2102 |
388789 | LINC00493 | cSCC_p4 | Human | Skin | cSCC | 1.11e-17 | 4.83e-01 | -0.2022 |
388789 | LINC00493 | cSCC_p6 | Human | Skin | cSCC | 3.04e-17 | 4.64e-01 | -0.1989 |
388789 | LINC00493 | cSCC_p7 | Human | Skin | cSCC | 8.02e-05 | 2.78e-01 | -0.2332 |
388789 | LINC00493 | cSCC_p8 | Human | Skin | cSCC | 8.72e-23 | 4.53e-01 | -0.1971 |
388789 | LINC00493 | cSCC_p9 | Human | Skin | cSCC | 1.96e-22 | 4.69e-01 | -0.1991 |
388789 | LINC00493 | Adj_PTCwithHT_6 | Human | Thyroid | HT | 6.30e-06 | -4.94e-01 | 0.02 |
388789 | LINC00493 | PTCwithoutHT_2 | Human | Thyroid | PTC | 6.67e-04 | -4.63e-01 | 0.0419 |
388789 | LINC00493 | PTCwithoutHT_7 | Human | Thyroid | PTC | 9.83e-04 | -6.16e-01 | 0.0381 |
388789 | LINC00493 | male-WTA | Human | Thyroid | PTC | 8.48e-15 | -6.16e-01 | 0.1037 |
388789 | LINC00493 | female-WTA | Human | Thyroid | PTC | 4.68e-05 | -6.16e-01 | 0.0726 |
388789 | LINC00493 | nodule-WTA | Human | Thyroid | goiters | 1.56e-12 | -6.16e-01 | 0.0534 |
388789 | LINC00493 | PTC01 | Human | Thyroid | PTC | 9.50e-14 | -6.16e-01 | 0.1899 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LINC00493 | SNV | Missense_Mutation | novel | c.7N>G | p.Arg3Gly | p.R3G | protein_coding | tolerated(0.35) | benign(0.012) | TCGA-A2-A3XT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | PR | |
LINC00493 | SNV | Missense_Mutation | novel | c.20C>T | p.Thr7Met | p.T7M | protein_coding | tolerated(0.21) | possibly_damaging(0.54) | TCGA-LL-A73Z-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
LINC00493 | SNV | Missense_Mutation | novel | c.237N>T | p.Lys79Asn | p.K79N | protein_coding | deleterious(0.01) | possibly_damaging(0.857) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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