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Gene: HMGB2 |
Gene summary for HMGB2 |
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Gene information | Species | Human | Gene symbol | HMGB2 | Gene ID | 3148 |
Gene name | high mobility group box 2 | |
Gene Alias | HMG2 | |
Cytomap | 4q34.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P26583 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3148 | HMGB2 | P4_cSCC | Human | Skin | cSCC | 3.46e-22 | 1.78e+00 | -0.00290000000000005 |
3148 | HMGB2 | P10_cSCC | Human | Skin | cSCC | 1.55e-16 | 1.72e+00 | 0.1017 |
3148 | HMGB2 | cSCC_p4 | Human | Skin | cSCC | 7.75e-04 | 1.60e-01 | -0.2022 |
3148 | HMGB2 | Adj_PTCwithHT_6 | Human | Thyroid | HT | 5.43e-05 | -3.46e-01 | 0.02 |
3148 | HMGB2 | PTCwithHT_8 | Human | Thyroid | HT | 6.04e-04 | -4.20e-01 | 0.0351 |
3148 | HMGB2 | PTCwithoutHT_2 | Human | Thyroid | PTC | 9.32e-05 | -3.54e-01 | 0.0419 |
3148 | HMGB2 | male-WTA | Human | Thyroid | PTC | 1.53e-42 | -6.79e-02 | 0.1037 |
3148 | HMGB2 | PTC01 | Human | Thyroid | PTC | 1.63e-15 | 1.48e-01 | 0.1899 |
3148 | HMGB2 | PTC04 | Human | Thyroid | PTC | 3.30e-09 | 4.14e-02 | 0.1927 |
3148 | HMGB2 | PTC05 | Human | Thyroid | PTC | 1.59e-11 | 1.01e+00 | 0.2065 |
3148 | HMGB2 | PTC06 | Human | Thyroid | PTC | 1.11e-16 | 7.07e-01 | 0.2057 |
3148 | HMGB2 | PTC07 | Human | Thyroid | PTC | 5.45e-27 | 5.79e-01 | 0.2044 |
3148 | HMGB2 | ATC08 | Human | Thyroid | ATC | 1.31e-04 | -1.25e-01 | 0.0541 |
3148 | HMGB2 | ATC09 | Human | Thyroid | ATC | 2.70e-05 | -2.36e-01 | 0.2871 |
3148 | HMGB2 | ATC1 | Human | Thyroid | ATC | 1.86e-04 | -1.82e-01 | 0.2878 |
3148 | HMGB2 | ATC2 | Human | Thyroid | ATC | 5.15e-09 | 1.94e+00 | 0.34 |
3148 | HMGB2 | ATC4 | Human | Thyroid | ATC | 8.69e-03 | 6.79e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:20012339 | Breast | Precancer | regulation of apoptotic signaling pathway | 65/1080 | 356/18723 | 7.70e-17 | 3.17e-14 | 65 |
GO:00485459 | Breast | Precancer | response to steroid hormone | 53/1080 | 339/18723 | 3.07e-11 | 3.66e-09 | 53 |
GO:20012349 | Breast | Precancer | negative regulation of apoptotic signaling pathway | 39/1080 | 224/18723 | 5.35e-10 | 4.77e-08 | 39 |
GO:00022629 | Breast | Precancer | myeloid cell homeostasis | 27/1080 | 157/18723 | 3.10e-07 | 1.49e-05 | 27 |
GO:00603266 | Breast | Precancer | cell chemotaxis | 41/1080 | 310/18723 | 5.99e-07 | 2.55e-05 | 41 |
GO:00511019 | Breast | Precancer | regulation of DNA binding | 22/1080 | 118/18723 | 9.28e-07 | 3.71e-05 | 22 |
GO:00341019 | Breast | Precancer | erythrocyte homeostasis | 23/1080 | 129/18723 | 1.20e-06 | 4.60e-05 | 23 |
GO:00433887 | Breast | Precancer | positive regulation of DNA binding | 14/1080 | 56/18723 | 2.46e-06 | 8.35e-05 | 14 |
GO:00510989 | Breast | Precancer | regulation of binding | 44/1080 | 363/18723 | 2.59e-06 | 8.65e-05 | 44 |
GO:00300999 | Breast | Precancer | myeloid cell differentiation | 45/1080 | 381/18723 | 4.00e-06 | 1.25e-04 | 45 |
GO:00018196 | Breast | Precancer | positive regulation of cytokine production | 52/1080 | 467/18723 | 4.18e-06 | 1.29e-04 | 52 |
GO:20012369 | Breast | Precancer | regulation of extrinsic apoptotic signaling pathway | 24/1080 | 151/18723 | 5.78e-06 | 1.70e-04 | 24 |
GO:00022378 | Breast | Precancer | response to molecule of bacterial origin | 43/1080 | 363/18723 | 6.05e-06 | 1.72e-04 | 43 |
GO:00324968 | Breast | Precancer | response to lipopolysaccharide | 41/1080 | 343/18723 | 7.94e-06 | 2.17e-04 | 41 |
GO:00971919 | Breast | Precancer | extrinsic apoptotic signaling pathway | 30/1080 | 219/18723 | 9.42e-06 | 2.50e-04 | 30 |
GO:00456379 | Breast | Precancer | regulation of myeloid cell differentiation | 28/1080 | 210/18723 | 3.05e-05 | 6.72e-04 | 28 |
GO:00321034 | Breast | Precancer | positive regulation of response to external stimulus | 46/1080 | 427/18723 | 3.41e-05 | 7.40e-04 | 46 |
GO:19037069 | Breast | Precancer | regulation of hemopoiesis | 41/1080 | 367/18723 | 3.95e-05 | 8.52e-04 | 41 |
GO:00506736 | Breast | Precancer | epithelial cell proliferation | 46/1080 | 437/18723 | 6.02e-05 | 1.23e-03 | 46 |
GO:00313493 | Breast | Precancer | positive regulation of defense response | 33/1080 | 278/18723 | 6.79e-05 | 1.36e-03 | 33 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HMGB2 | SNV | Missense_Mutation | c.97N>A | p.Asp33Asn | p.D33N | P26583 | protein_coding | tolerated(0.2) | benign(0.319) | TCGA-A1-A0SF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | tc | SD | |
HMGB2 | SNV | Missense_Mutation | c.346N>A | p.Glu116Lys | p.E116K | P26583 | protein_coding | tolerated(0.07) | benign(0.199) | TCGA-C8-A274-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
HMGB2 | SNV | Missense_Mutation | c.36A>T | p.Lys12Asn | p.K12N | P26583 | protein_coding | tolerated(0.08) | probably_damaging(0.998) | TCGA-E2-A15O-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | PD | |
HMGB2 | insertion | Frame_Shift_Ins | novel | c.214_215insCTCA | p.Asp72AlafsTer14 | p.D72Afs*14 | P26583 | protein_coding | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | SD | |||
HMGB2 | insertion | Nonsense_Mutation | novel | c.213_214insCCCAGCACTTTGGGAGTGTGAGGTGGGAG | p.Asp72ProfsTer7 | p.D72Pfs*7 | P26583 | protein_coding | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | SD | |||
HMGB2 | SNV | Missense_Mutation | c.346N>A | p.Glu116Lys | p.E116K | P26583 | protein_coding | tolerated(0.07) | benign(0.199) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
HMGB2 | SNV | Missense_Mutation | novel | c.263N>C | p.Lys88Thr | p.K88T | P26583 | protein_coding | deleterious(0.01) | benign(0.241) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HMGB2 | SNV | Missense_Mutation | c.251N>T | p.Asp84Val | p.D84V | P26583 | protein_coding | deleterious(0.05) | benign(0) | TCGA-CM-6676-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HMGB2 | SNV | Missense_Mutation | c.627A>T | p.Glu209Asp | p.E209D | P26583 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.935) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
HMGB2 | insertion | Nonsense_Mutation | novel | c.422_423insCTG | p.Lys141delinsAsnTer | p.K141delinsN* | P26583 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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