|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: GOLM1 |
Gene summary for GOLM1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GOLM1 | Gene ID | 51280 |
| Gene name | golgi membrane protein 1 | |
| Gene Alias | C9orf155 | |
| Cytomap | 9q21.33 | |
| Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | B3KNK9 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 51280 | GOLM1 | Pat06-B | Human | Stomach | GC | 3.87e-60 | 3.93e-01 | -0.1961 |
| 51280 | GOLM1 | Pat07-B | Human | Stomach | GC | 1.23e-04 | -2.88e-01 | 0.0935 |
| 51280 | GOLM1 | Pat09-B | Human | Stomach | GC | 3.96e-03 | -5.95e-02 | -0.0359 |
| 51280 | GOLM1 | Pat10-B | Human | Stomach | GC | 2.02e-09 | 4.10e-01 | 0.084 |
| 51280 | GOLM1 | Pat11-B | Human | Stomach | GC | 5.03e-28 | 3.13e-01 | -0.182 |
| 51280 | GOLM1 | Pat12-B | Human | Stomach | GC | 1.53e-19 | -2.04e-01 | 0.0325 |
| 51280 | GOLM1 | Pat13-B | Human | Stomach | GC | 3.59e-12 | -1.48e-01 | 0.0555 |
| 51280 | GOLM1 | Pat15-B | Human | Stomach | GC | 5.10e-23 | 4.43e-01 | -0.0778 |
| 51280 | GOLM1 | Pat16-B | Human | Stomach | GC | 5.41e-13 | -3.60e-01 | 0.1918 |
| 51280 | GOLM1 | Pat17-B | Human | Stomach | GC | 6.29e-08 | -2.87e-01 | 0.3109 |
| 51280 | GOLM1 | Pat18-B | Human | Stomach | GC | 3.84e-27 | 4.33e-01 | -0.0432 |
| 51280 | GOLM1 | Pat19-B | Human | Stomach | GC | 3.89e-20 | 3.78e-01 | 0.0826 |
| 51280 | GOLM1 | Pat22-B | Human | Stomach | GC | 8.34e-49 | 4.59e-01 | -0.1042 |
| 51280 | GOLM1 | Pat24-B | Human | Stomach | GC | 1.92e-14 | 2.24e-01 | -0.1184 |
| 51280 | GOLM1 | Pat25-A | Human | Stomach | CAG with IM | 3.08e-50 | 4.84e-01 | -0.1648 |
| 51280 | GOLM1 | Pat26-A | Human | Stomach | CSG | 2.22e-63 | 5.51e-01 | -0.2402 |
| 51280 | GOLM1 | Pat28-A | Human | Stomach | CSG | 1.58e-27 | 3.74e-01 | -0.2594 |
| 51280 | GOLM1 | Pat29-A | Human | Stomach | CAG with IM | 4.78e-21 | 4.56e-01 | -0.2769 |
| 51280 | GOLM1 | NAG_1 | Human | Stomach | CSG | 1.86e-02 | -9.35e-02 | -0.3534 |
| 51280 | GOLM1 | CAG_2 | Human | Stomach | CAG | 3.09e-02 | 3.87e-02 | -0.2831 |
| Page: 1 2 3 4 5 6 7 8 9 10 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00192165 | Endometrium | AEH | regulation of lipid metabolic process | 53/2100 | 331/18723 | 4.86e-03 | 3.07e-02 | 53 |
| GO:001921613 | Endometrium | EEC | regulation of lipid metabolic process | 54/2168 | 331/18723 | 5.82e-03 | 3.49e-02 | 54 |
| GO:000699713 | Esophagus | ESCC | nucleus organization | 96/8552 | 133/18723 | 4.66e-10 | 1.21e-08 | 96 |
| GO:00192168 | Esophagus | ESCC | regulation of lipid metabolic process | 172/8552 | 331/18723 | 1.20e-02 | 4.02e-02 | 172 |
| GO:001921611 | Liver | Cirrhotic | regulation of lipid metabolic process | 119/4634 | 331/18723 | 3.05e-06 | 5.39e-05 | 119 |
| GO:0006997 | Liver | Cirrhotic | nucleus organization | 48/4634 | 133/18723 | 2.27e-03 | 1.38e-02 | 48 |
| GO:00192162 | Liver | HCC | regulation of lipid metabolic process | 181/7958 | 331/18723 | 4.58e-06 | 5.79e-05 | 181 |
| GO:00069971 | Liver | HCC | nucleus organization | 82/7958 | 133/18723 | 6.32e-06 | 7.72e-05 | 82 |
| GO:00069974 | Oral cavity | OSCC | nucleus organization | 85/7305 | 133/18723 | 5.12e-09 | 1.12e-07 | 85 |
| GO:00192167 | Oral cavity | OSCC | regulation of lipid metabolic process | 154/7305 | 331/18723 | 3.00e-03 | 1.30e-02 | 154 |
| GO:00069972 | Prostate | BPH | nucleus organization | 38/3107 | 133/18723 | 3.69e-04 | 2.72e-03 | 38 |
| GO:000699711 | Prostate | Tumor | nucleus organization | 38/3246 | 133/18723 | 8.78e-04 | 5.89e-03 | 38 |
| GO:00192166 | Prostate | Tumor | regulation of lipid metabolic process | 76/3246 | 331/18723 | 5.04e-03 | 2.45e-02 | 76 |
| GO:0019216 | Stomach | GC | regulation of lipid metabolic process | 37/1159 | 331/18723 | 3.67e-04 | 5.70e-03 | 37 |
| GO:00192161 | Stomach | SIM | regulation of lipid metabolic process | 27/708 | 331/18723 | 1.58e-04 | 3.50e-03 | 27 |
| GO:00069977 | Thyroid | PTC | nucleus organization | 65/5968 | 133/18723 | 3.16e-05 | 3.01e-04 | 65 |
| GO:000699714 | Thyroid | ATC | nucleus organization | 65/6293 | 133/18723 | 1.87e-04 | 1.26e-03 | 65 |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| GOLM1 | SNV | Missense_Mutation | rs763578163 | c.113N>A | p.Arg38Gln | p.R38Q | Q8NBJ4 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-D8-A1XZ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen+anastrozolum | SD |
| GOLM1 | SNV | Missense_Mutation | novel | c.375N>T | p.Lys125Asn | p.K125N | Q8NBJ4 | protein_coding | tolerated(0.16) | possibly_damaging(0.813) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| GOLM1 | SNV | Missense_Mutation | rs764069710 | c.58N>A | p.Ala20Thr | p.A20T | Q8NBJ4 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| GOLM1 | SNV | Missense_Mutation | novel | c.387N>C | p.Arg129Ser | p.R129S | Q8NBJ4 | protein_coding | tolerated(0.2) | benign(0.085) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
| GOLM1 | SNV | Missense_Mutation | rs780788709 | c.160C>T | p.Arg54Cys | p.R54C | Q8NBJ4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| GOLM1 | SNV | Missense_Mutation | novel | c.740A>C | p.Lys247Thr | p.K247T | Q8NBJ4 | protein_coding | deleterious(0.02) | possibly_damaging(0.801) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| GOLM1 | SNV | Missense_Mutation | novel | c.563N>T | p.Arg188Ile | p.R188I | Q8NBJ4 | protein_coding | deleterious(0.03) | possibly_damaging(0.653) | TCGA-AG-3878-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| GOLM1 | SNV | Missense_Mutation | novel | c.741N>T | p.Lys247Asn | p.K247N | Q8NBJ4 | protein_coding | tolerated(0.07) | possibly_damaging(0.801) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| GOLM1 | insertion | Frame_Shift_Ins | novel | c.539_540insA | p.Asn182GlufsTer2 | p.N182Efs*2 | Q8NBJ4 | protein_coding | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
| GOLM1 | insertion | Frame_Shift_Ins | novel | c.539_540insT | p.Lys180AsnfsTer4 | p.K180Nfs*4 | Q8NBJ4 | protein_coding | TCGA-DM-A1D0-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |