![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ANXA4 |
Gene summary for ANXA4 |
![]() |
Gene information | Species | Human | Gene symbol | ANXA4 | Gene ID | 307 |
Gene name | annexin A4 | |
Gene Alias | ANX4 | |
Cytomap | 2p13.3 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | P09525 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
307 | ANXA4 | LN46 | Human | Oral cavity | OSCC | 1.84e-24 | 1.18e+00 | 0.1666 |
307 | ANXA4 | LP15 | Human | Oral cavity | LP | 2.62e-12 | 1.86e+00 | 0.2174 |
307 | ANXA4 | LP17 | Human | Oral cavity | LP | 1.77e-07 | 1.10e+00 | 0.2349 |
307 | ANXA4 | SYSMH1 | Human | Oral cavity | OSCC | 1.61e-28 | 8.91e-01 | 0.1127 |
307 | ANXA4 | SYSMH2 | Human | Oral cavity | OSCC | 1.60e-37 | 1.55e+00 | 0.2326 |
307 | ANXA4 | SYSMH3 | Human | Oral cavity | OSCC | 8.66e-32 | 1.25e+00 | 0.2442 |
307 | ANXA4 | SYSMH4 | Human | Oral cavity | OSCC | 1.16e-08 | 3.87e-01 | 0.1226 |
307 | ANXA4 | SYSMH6 | Human | Oral cavity | OSCC | 9.31e-06 | 6.79e-01 | 0.1275 |
307 | ANXA4 | P4_S8_cSCC | Human | Skin | cSCC | 2.67e-08 | 1.92e-01 | -0.3095 |
307 | ANXA4 | P5_S10_cSCC | Human | Skin | cSCC | 4.43e-06 | 8.08e-02 | -0.299 |
307 | ANXA4 | P1_cSCC | Human | Skin | cSCC | 1.29e-37 | 1.39e+00 | 0.0292 |
307 | ANXA4 | P2_cSCC | Human | Skin | cSCC | 4.13e-14 | 6.87e-01 | -0.024 |
307 | ANXA4 | P4_cSCC | Human | Skin | cSCC | 1.15e-31 | 8.95e-01 | -0.00290000000000005 |
307 | ANXA4 | P10_cSCC | Human | Skin | cSCC | 7.36e-27 | 1.02e+00 | 0.1017 |
307 | ANXA4 | cSCC_p7 | Human | Skin | cSCC | 2.24e-04 | -2.71e-01 | -0.2332 |
307 | ANXA4 | cSCC_p8 | Human | Skin | cSCC | 1.38e-02 | -2.59e-02 | -0.1971 |
307 | ANXA4 | cSCC_p9 | Human | Skin | cSCC | 1.94e-03 | -7.83e-02 | -0.1991 |
307 | ANXA4 | Pat01-B | Human | Stomach | GC | 4.69e-28 | 1.51e-01 | 0.5754 |
307 | ANXA4 | Pat02-B | Human | Stomach | GC | 5.34e-53 | 2.90e-01 | 0.0368 |
307 | ANXA4 | Pat03-B | Human | Stomach | GC | 4.15e-25 | 1.68e-01 | 0.3693 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007219 | Colorectum | AD | Notch signaling pathway | 50/3918 | 172/18723 | 6.92e-03 | 4.26e-02 | 50 |
GO:0051090 | Colorectum | MSS | regulation of DNA-binding transcription factor activity | 106/3467 | 440/18723 | 1.88e-03 | 1.65e-02 | 106 |
GO:00072191 | Colorectum | FAP | Notch signaling pathway | 38/2622 | 172/18723 | 2.56e-03 | 2.01e-02 | 38 |
GO:00510901 | Colorectum | FAP | regulation of DNA-binding transcription factor activity | 80/2622 | 440/18723 | 7.90e-03 | 4.67e-02 | 80 |
GO:00072192 | Colorectum | CRC | Notch signaling pathway | 36/2078 | 172/18723 | 1.26e-04 | 2.42e-03 | 36 |
GO:00510908 | Esophagus | ESCC | regulation of DNA-binding transcription factor activity | 252/8552 | 440/18723 | 5.22e-07 | 6.97e-06 | 252 |
GO:00072197 | Esophagus | ESCC | Notch signaling pathway | 106/8552 | 172/18723 | 1.74e-05 | 1.55e-04 | 106 |
GO:00434332 | Esophagus | ESCC | negative regulation of DNA-binding transcription factor activity | 103/8552 | 185/18723 | 3.86e-03 | 1.57e-02 | 103 |
GO:00320882 | Esophagus | ESCC | negative regulation of NF-kappaB transcription factor activity | 54/8552 | 93/18723 | 1.08e-02 | 3.67e-02 | 54 |
GO:00510902 | Liver | HCC | regulation of DNA-binding transcription factor activity | 220/7958 | 440/18723 | 8.04e-04 | 4.82e-03 | 220 |
GO:00510907 | Oral cavity | OSCC | regulation of DNA-binding transcription factor activity | 221/7305 | 440/18723 | 9.06e-07 | 1.23e-05 | 221 |
GO:00072196 | Oral cavity | OSCC | Notch signaling pathway | 92/7305 | 172/18723 | 7.84e-05 | 6.08e-04 | 92 |
GO:0032088 | Oral cavity | OSCC | negative regulation of NF-kappaB transcription factor activity | 47/7305 | 93/18723 | 1.55e-02 | 4.99e-02 | 47 |
GO:005109015 | Oral cavity | LP | regulation of DNA-binding transcription factor activity | 147/4623 | 440/18723 | 2.00e-05 | 3.35e-04 | 147 |
GO:0043433 | Oral cavity | LP | negative regulation of DNA-binding transcription factor activity | 61/4623 | 185/18723 | 6.68e-03 | 3.89e-02 | 61 |
GO:000721913 | Oral cavity | LP | Notch signaling pathway | 57/4623 | 172/18723 | 7.60e-03 | 4.18e-02 | 57 |
GO:000721922 | Skin | cSCC | Notch signaling pathway | 60/4864 | 172/18723 | 5.82e-03 | 2.87e-02 | 60 |
GO:0032677 | Stomach | CAG | regulation of interleukin-8 production | 10/552 | 102/18723 | 8.58e-04 | 1.28e-02 | 10 |
GO:0032637 | Stomach | CAG | interleukin-8 production | 10/552 | 103/18723 | 9.26e-04 | 1.37e-02 | 10 |
GO:00326771 | Stomach | WIM | regulation of interleukin-8 production | 9/426 | 102/18723 | 5.32e-04 | 9.21e-03 | 9 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANXA4 | SNV | Missense_Mutation | novel | c.205N>A | p.Asp69Asn | p.D69N | P09525 | protein_coding | deleterious(0.01) | probably_damaging(0.988) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ANXA4 | SNV | Missense_Mutation | c.303G>A | p.Met101Ile | p.M101I | P09525 | protein_coding | tolerated(0.76) | benign(0.007) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ANXA4 | SNV | Missense_Mutation | c.850N>A | p.Asp284Asn | p.D284N | P09525 | protein_coding | tolerated(0.15) | probably_damaging(0.924) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
ANXA4 | SNV | Missense_Mutation | rs770362785 | c.374G>A | p.Arg125His | p.R125H | P09525 | protein_coding | deleterious(0.05) | benign(0.001) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ANXA4 | SNV | Missense_Mutation | novel | c.380G>A | p.Ser127Asn | p.S127N | P09525 | protein_coding | tolerated(0.71) | benign(0) | TCGA-VS-A8QA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ANXA4 | SNV | Missense_Mutation | rs376382183 | c.112G>A | p.Ala38Thr | p.A38T | P09525 | protein_coding | tolerated(0.23) | benign(0.04) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ANXA4 | SNV | Missense_Mutation | c.680A>C | p.Lys227Thr | p.K227T | P09525 | protein_coding | tolerated(0.07) | possibly_damaging(0.782) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ANXA4 | SNV | Missense_Mutation | c.655N>G | p.Gln219Glu | p.Q219E | P09525 | protein_coding | tolerated(0.06) | benign(0.007) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ANXA4 | SNV | Missense_Mutation | c.827N>T | p.Ser276Phe | p.S276F | P09525 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-CM-5864-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ANXA4 | SNV | Missense_Mutation | rs778785400 | c.314N>A | p.Gly105Asp | p.G105D | P09525 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |