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Gene: ATP5B |
Gene summary for ATP5B |
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Gene information | Species | Human | Gene symbol | ATP5B | Gene ID | 506 |
Gene name | ATP synthase F1 subunit beta | |
Gene Alias | ATP5B | |
Cytomap | 12q13.3 | |
Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | P06576 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
506 | ATP5B | P130T-E | Human | Esophagus | ESCC | 4.85e-87 | 3.56e+00 | 0.1676 |
506 | ATP5B | S41 | Human | Liver | Cirrhotic | 5.88e-04 | -7.07e-01 | -0.0343 |
506 | ATP5B | S43 | Human | Liver | Cirrhotic | 5.89e-29 | -7.07e-01 | -0.0187 |
506 | ATP5B | HCC1_Meng | Human | Liver | HCC | 8.07e-50 | 4.38e-01 | 0.0246 |
506 | ATP5B | HCC2_Meng | Human | Liver | HCC | 1.55e-49 | -5.72e-03 | 0.0107 |
506 | ATP5B | cirrhotic1 | Human | Liver | Cirrhotic | 8.62e-24 | 3.77e-01 | 0.0202 |
506 | ATP5B | cirrhotic2 | Human | Liver | Cirrhotic | 1.83e-32 | 5.64e-01 | 0.0201 |
506 | ATP5B | cirrhotic3 | Human | Liver | Cirrhotic | 6.98e-21 | 2.53e-01 | 0.0215 |
506 | ATP5B | HCC1 | Human | Liver | HCC | 1.76e-26 | 6.25e+00 | 0.5336 |
506 | ATP5B | HCC2 | Human | Liver | HCC | 1.19e-45 | 7.39e+00 | 0.5341 |
506 | ATP5B | Pt13.a | Human | Liver | HCC | 3.77e-10 | 3.20e-01 | 0.021 |
506 | ATP5B | Pt13.b | Human | Liver | HCC | 4.38e-51 | 5.23e-01 | 0.0251 |
506 | ATP5B | Pt14.a | Human | Liver | HCC | 4.15e-07 | 3.18e-01 | 0.0169 |
506 | ATP5B | Pt14.b | Human | Liver | HCC | 6.91e-16 | 4.89e-01 | 0.018 |
506 | ATP5B | Pt14.d | Human | Liver | HCC | 5.58e-03 | 2.04e-02 | 0.0143 |
506 | ATP5B | S014 | Human | Liver | HCC | 1.50e-17 | -7.07e-01 | 0.2254 |
506 | ATP5B | S015 | Human | Liver | HCC | 2.09e-12 | -7.07e-01 | 0.2375 |
506 | ATP5B | S016 | Human | Liver | HCC | 6.53e-22 | -7.07e-01 | 0.2243 |
506 | ATP5B | S027 | Human | Liver | HCC | 5.88e-04 | -7.07e-01 | 0.2446 |
506 | ATP5B | S028 | Human | Liver | HCC | 6.72e-14 | -7.07e-01 | 0.2503 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502016 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019016 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501416 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520818 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541518 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502017 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019017 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501417 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520819 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471419 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541519 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP5B | SNV | Missense_Mutation | c.460N>A | p.Glu154Lys | p.E154K | P06576 | protein_coding | deleterious_low_confidence(0) | benign(0.323) | TCGA-A8-A07W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | exemestane | SD | |
ATP5B | SNV | Missense_Mutation | c.1030G>C | p.Glu344Gln | p.E344Q | P06576 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.977) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR | |
ATP5B | deletion | Frame_Shift_Del | novel | c.1088delN | p.Pro363LeufsTer5 | p.P363Lfs*5 | P06576 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ATP5B | SNV | Missense_Mutation | rs2293450 | c.74N>T | p.Ser25Leu | p.S25L | P06576 | protein_coding | tolerated_low_confidence(0.78) | benign(0.005) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP5B | SNV | Missense_Mutation | novel | c.1360N>A | p.Val454Met | p.V454M | P06576 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.927) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP5B | SNV | Missense_Mutation | rs777770019 | c.1255N>A | p.Asp419Asn | p.D419N | P06576 | protein_coding | tolerated_low_confidence(0.5) | benign(0.001) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ATP5B | SNV | Missense_Mutation | c.298G>A | p.Ala100Thr | p.A100T | P06576 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.75) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ATP5B | SNV | Missense_Mutation | c.968N>A | p.Gly323Asp | p.G323D | P06576 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.957) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ATP5B | SNV | Missense_Mutation | c.992A>G | p.Tyr331Cys | p.Y331C | P06576 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.997) | TCGA-DM-A28E-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ATP5B | SNV | Missense_Mutation | c.1124N>T | p.Thr375Met | p.T375M | P06576 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-DM-A28G-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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