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Gene: CORO1B |
Gene summary for CORO1B |
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Gene information | Species | Human | Gene symbol | CORO1B | Gene ID | 57175 |
Gene name | coronin 1B | |
Gene Alias | CORONIN-2 | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A0A024R5K1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57175 | CORO1B | P10_cSCC | Human | Skin | cSCC | 4.35e-27 | 9.03e-01 | 0.1017 |
57175 | CORO1B | cSCC_p8 | Human | Skin | cSCC | 1.85e-02 | 1.08e-01 | -0.1971 |
57175 | CORO1B | male-WTA | Human | Thyroid | PTC | 1.93e-41 | 5.32e-01 | 0.1037 |
57175 | CORO1B | PTC01 | Human | Thyroid | PTC | 6.05e-23 | 5.41e-01 | 0.1899 |
57175 | CORO1B | PTC03 | Human | Thyroid | PTC | 2.06e-07 | 3.63e-01 | 0.1784 |
57175 | CORO1B | PTC04 | Human | Thyroid | PTC | 1.58e-15 | 4.15e-01 | 0.1927 |
57175 | CORO1B | PTC05 | Human | Thyroid | PTC | 6.03e-38 | 1.18e+00 | 0.2065 |
57175 | CORO1B | PTC06 | Human | Thyroid | PTC | 8.55e-62 | 1.18e+00 | 0.2057 |
57175 | CORO1B | PTC07 | Human | Thyroid | PTC | 7.75e-66 | 9.83e-01 | 0.2044 |
57175 | CORO1B | ATC09 | Human | Thyroid | ATC | 9.42e-28 | 1.14e+00 | 0.2871 |
57175 | CORO1B | ATC11 | Human | Thyroid | ATC | 4.45e-08 | 7.61e-01 | 0.3386 |
57175 | CORO1B | ATC12 | Human | Thyroid | ATC | 1.79e-31 | 6.69e-01 | 0.34 |
57175 | CORO1B | ATC13 | Human | Thyroid | ATC | 1.13e-23 | 5.28e-01 | 0.34 |
57175 | CORO1B | ATC1 | Human | Thyroid | ATC | 5.90e-29 | 1.32e+00 | 0.2878 |
57175 | CORO1B | ATC2 | Human | Thyroid | ATC | 5.35e-23 | 1.40e+00 | 0.34 |
57175 | CORO1B | ATC3 | Human | Thyroid | ATC | 3.78e-13 | 7.30e-01 | 0.338 |
57175 | CORO1B | ATC4 | Human | Thyroid | ATC | 1.79e-39 | 8.30e-01 | 0.34 |
57175 | CORO1B | ATC5 | Human | Thyroid | ATC | 9.37e-26 | 5.64e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0032535 | Colorectum | AD | regulation of cellular component size | 142/3918 | 383/18723 | 1.74e-13 | 3.41e-11 | 142 |
GO:1902903 | Colorectum | AD | regulation of supramolecular fiber organization | 139/3918 | 383/18723 | 2.01e-12 | 3.19e-10 | 139 |
GO:0032970 | Colorectum | AD | regulation of actin filament-based process | 142/3918 | 397/18723 | 4.05e-12 | 5.90e-10 | 142 |
GO:0110053 | Colorectum | AD | regulation of actin filament organization | 108/3918 | 278/18723 | 5.02e-12 | 6.98e-10 | 108 |
GO:0008154 | Colorectum | AD | actin polymerization or depolymerization | 90/3918 | 218/18723 | 6.14e-12 | 8.23e-10 | 90 |
GO:0032271 | Colorectum | AD | regulation of protein polymerization | 94/3918 | 233/18723 | 1.01e-11 | 1.29e-09 | 94 |
GO:0030041 | Colorectum | AD | actin filament polymerization | 81/3918 | 191/18723 | 1.35e-11 | 1.69e-09 | 81 |
GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0008064 | Colorectum | AD | regulation of actin polymerization or depolymerization | 79/3918 | 188/18723 | 4.17e-11 | 4.74e-09 | 79 |
GO:0030833 | Colorectum | AD | regulation of actin filament polymerization | 74/3918 | 172/18723 | 4.50e-11 | 5.03e-09 | 74 |
GO:0030832 | Colorectum | AD | regulation of actin filament length | 79/3918 | 189/18723 | 5.71e-11 | 6.27e-09 | 79 |
GO:1902905 | Colorectum | AD | positive regulation of supramolecular fiber organization | 85/3918 | 209/18723 | 5.95e-11 | 6.33e-09 | 85 |
GO:0032956 | Colorectum | AD | regulation of actin cytoskeleton organization | 127/3918 | 358/18723 | 1.03e-10 | 1.04e-08 | 127 |
GO:0051495 | Colorectum | AD | positive regulation of cytoskeleton organization | 89/3918 | 226/18723 | 1.61e-10 | 1.56e-08 | 89 |
GO:0032273 | Colorectum | AD | positive regulation of protein polymerization | 62/3918 | 138/18723 | 1.94e-10 | 1.76e-08 | 62 |
GO:0031334 | Colorectum | AD | positive regulation of protein-containing complex assembly | 91/3918 | 237/18723 | 4.78e-10 | 3.99e-08 | 91 |
GO:0030838 | Colorectum | AD | positive regulation of actin filament polymerization | 48/3918 | 99/18723 | 9.21e-10 | 7.03e-08 | 48 |
GO:0022604 | Colorectum | AD | regulation of cell morphogenesis | 109/3918 | 309/18723 | 3.08e-09 | 2.07e-07 | 109 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CORO1B | SNV | Missense_Mutation | c.1385N>A | p.Ala462Asp | p.A462D | Q9BR76 | protein_coding | tolerated(0.21) | benign(0.001) | TCGA-AR-A2LK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | anastrozole | PD | |
CORO1B | SNV | Missense_Mutation | rs757671047 | c.209N>A | p.Arg70His | p.R70H | Q9BR76 | protein_coding | deleterious(0.02) | possibly_damaging(0.684) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CORO1B | SNV | Missense_Mutation | c.619N>T | p.Arg207Trp | p.R207W | Q9BR76 | protein_coding | deleterious(0) | possibly_damaging(0.821) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
CORO1B | SNV | Missense_Mutation | rs767771419 | c.1003G>A | p.Ala335Thr | p.A335T | Q9BR76 | protein_coding | tolerated(0.07) | benign(0.281) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CORO1B | SNV | Missense_Mutation | rs772528176 | c.1148N>A | p.Arg383Gln | p.R383Q | Q9BR76 | protein_coding | tolerated(0.39) | benign(0) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CORO1B | SNV | Missense_Mutation | rs769428845 | c.286N>A | p.Glu96Lys | p.E96K | Q9BR76 | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CORO1B | SNV | Missense_Mutation | c.517N>G | p.Ser173Gly | p.S173G | Q9BR76 | protein_coding | tolerated(0.26) | benign(0.003) | TCGA-AH-6897-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CORO1B | insertion | In_Frame_Ins | novel | c.562_563insTCAGCTGGAACCACAATG | p.Val182_Asn187dup | p.V182_N187dup | Q9BR76 | protein_coding | TCGA-G5-6233-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PD | ||
CORO1B | SNV | Missense_Mutation | novel | c.81N>T | p.Glu27Asp | p.E27D | Q9BR76 | protein_coding | tolerated(1) | benign(0) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CORO1B | SNV | Missense_Mutation | novel | c.236N>A | p.Cys79Tyr | p.C79Y | Q9BR76 | protein_coding | deleterious(0.01) | probably_damaging(0.954) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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