![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TBCB |
Gene summary for TBCB |
![]() |
Gene information | Species | Human | Gene symbol | TBCB | Gene ID | 1155 |
Gene name | tubulin folding cofactor B | |
Gene Alias | CG22 | |
Cytomap | 19q13.12 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | Q99426 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1155 | TBCB | P89T-E | Human | Esophagus | ESCC | 1.66e-29 | 2.74e+00 | 0.1752 |
1155 | TBCB | P91T-E | Human | Esophagus | ESCC | 2.16e-19 | 2.51e+00 | 0.1828 |
1155 | TBCB | P107T-E | Human | Esophagus | ESCC | 4.30e-73 | 2.02e+00 | 0.171 |
1155 | TBCB | P126T-E | Human | Esophagus | ESCC | 1.52e-19 | 1.78e+00 | 0.1125 |
1155 | TBCB | P127T-E | Human | Esophagus | ESCC | 2.65e-27 | 7.81e-01 | 0.0826 |
1155 | TBCB | P128T-E | Human | Esophagus | ESCC | 1.03e-55 | 2.19e+00 | 0.1241 |
1155 | TBCB | P130T-E | Human | Esophagus | ESCC | 8.08e-105 | 2.50e+00 | 0.1676 |
1155 | TBCB | S43 | Human | Liver | Cirrhotic | 2.09e-11 | -3.36e-01 | -0.0187 |
1155 | TBCB | HCC1_Meng | Human | Liver | HCC | 3.43e-73 | 1.30e-01 | 0.0246 |
1155 | TBCB | HCC2_Meng | Human | Liver | HCC | 8.82e-29 | 4.10e-03 | 0.0107 |
1155 | TBCB | cirrhotic1 | Human | Liver | Cirrhotic | 2.29e-25 | 2.62e-01 | 0.0202 |
1155 | TBCB | cirrhotic2 | Human | Liver | Cirrhotic | 1.22e-14 | 2.26e-01 | 0.0201 |
1155 | TBCB | cirrhotic3 | Human | Liver | Cirrhotic | 1.37e-23 | 3.76e-01 | 0.0215 |
1155 | TBCB | HCC1 | Human | Liver | HCC | 2.99e-07 | 4.56e+00 | 0.5336 |
1155 | TBCB | HCC2 | Human | Liver | HCC | 7.87e-14 | 4.27e+00 | 0.5341 |
1155 | TBCB | Pt13.b | Human | Liver | HCC | 1.39e-22 | 3.22e-01 | 0.0251 |
1155 | TBCB | Pt14.a | Human | Liver | HCC | 5.18e-04 | 2.53e-01 | 0.0169 |
1155 | TBCB | Pt14.b | Human | Liver | HCC | 8.02e-09 | 2.97e-01 | 0.018 |
1155 | TBCB | S014 | Human | Liver | HCC | 6.11e-31 | 1.72e+00 | 0.2254 |
1155 | TBCB | S015 | Human | Liver | HCC | 1.59e-37 | 2.44e+00 | 0.2375 |
Page: 1 2 3 4 5 6 7 8 9 10 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TBCB | SNV | Missense_Mutation | novel | c.166N>G | p.Leu56Val | p.L56V | Q99426 | protein_coding | tolerated(0.62) | benign(0.13) | TCGA-C5-A7CK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
TBCB | SNV | Missense_Mutation | rs374667464 | c.635N>A | p.Arg212His | p.R212H | Q99426 | protein_coding | deleterious(0.04) | probably_damaging(0.921) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TBCB | SNV | Missense_Mutation | c.193N>G | p.Ser65Gly | p.S65G | Q99426 | protein_coding | tolerated(0.43) | benign(0) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TBCB | SNV | Missense_Mutation | novel | c.185A>C | p.Lys62Thr | p.K62T | Q99426 | protein_coding | tolerated(0.05) | benign(0.025) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TBCB | SNV | Missense_Mutation | c.239N>G | p.Asp80Gly | p.D80G | Q99426 | protein_coding | deleterious(0.01) | possibly_damaging(0.652) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TBCB | SNV | Missense_Mutation | rs371592763 | c.301N>A | p.Val101Met | p.V101M | Q99426 | protein_coding | tolerated(0.09) | benign(0.028) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TBCB | SNV | Missense_Mutation | rs750629354 | c.587N>A | p.Arg196His | p.R196H | Q99426 | protein_coding | tolerated(0.08) | benign(0.015) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TBCB | SNV | Missense_Mutation | c.210N>T | p.Glu70Asp | p.E70D | Q99426 | protein_coding | tolerated(1) | benign(0) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
TBCB | SNV | Missense_Mutation | novel | c.617N>A | p.Gly206Asp | p.G206D | Q99426 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
TBCB | SNV | Missense_Mutation | c.643N>A | p.Glu215Lys | p.E215K | Q99426 | protein_coding | deleterious(0.01) | benign(0.288) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |