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Gene: HDHD3 |
Gene summary for HDHD3 |
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Gene information | Species | Human | Gene symbol | HDHD3 | Gene ID | 81932 |
Gene name | haloacid dehalogenase like hydrolase domain containing 3 | |
Gene Alias | 2810435D12Rik | |
Cytomap | 9q32 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9BSH5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81932 | HDHD3 | Pat06-B | Human | Stomach | GC | 1.09e-30 | 2.95e-01 | -0.1961 |
81932 | HDHD3 | Pat09-B | Human | Stomach | GC | 9.93e-06 | 1.88e-01 | -0.0359 |
81932 | HDHD3 | Pat11-B | Human | Stomach | GC | 3.02e-11 | 3.07e-01 | -0.182 |
81932 | HDHD3 | Pat12-B | Human | Stomach | GC | 4.16e-10 | 1.53e-01 | 0.0325 |
81932 | HDHD3 | Pat13-B | Human | Stomach | GC | 1.19e-06 | 2.70e-01 | 0.0555 |
81932 | HDHD3 | Pat15-B | Human | Stomach | GC | 2.49e-15 | 4.24e-01 | -0.0778 |
81932 | HDHD3 | Pat16-B | Human | Stomach | GC | 9.52e-04 | 2.05e-01 | 0.1918 |
81932 | HDHD3 | Pat18-B | Human | Stomach | GC | 4.45e-20 | 4.41e-01 | -0.0432 |
81932 | HDHD3 | Pat19-B | Human | Stomach | GC | 7.95e-10 | 2.64e-01 | 0.0826 |
81932 | HDHD3 | Pat22-B | Human | Stomach | GC | 2.28e-35 | 4.23e-01 | -0.1042 |
81932 | HDHD3 | Pat24-B | Human | Stomach | GC | 6.09e-11 | 3.84e-01 | -0.1184 |
81932 | HDHD3 | Pat25-A | Human | Stomach | CAG with IM | 2.96e-31 | 2.14e-01 | -0.1648 |
81932 | HDHD3 | Pat26-A | Human | Stomach | CSG | 1.65e-32 | 3.89e-01 | -0.2402 |
81932 | HDHD3 | Pat28-A | Human | Stomach | CSG | 1.72e-12 | 3.28e-01 | -0.2594 |
81932 | HDHD3 | Pat29-A | Human | Stomach | CAG with IM | 7.65e-05 | 2.57e-01 | -0.2769 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HDHD3 | SNV | Missense_Mutation | novel | c.226N>A | p.Leu76Met | p.L76M | Q9BSH5 | protein_coding | tolerated(0.16) | benign(0.073) | TCGA-AR-A0TV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HDHD3 | SNV | Missense_Mutation | c.352N>A | p.Glu118Lys | p.E118K | Q9BSH5 | protein_coding | tolerated(0.84) | benign(0.01) | TCGA-LD-A74U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | taxotere | SD | |
HDHD3 | SNV | Missense_Mutation | novel | c.331N>C | p.Trp111Arg | p.W111R | Q9BSH5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HDHD3 | SNV | Missense_Mutation | rs772718812 | c.23N>A | p.Arg8Gln | p.R8Q | Q9BSH5 | protein_coding | tolerated(0.06) | benign(0.051) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HDHD3 | SNV | Missense_Mutation | rs528728306 | c.416G>A | p.Arg139Gln | p.R139Q | Q9BSH5 | protein_coding | tolerated(0.29) | benign(0.003) | TCGA-D5-6924-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HDHD3 | SNV | Missense_Mutation | rs148070774 | c.65N>A | p.Arg22His | p.R22H | Q9BSH5 | protein_coding | deleterious(0.02) | benign(0.075) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
HDHD3 | SNV | Missense_Mutation | novel | c.308N>C | p.Lys103Thr | p.K103T | Q9BSH5 | protein_coding | tolerated(0.13) | benign(0.055) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HDHD3 | SNV | Missense_Mutation | novel | c.155N>T | p.Ala52Val | p.A52V | Q9BSH5 | protein_coding | tolerated(0.29) | benign(0.069) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
HDHD3 | SNV | Missense_Mutation | novel | c.394G>A | p.Ala132Thr | p.A132T | Q9BSH5 | protein_coding | deleterious(0.01) | possibly_damaging(0.896) | TCGA-AX-A3G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HDHD3 | SNV | Missense_Mutation | novel | c.641C>T | p.Pro214Leu | p.P214L | Q9BSH5 | protein_coding | tolerated(0.1) | benign(0.005) | TCGA-CC-A5UD-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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