Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84162 | KIAA1109 | 047563_1562-all-cells | Human | Prostate | BPH | 1.74e-03 | 2.17e-01 | 0.0791 |
84162 | KIAA1109 | 048752_1579-all-cells | Human | Prostate | BPH | 1.48e-14 | 3.65e-01 | 0.1008 |
84162 | KIAA1109 | 052095_1628-all-cells | Human | Prostate | BPH | 8.46e-11 | 3.69e-01 | 0.1032 |
84162 | KIAA1109 | 052097_1595-all-cells | Human | Prostate | BPH | 6.07e-09 | 3.46e-01 | 0.0972 |
84162 | KIAA1109 | 052099_1652-all-cells | Human | Prostate | BPH | 7.67e-08 | 3.18e-01 | 0.1038 |
84162 | KIAA1109 | Dong_P1 | Human | Prostate | Tumor | 1.06e-07 | 3.55e-02 | 0.035 |
84162 | KIAA1109 | Dong_P3 | Human | Prostate | Tumor | 4.15e-08 | 1.43e-01 | 0.0278 |
84162 | KIAA1109 | Dong_P5 | Human | Prostate | Tumor | 6.35e-03 | -5.83e-02 | 0.053 |
84162 | KIAA1109 | GSM5353215_PA_AUG_PB_1B_S2 | Human | Prostate | Tumor | 1.03e-06 | 9.07e-01 | 0.1557 |
84162 | KIAA1109 | GSM5353216_PA_PB1A_Pool_1_3_S50_L002 | Human | Prostate | Tumor | 4.40e-09 | 1.00e+00 | 0.159 |
84162 | KIAA1109 | GSM5353217_PA_PB1A_Pool_2_S107_L004 | Human | Prostate | Tumor | 2.54e-03 | 7.99e-01 | 0.156 |
84162 | KIAA1109 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 1.50e-22 | 9.40e-01 | 0.1633 |
84162 | KIAA1109 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 4.50e-23 | 8.92e-01 | 0.1608 |
84162 | KIAA1109 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 5.26e-15 | 8.43e-01 | 0.1604 |
84162 | KIAA1109 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 5.14e-15 | 7.49e-01 | 0.1621 |
84162 | KIAA1109 | GSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002 | Human | Prostate | Tumor | 7.59e-03 | 5.82e-01 | 0.1619 |
84162 | KIAA1109 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 3.41e-12 | 7.35e-01 | 0.1602 |
84162 | KIAA1109 | GSM5353236_PA_PR5251_T1_S7_L001 | Human | Prostate | Tumor | 1.14e-02 | 5.67e-01 | 0.1608 |
84162 | KIAA1109 | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 5.25e-06 | 4.68e-01 | 0.1575 |
84162 | KIAA1109 | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 2.89e-06 | 4.82e-01 | 0.1545 |
Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/KIAA1109_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/KIAA1109_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/KIAA1109_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/KIAA1109_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/KIAA1109_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/KIAA1109_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/KIAA1109_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016197 | Colorectum | AD | endosomal transport | 90/3918 | 230/18723 | 1.88e-10 | 1.73e-08 | 90 |
GO:0098876 | Colorectum | AD | vesicle-mediated transport to the plasma membrane | 57/3918 | 136/18723 | 2.30e-08 | 1.27e-06 | 57 |
GO:0016049 | Colorectum | AD | cell growth | 143/3918 | 482/18723 | 2.83e-06 | 8.09e-05 | 143 |
GO:0001558 | Colorectum | AD | regulation of cell growth | 124/3918 | 414/18723 | 7.67e-06 | 1.86e-04 | 124 |
GO:0032456 | Colorectum | AD | endocytic recycling | 28/3918 | 73/18723 | 4.87e-04 | 5.30e-03 | 28 |
GO:0099003 | Colorectum | AD | vesicle-mediated transport in synapse | 57/3918 | 200/18723 | 6.53e-03 | 4.06e-02 | 57 |
GO:00161971 | Colorectum | SER | endosomal transport | 61/2897 | 230/18723 | 1.03e-05 | 3.35e-04 | 61 |
GO:00988761 | Colorectum | SER | vesicle-mediated transport to the plasma membrane | 37/2897 | 136/18723 | 3.08e-04 | 5.00e-03 | 37 |
GO:00015581 | Colorectum | SER | regulation of cell growth | 90/2897 | 414/18723 | 4.00e-04 | 6.02e-03 | 90 |
GO:00160491 | Colorectum | SER | cell growth | 100/2897 | 482/18723 | 1.07e-03 | 1.24e-02 | 100 |
GO:00988762 | Colorectum | MSS | vesicle-mediated transport to the plasma membrane | 54/3467 | 136/18723 | 6.20e-09 | 3.95e-07 | 54 |
GO:00161972 | Colorectum | MSS | endosomal transport | 79/3467 | 230/18723 | 7.04e-09 | 4.39e-07 | 79 |
GO:00160492 | Colorectum | MSS | cell growth | 123/3467 | 482/18723 | 7.15e-05 | 1.21e-03 | 123 |
GO:00015582 | Colorectum | MSS | regulation of cell growth | 105/3467 | 414/18723 | 2.97e-04 | 3.90e-03 | 105 |
GO:00324561 | Colorectum | MSS | endocytic recycling | 26/3467 | 73/18723 | 4.05e-04 | 4.99e-03 | 26 |
GO:00990031 | Colorectum | MSS | vesicle-mediated transport in synapse | 54/3467 | 200/18723 | 1.94e-03 | 1.67e-02 | 54 |
GO:0099504 | Colorectum | MSS | synaptic vesicle cycle | 48/3467 | 181/18723 | 4.85e-03 | 3.39e-02 | 48 |
GO:0048488 | Colorectum | MSS | synaptic vesicle endocytosis | 20/3467 | 62/18723 | 6.63e-03 | 4.38e-02 | 20 |
GO:0140238 | Colorectum | MSS | presynaptic endocytosis | 20/3467 | 62/18723 | 6.63e-03 | 4.38e-02 | 20 |
GO:0036465 | Colorectum | MSS | synaptic vesicle recycling | 23/3467 | 75/18723 | 7.49e-03 | 4.72e-02 | 23 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA1109 | SNV | Missense_Mutation | novel | c.5587N>A | p.Glu1863Lys | p.E1863K | Q2LD37 | protein_coding | tolerated(0.19) | benign(0.01) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
KIAA1109 | SNV | Missense_Mutation | novel | c.9077G>C | p.Arg3026Thr | p.R3026T | Q2LD37 | protein_coding | tolerated(0.95) | benign(0.021) | TCGA-A2-A0CR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
KIAA1109 | SNV | Missense_Mutation | | c.6074N>A | p.Arg2025Lys | p.R2025K | Q2LD37 | protein_coding | tolerated(0.22) | probably_damaging(0.931) | TCGA-A2-A0YG-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
KIAA1109 | SNV | Missense_Mutation | | c.7274A>C | p.Glu2425Ala | p.E2425A | Q2LD37 | protein_coding | tolerated(0.05) | possibly_damaging(0.6) | TCGA-A2-A25B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | PD |
KIAA1109 | SNV | Missense_Mutation | | c.11197N>A | p.Glu3733Lys | p.E3733K | Q2LD37 | protein_coding | tolerated(0.13) | benign(0.052) | TCGA-A8-A081-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIAA1109 | SNV | Missense_Mutation | | c.10295C>T | p.Thr3432Ile | p.T3432I | Q2LD37 | protein_coding | tolerated(0.49) | probably_damaging(0.987) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
KIAA1109 | SNV | Missense_Mutation | | c.320N>A | p.Arg107Gln | p.R107Q | Q2LD37 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
KIAA1109 | SNV | Missense_Mutation | | c.5959N>G | p.Leu1987Val | p.L1987V | Q2LD37 | protein_coding | tolerated(0.29) | benign(0.001) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
KIAA1109 | SNV | Missense_Mutation | | c.7249N>A | p.Gln2417Lys | p.Q2417K | Q2LD37 | protein_coding | tolerated(0.26) | possibly_damaging(0.542) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
KIAA1109 | SNV | Missense_Mutation | novel | c.7532N>T | p.Pro2511Leu | p.P2511L | Q2LD37 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AC-A5EH-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |