|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: ESRP1 |
Gene summary for ESRP1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ESRP1 | Gene ID | 54845 |
| Gene name | epithelial splicing regulatory protein 1 | |
| Gene Alias | DFNB109 | |
| Cytomap | 8q22.1 | |
| Gene Type | protein-coding | GO ID | GO:0001708 | UniProtAcc | Q6NXG1 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 54845 | ESRP1 | Dong_P3 | Human | Prostate | Tumor | 8.16e-08 | 1.65e-01 | 0.0278 |
| 54845 | ESRP1 | Dong_P4 | Human | Prostate | Tumor | 1.24e-02 | 1.63e-01 | 0.0292 |
| 54845 | ESRP1 | Dong_P5 | Human | Prostate | Tumor | 4.07e-35 | 2.43e-01 | 0.053 |
| 54845 | ESRP1 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 3.23e-04 | 4.61e-01 | 0.1633 |
| 54845 | ESRP1 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 2.28e-04 | 4.30e-01 | 0.1608 |
| 54845 | ESRP1 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 1.02e-02 | 4.73e-01 | 0.1604 |
| 54845 | ESRP1 | GSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002 | Human | Prostate | Tumor | 2.97e-07 | 6.75e-01 | 0.1619 |
| 54845 | ESRP1 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 4.54e-03 | 4.12e-01 | 0.1602 |
| 54845 | ESRP1 | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 3.02e-06 | 3.95e-01 | 0.1545 |
| 54845 | ESRP1 | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 1.01e-02 | 3.10e-01 | 0.1569 |
| 54845 | ESRP1 | P1_S1_AK | Human | Skin | AK | 1.14e-05 | 2.89e-01 | -0.3399 |
| 54845 | ESRP1 | P3_S6_AK | Human | Skin | AK | 1.67e-03 | 3.06e-01 | -0.3256 |
| 54845 | ESRP1 | P4_S8_cSCC | Human | Skin | cSCC | 8.23e-06 | 2.08e-01 | -0.3095 |
| 54845 | ESRP1 | P5_S10_cSCC | Human | Skin | cSCC | 5.10e-06 | 1.65e-01 | -0.299 |
| 54845 | ESRP1 | P1_cSCC | Human | Skin | cSCC | 1.45e-34 | 8.91e-01 | 0.0292 |
| 54845 | ESRP1 | P2_cSCC | Human | Skin | cSCC | 1.87e-25 | 5.56e-01 | -0.024 |
| 54845 | ESRP1 | P4_cSCC | Human | Skin | cSCC | 3.71e-23 | 5.47e-01 | -0.00290000000000005 |
| 54845 | ESRP1 | P10_cSCC | Human | Skin | cSCC | 4.23e-35 | 9.22e-01 | 0.1017 |
| 54845 | ESRP1 | cSCC_p1 | Human | Skin | cSCC | 4.96e-05 | 2.30e-01 | -0.1916 |
| 54845 | ESRP1 | cSCC_p10 | Human | Skin | cSCC | 3.84e-04 | 2.59e-01 | -0.2095 |
| Page: 1 2 3 4 5 6 7 8 9 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00085446 | Cervix | CC | epidermis development | 83/2311 | 324/18723 | 3.91e-11 | 8.54e-09 | 83 |
| GO:00099137 | Cervix | CC | epidermal cell differentiation | 53/2311 | 202/18723 | 5.48e-08 | 3.25e-06 | 53 |
| GO:004348410 | Cervix | CC | regulation of RNA splicing | 42/2311 | 148/18723 | 1.25e-07 | 6.24e-06 | 42 |
| GO:00456822 | Cervix | CC | regulation of epidermis development | 22/2311 | 65/18723 | 5.56e-06 | 1.38e-04 | 22 |
| GO:00456042 | Cervix | CC | regulation of epidermal cell differentiation | 20/2311 | 58/18723 | 1.07e-05 | 2.33e-04 | 20 |
| GO:00308563 | Cervix | CC | regulation of epithelial cell differentiation | 36/2311 | 154/18723 | 1.02e-04 | 1.31e-03 | 36 |
| GO:000838010 | Cervix | CC | RNA splicing | 76/2311 | 434/18723 | 9.79e-04 | 8.19e-03 | 76 |
| GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
| GO:0043484 | Colorectum | AD | regulation of RNA splicing | 70/3918 | 148/18723 | 6.47e-13 | 1.16e-10 | 70 |
| GO:0035315 | Colorectum | AD | hair cell differentiation | 21/3918 | 47/18723 | 2.14e-04 | 2.82e-03 | 21 |
| GO:0042491 | Colorectum | AD | inner ear auditory receptor cell differentiation | 17/3918 | 38/18723 | 8.26e-04 | 8.13e-03 | 17 |
| GO:0042490 | Colorectum | AD | mechanoreceptor differentiation | 24/3918 | 67/18723 | 3.48e-03 | 2.52e-02 | 24 |
| GO:0009913 | Colorectum | AD | epidermal cell differentiation | 58/3918 | 202/18723 | 5.16e-03 | 3.42e-02 | 58 |
| GO:0008544 | Colorectum | AD | epidermis development | 87/3918 | 324/18723 | 5.99e-03 | 3.76e-02 | 87 |
| GO:00083801 | Colorectum | SER | RNA splicing | 123/2897 | 434/18723 | 3.84e-12 | 8.41e-10 | 123 |
| GO:00434841 | Colorectum | SER | regulation of RNA splicing | 49/2897 | 148/18723 | 7.02e-08 | 4.49e-06 | 49 |
| GO:00353151 | Colorectum | SER | hair cell differentiation | 15/2897 | 47/18723 | 3.68e-03 | 3.07e-02 | 15 |
| GO:00083802 | Colorectum | MSS | RNA splicing | 159/3467 | 434/18723 | 1.75e-19 | 1.22e-16 | 159 |
| GO:00434842 | Colorectum | MSS | regulation of RNA splicing | 66/3467 | 148/18723 | 2.44e-13 | 5.25e-11 | 66 |
| GO:00353152 | Colorectum | MSS | hair cell differentiation | 19/3467 | 47/18723 | 3.88e-04 | 4.86e-03 | 19 |
| Page: 1 2 3 4 5 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ESRP1 | TH17 | Skin | ADJ | DSP,KRT10,KRT1, etc. | 7.98e-03 |  |
| ESRP1 | CD8TRM | Skin | SCCIS | DSP,KRT10,KRT1, etc. | 2.60e-02 |  |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ESRP1 | SNV | Missense_Mutation | novel | c.1479N>G | p.Ile493Met | p.I493M | Q6NXG1 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
| ESRP1 | SNV | Missense_Mutation | novel | c.344G>T | p.Arg115Met | p.R115M | Q6NXG1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD |
| ESRP1 | SNV | Missense_Mutation | c.451N>T | p.Pro151Ser | p.P151S | Q6NXG1 | protein_coding | tolerated(0.51) | benign(0.003) | TCGA-A8-A07W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | exemestane | SD | |
| ESRP1 | SNV | Missense_Mutation | c.230C>G | p.Ser77Trp | p.S77W | Q6NXG1 | protein_coding | deleterious(0.02) | benign(0.404) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
| ESRP1 | SNV | Missense_Mutation | c.148N>A | p.Glu50Lys | p.E50K | Q6NXG1 | protein_coding | tolerated(0.61) | benign(0) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ESRP1 | SNV | Missense_Mutation | c.1496N>G | p.Asp499Gly | p.D499G | Q6NXG1 | protein_coding | deleterious(0.04) | possibly_damaging(0.882) | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
| ESRP1 | SNV | Missense_Mutation | novel | c.1651N>C | p.Cys551Arg | p.C551R | Q6NXG1 | protein_coding | tolerated(0.24) | benign(0.049) | TCGA-LL-A7SZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
| ESRP1 | SNV | Missense_Mutation | novel | c.1777N>A | p.Ala593Thr | p.A593T | Q6NXG1 | protein_coding | tolerated(0.26) | benign(0.081) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| ESRP1 | SNV | Missense_Mutation | c.1463N>T | p.Ser488Leu | p.S488L | Q6NXG1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| ESRP1 | SNV | Missense_Mutation | c.544N>C | p.Glu182Gln | p.E182Q | Q6NXG1 | protein_coding | tolerated(0.99) | benign(0.003) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |