Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: KIAA1109

Gene summary for KIAA1109

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

KIAA1109

Gene ID

84162

Gene nameKIAA1109
Gene AliasALKKUCS
Cytomap4q27
Gene Typeprotein-coding
GO ID

GO:0001558

UniProtAcc

Q2LD37


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
84162KIAA1109047563_1562-all-cellsHumanProstateBPH1.74e-032.17e-010.0791
84162KIAA1109048752_1579-all-cellsHumanProstateBPH1.48e-143.65e-010.1008
84162KIAA1109052095_1628-all-cellsHumanProstateBPH8.46e-113.69e-010.1032
84162KIAA1109052097_1595-all-cellsHumanProstateBPH6.07e-093.46e-010.0972
84162KIAA1109052099_1652-all-cellsHumanProstateBPH7.67e-083.18e-010.1038
84162KIAA1109Dong_P1HumanProstateTumor1.06e-073.55e-020.035
84162KIAA1109Dong_P3HumanProstateTumor4.15e-081.43e-010.0278
84162KIAA1109Dong_P5HumanProstateTumor6.35e-03-5.83e-020.053
84162KIAA1109GSM5353215_PA_AUG_PB_1B_S2HumanProstateTumor1.03e-069.07e-010.1557
84162KIAA1109GSM5353216_PA_PB1A_Pool_1_3_S50_L002HumanProstateTumor4.40e-091.00e+000.159
84162KIAA1109GSM5353217_PA_PB1A_Pool_2_S107_L004HumanProstateTumor2.54e-037.99e-010.156
84162KIAA1109GSM5353221_PA_PB2A_Pool_1_3_S25_L001HumanProstateTumor1.50e-229.40e-010.1633
84162KIAA1109GSM5353222_PA_PB2B_Pool_1_3_S52_L002HumanProstateTumor4.50e-238.92e-010.1608
84162KIAA1109GSM5353223_PA_PB2B_Pool_2_S26_L001HumanProstateTumor5.26e-158.43e-010.1604
84162KIAA1109GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001HumanProstateTumor5.14e-157.49e-010.1621
84162KIAA1109GSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002HumanProstateTumor7.59e-035.82e-010.1619
84162KIAA1109GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002HumanProstateTumor3.41e-127.35e-010.1602
84162KIAA1109GSM5353236_PA_PR5251_T1_S7_L001HumanProstateTumor1.14e-025.67e-010.1608
84162KIAA1109GSM5353240_PA_PR5254_T1_S15_L001HumanProstateTumor5.25e-064.68e-010.1575
84162KIAA1109GSM5353243_PA_PR5261_T1_S23_L002HumanProstateTumor2.89e-064.82e-010.1545
Page: 1 2 3 4 5 6 7 8 9 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0016197ColorectumADendosomal transport90/3918230/187231.88e-101.73e-0890
GO:0098876ColorectumADvesicle-mediated transport to the plasma membrane57/3918136/187232.30e-081.27e-0657
GO:0016049ColorectumADcell growth143/3918482/187232.83e-068.09e-05143
GO:0001558ColorectumADregulation of cell growth124/3918414/187237.67e-061.86e-04124
GO:0032456ColorectumADendocytic recycling28/391873/187234.87e-045.30e-0328
GO:0099003ColorectumADvesicle-mediated transport in synapse57/3918200/187236.53e-034.06e-0257
GO:00161971ColorectumSERendosomal transport61/2897230/187231.03e-053.35e-0461
GO:00988761ColorectumSERvesicle-mediated transport to the plasma membrane37/2897136/187233.08e-045.00e-0337
GO:00015581ColorectumSERregulation of cell growth90/2897414/187234.00e-046.02e-0390
GO:00160491ColorectumSERcell growth100/2897482/187231.07e-031.24e-02100
GO:00988762ColorectumMSSvesicle-mediated transport to the plasma membrane54/3467136/187236.20e-093.95e-0754
GO:00161972ColorectumMSSendosomal transport79/3467230/187237.04e-094.39e-0779
GO:00160492ColorectumMSScell growth123/3467482/187237.15e-051.21e-03123
GO:00015582ColorectumMSSregulation of cell growth105/3467414/187232.97e-043.90e-03105
GO:00324561ColorectumMSSendocytic recycling26/346773/187234.05e-044.99e-0326
GO:00990031ColorectumMSSvesicle-mediated transport in synapse54/3467200/187231.94e-031.67e-0254
GO:0099504ColorectumMSSsynaptic vesicle cycle48/3467181/187234.85e-033.39e-0248
GO:0048488ColorectumMSSsynaptic vesicle endocytosis20/346762/187236.63e-034.38e-0220
GO:0140238ColorectumMSSpresynaptic endocytosis20/346762/187236.63e-034.38e-0220
GO:0036465ColorectumMSSsynaptic vesicle recycling23/346775/187237.49e-034.72e-0223
Page: 1 2 3 4 5 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
KIAA1109SNVMissense_Mutationnovelc.5587N>Ap.Glu1863Lysp.E1863KQ2LD37protein_codingtolerated(0.19)benign(0.01)TCGA-5L-AAT1-01Breastbreast invasive carcinomaFemale<65III/IVHormone TherapyletrozolSD
KIAA1109SNVMissense_Mutationnovelc.9077G>Cp.Arg3026Thrp.R3026TQ2LD37protein_codingtolerated(0.95)benign(0.021)TCGA-A2-A0CR-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinCR
KIAA1109SNVMissense_Mutationc.6074N>Ap.Arg2025Lysp.R2025KQ2LD37protein_codingtolerated(0.22)probably_damaging(0.931)TCGA-A2-A0YG-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycytoxanSD
KIAA1109SNVMissense_Mutationc.7274A>Cp.Glu2425Alap.E2425AQ2LD37protein_codingtolerated(0.05)possibly_damaging(0.6)TCGA-A2-A25B-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxoterePD
KIAA1109SNVMissense_Mutationc.11197N>Ap.Glu3733Lysp.E3733KQ2LD37protein_codingtolerated(0.13)benign(0.052)TCGA-A8-A081-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
KIAA1109SNVMissense_Mutationc.10295C>Tp.Thr3432Ilep.T3432IQ2LD37protein_codingtolerated(0.49)probably_damaging(0.987)TCGA-A8-A08L-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownSD
KIAA1109SNVMissense_Mutationc.320N>Ap.Arg107Glnp.R107QQ2LD37protein_codingdeleterious(0)probably_damaging(0.968)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
KIAA1109SNVMissense_Mutationc.5959N>Gp.Leu1987Valp.L1987VQ2LD37protein_codingtolerated(0.29)benign(0.001)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
KIAA1109SNVMissense_Mutationc.7249N>Ap.Gln2417Lysp.Q2417KQ2LD37protein_codingtolerated(0.26)possibly_damaging(0.542)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
KIAA1109SNVMissense_Mutationnovelc.7532N>Tp.Pro2511Leup.P2511LQ2LD37protein_codingdeleterious(0)probably_damaging(0.997)TCGA-AC-A5EH-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1