![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ABHD3 |
Gene summary for ABHD3 |
![]() |
Gene information | Species | Human | Gene symbol | ABHD3 | Gene ID | 171586 |
Gene name | abhydrolase domain containing 3, phospholipase | |
Gene Alias | LABH3 | |
Cytomap | 18q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | J3KTE1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
171586 | ABHD3 | Pat13-B | Human | Stomach | GC | 1.87e-07 | 3.56e-01 | 0.0555 |
171586 | ABHD3 | Pat15-B | Human | Stomach | GC | 1.90e-05 | 2.78e-01 | -0.0778 |
171586 | ABHD3 | Pat16-B | Human | Stomach | GC | 7.91e-05 | 2.09e-01 | 0.1918 |
171586 | ABHD3 | Pat17-B | Human | Stomach | GC | 1.06e-03 | 2.27e-01 | 0.3109 |
171586 | ABHD3 | Pat18-B | Human | Stomach | GC | 1.09e-03 | 1.91e-01 | -0.0432 |
171586 | ABHD3 | Pat19-B | Human | Stomach | GC | 1.05e-07 | 3.46e-01 | 0.0826 |
171586 | ABHD3 | Pat22-B | Human | Stomach | GC | 1.88e-22 | 3.60e-01 | -0.1042 |
171586 | ABHD3 | Pat24-B | Human | Stomach | GC | 2.17e-11 | 4.14e-01 | -0.1184 |
171586 | ABHD3 | Pat25-A | Human | Stomach | CAG with IM | 7.02e-16 | 1.84e-01 | -0.1648 |
171586 | ABHD3 | Pat26-A | Human | Stomach | CSG | 5.75e-11 | 1.46e-01 | -0.2402 |
171586 | ABHD3 | Pat28-A | Human | Stomach | CSG | 4.11e-02 | 1.22e-01 | -0.2594 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
GO:0009062 | Colorectum | AD | fatty acid catabolic process | 41/3918 | 100/18723 | 4.02e-06 | 1.09e-04 | 41 |
GO:0016042 | Colorectum | AD | lipid catabolic process | 97/3918 | 320/18723 | 4.31e-05 | 7.56e-04 | 97 |
GO:0006631 | Colorectum | AD | fatty acid metabolic process | 114/3918 | 390/18723 | 5.58e-05 | 9.44e-04 | 114 |
GO:0072329 | Colorectum | AD | monocarboxylic acid catabolic process | 44/3918 | 122/18723 | 8.05e-05 | 1.28e-03 | 44 |
GO:0016054 | Colorectum | AD | organic acid catabolic process | 73/3918 | 240/18723 | 3.20e-04 | 3.81e-03 | 73 |
GO:0044242 | Colorectum | AD | cellular lipid catabolic process | 66/3918 | 214/18723 | 3.96e-04 | 4.50e-03 | 66 |
GO:0046395 | Colorectum | AD | carboxylic acid catabolic process | 70/3918 | 236/18723 | 9.06e-04 | 8.71e-03 | 70 |
GO:0006650 | Colorectum | AD | glycerophospholipid metabolic process | 83/3918 | 306/18723 | 5.40e-03 | 3.55e-02 | 83 |
GO:0006644 | Colorectum | AD | phospholipid metabolic process | 101/3918 | 383/18723 | 5.80e-03 | 3.67e-02 | 101 |
GO:0045017 | Colorectum | AD | glycerolipid biosynthetic process | 69/3918 | 252/18723 | 8.33e-03 | 4.88e-02 | 69 |
GO:00160421 | Colorectum | SER | lipid catabolic process | 77/2897 | 320/18723 | 3.52e-05 | 9.18e-04 | 77 |
GO:00442821 | Colorectum | SER | small molecule catabolic process | 87/2897 | 376/18723 | 5.31e-05 | 1.27e-03 | 87 |
GO:00090621 | Colorectum | SER | fatty acid catabolic process | 31/2897 | 100/18723 | 7.09e-05 | 1.61e-03 | 31 |
GO:00723291 | Colorectum | SER | monocarboxylic acid catabolic process | 34/2897 | 122/18723 | 3.27e-04 | 5.22e-03 | 34 |
GO:00442421 | Colorectum | SER | cellular lipid catabolic process | 51/2897 | 214/18723 | 8.60e-04 | 1.05e-02 | 51 |
GO:0046486 | Colorectum | SER | glycerolipid metabolic process | 82/2897 | 392/18723 | 2.26e-03 | 2.17e-02 | 82 |
GO:00066441 | Colorectum | SER | phospholipid metabolic process | 79/2897 | 383/18723 | 3.94e-03 | 3.24e-02 | 79 |
GO:00160541 | Colorectum | SER | organic acid catabolic process | 53/2897 | 240/18723 | 4.04e-03 | 3.30e-02 | 53 |
GO:00450171 | Colorectum | SER | glycerolipid biosynthetic process | 55/2897 | 252/18723 | 4.47e-03 | 3.56e-02 | 55 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ABHD3 | SNV | Missense_Mutation | c.926N>T | p.Thr309Ile | p.T309I | Q8WU67 | protein_coding | deleterious(0.04) | possibly_damaging(0.702) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
ABHD3 | SNV | Missense_Mutation | c.189N>T | p.Glu63Asp | p.E63D | Q8WU67 | protein_coding | tolerated(0.3) | benign(0.001) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ABHD3 | SNV | Missense_Mutation | c.74N>A | p.Val25Glu | p.V25E | Q8WU67 | protein_coding | tolerated(0.1) | benign(0.007) | TCGA-AF-A56L-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
ABHD3 | SNV | Missense_Mutation | c.1073C>T | p.Thr358Ile | p.T358I | Q8WU67 | protein_coding | tolerated(0.12) | benign(0.021) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ABHD3 | SNV | Missense_Mutation | c.469A>C | p.Ile157Leu | p.I157L | Q8WU67 | protein_coding | deleterious(0.02) | possibly_damaging(0.53) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ABHD3 | SNV | Missense_Mutation | novel | c.448N>A | p.Gly150Arg | p.G150R | Q8WU67 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ABHD3 | SNV | Missense_Mutation | novel | c.448N>A | p.Gly150Arg | p.G150R | Q8WU67 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0GG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ABHD3 | SNV | Missense_Mutation | novel | c.662N>C | p.Met221Thr | p.M221T | Q8WU67 | protein_coding | deleterious(0) | possibly_damaging(0.864) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ABHD3 | SNV | Missense_Mutation | c.842N>G | p.Lys281Arg | p.K281R | Q8WU67 | protein_coding | tolerated(1) | benign(0.003) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ABHD3 | SNV | Missense_Mutation | novel | c.223N>A | p.Val75Met | p.V75M | Q8WU67 | protein_coding | deleterious(0.03) | benign(0.371) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |