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Gene: CYB5B |
Gene summary for CYB5B |
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Gene information | Species | Human | Gene symbol | CYB5B | Gene ID | 80777 |
Gene name | cytochrome b5 type B | |
Gene Alias | CYB5-M | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | J3KNF8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80777 | CYB5B | PTC07 | Human | Thyroid | PTC | 1.71e-29 | 2.46e-01 | 0.2044 |
80777 | CYB5B | ATC09 | Human | Thyroid | ATC | 2.76e-02 | -4.01e-02 | 0.2871 |
80777 | CYB5B | ATC11 | Human | Thyroid | ATC | 2.35e-06 | 5.72e-01 | 0.3386 |
80777 | CYB5B | ATC12 | Human | Thyroid | ATC | 1.36e-18 | 1.32e-01 | 0.34 |
80777 | CYB5B | ATC13 | Human | Thyroid | ATC | 6.95e-26 | 3.96e-01 | 0.34 |
80777 | CYB5B | ATC1 | Human | Thyroid | ATC | 1.97e-03 | -2.49e-02 | 0.2878 |
80777 | CYB5B | ATC2 | Human | Thyroid | ATC | 1.54e-09 | 1.03e+00 | 0.34 |
80777 | CYB5B | ATC3 | Human | Thyroid | ATC | 2.46e-08 | 6.34e-01 | 0.338 |
80777 | CYB5B | ATC4 | Human | Thyroid | ATC | 2.12e-16 | 2.05e-01 | 0.34 |
80777 | CYB5B | ATC5 | Human | Thyroid | ATC | 4.04e-32 | 4.58e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006091 | Colorectum | AD | generation of precursor metabolites and energy | 209/3918 | 490/18723 | 3.17e-28 | 6.61e-25 | 209 |
GO:0022900 | Colorectum | AD | electron transport chain | 89/3918 | 175/18723 | 1.42e-18 | 8.91e-16 | 89 |
GO:0006979 | Colorectum | AD | response to oxidative stress | 145/3918 | 446/18723 | 5.16e-09 | 3.23e-07 | 145 |
GO:0006809 | Colorectum | AD | nitric oxide biosynthetic process | 30/3918 | 76/18723 | 1.72e-04 | 2.33e-03 | 30 |
GO:0046209 | Colorectum | AD | nitric oxide metabolic process | 31/3918 | 81/18723 | 2.61e-04 | 3.25e-03 | 31 |
GO:0009410 | Colorectum | AD | response to xenobiotic stimulus | 128/3918 | 462/18723 | 2.69e-04 | 3.31e-03 | 128 |
GO:2001057 | Colorectum | AD | reactive nitrogen species metabolic process | 31/3918 | 82/18723 | 3.37e-04 | 3.94e-03 | 31 |
GO:00060911 | Colorectum | SER | generation of precursor metabolites and energy | 168/2897 | 490/18723 | 1.39e-25 | 1.70e-22 | 168 |
GO:00229001 | Colorectum | SER | electron transport chain | 77/2897 | 175/18723 | 1.77e-19 | 1.36e-16 | 77 |
GO:00069791 | Colorectum | SER | response to oxidative stress | 114/2897 | 446/18723 | 1.75e-08 | 1.28e-06 | 114 |
GO:00068091 | Colorectum | SER | nitric oxide biosynthetic process | 27/2897 | 76/18723 | 1.38e-05 | 4.28e-04 | 27 |
GO:00462091 | Colorectum | SER | nitric oxide metabolic process | 28/2897 | 81/18723 | 1.73e-05 | 5.15e-04 | 28 |
GO:20010571 | Colorectum | SER | reactive nitrogen species metabolic process | 28/2897 | 82/18723 | 2.24e-05 | 6.43e-04 | 28 |
GO:00060912 | Colorectum | MSS | generation of precursor metabolites and energy | 186/3467 | 490/18723 | 1.14e-24 | 2.15e-21 | 186 |
GO:00229002 | Colorectum | MSS | electron transport chain | 83/3467 | 175/18723 | 2.06e-18 | 1.17e-15 | 83 |
GO:00069792 | Colorectum | MSS | response to oxidative stress | 128/3467 | 446/18723 | 7.65e-08 | 3.81e-06 | 128 |
GO:00094101 | Colorectum | MSS | response to xenobiotic stimulus | 110/3467 | 462/18723 | 2.36e-03 | 1.92e-02 | 110 |
GO:00060914 | Colorectum | FAP | generation of precursor metabolites and energy | 128/2622 | 490/18723 | 5.58e-13 | 4.28e-10 | 128 |
GO:00229004 | Colorectum | FAP | electron transport chain | 51/2622 | 175/18723 | 1.44e-07 | 9.03e-06 | 51 |
GO:00069794 | Colorectum | FAP | response to oxidative stress | 102/2622 | 446/18723 | 2.29e-07 | 1.33e-05 | 102 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CYB5B | SNV | Missense_Mutation | novel | c.98N>T | p.Ala33Val | p.A33V | protein_coding | tolerated(0.16) | benign(0.162) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CYB5B | SNV | Missense_Mutation | novel | c.397N>A | p.Ala133Thr | p.A133T | protein_coding | deleterious(0) | benign(0.241) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
CYB5B | SNV | Missense_Mutation | rs576407250 | c.388N>G | p.Ile130Val | p.I130V | protein_coding | tolerated(0.69) | benign(0.045) | TCGA-AX-A05U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CYB5B | SNV | Missense_Mutation | c.73N>G | p.Thr25Ala | p.T25A | protein_coding | tolerated(0.07) | benign(0.121) | TCGA-D1-A17H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CYB5B | SNV | Missense_Mutation | c.149A>G | p.Tyr50Cys | p.Y50C | protein_coding | deleterious(0) | benign(0.412) | TCGA-05-5423-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
CYB5B | insertion | Frame_Shift_Ins | novel | c.188_189insAG | p.Val65ArgfsTer9 | p.V65Rfs*9 | protein_coding | TCGA-85-8276-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD | |||
CYB5B | SNV | Missense_Mutation | novel | c.292G>A | p.Asp98Asn | p.D98N | protein_coding | deleterious(0.02) | possibly_damaging(0.721) | TCGA-P3-A6T5-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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