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Gene: TBC1D22A |
Gene summary for TBC1D22A |
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Gene information | Species | Human | Gene symbol | TBC1D22A | Gene ID | 25771 |
Gene name | TBC1 domain family member 22A | |
Gene Alias | C22orf4 | |
Cytomap | 22q13.31 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8WUA7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25771 | TBC1D22A | HCC2_Meng | Human | Liver | HCC | 1.31e-17 | -1.20e-02 | 0.0107 |
25771 | TBC1D22A | HCC1 | Human | Liver | HCC | 1.71e-03 | 3.71e+00 | 0.5336 |
25771 | TBC1D22A | HCC2 | Human | Liver | HCC | 1.71e-06 | 2.94e+00 | 0.5341 |
25771 | TBC1D22A | HCC5 | Human | Liver | HCC | 3.76e-03 | 1.54e+00 | 0.4932 |
25771 | TBC1D22A | S014 | Human | Liver | HCC | 4.68e-03 | 3.22e-01 | 0.2254 |
25771 | TBC1D22A | S015 | Human | Liver | HCC | 1.25e-06 | 5.43e-01 | 0.2375 |
25771 | TBC1D22A | S016 | Human | Liver | HCC | 2.48e-06 | 4.07e-01 | 0.2243 |
25771 | TBC1D22A | S028 | Human | Liver | HCC | 1.68e-08 | 4.95e-01 | 0.2503 |
25771 | TBC1D22A | S029 | Human | Liver | HCC | 1.31e-03 | 3.06e-01 | 0.2581 |
25771 | TBC1D22A | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 2.66e-04 | 7.47e-01 | -0.1408 |
25771 | TBC1D22A | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 1.73e-03 | 7.84e-01 | -0.138 |
25771 | TBC1D22A | RNA-P17T-P17T-2 | Human | Lung | IAC | 1.66e-03 | 4.49e-01 | 0.3371 |
25771 | TBC1D22A | RNA-P24T2-P24T2-2 | Human | Lung | IAC | 1.14e-03 | 1.24e+00 | 0.0057 |
25771 | TBC1D22A | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 3.69e-21 | 8.87e-01 | -0.2116 |
25771 | TBC1D22A | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 4.12e-06 | 7.65e-01 | -0.1941 |
25771 | TBC1D22A | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 5.87e-09 | 8.15e-01 | -0.2107 |
25771 | TBC1D22A | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 1.27e-17 | 7.90e-01 | -0.2119 |
25771 | TBC1D22A | RNA-P3T-P3T-1 | Human | Lung | IAC | 2.04e-02 | 3.85e-01 | 0.1829 |
25771 | TBC1D22A | RNA-P3T-P3T-4 | Human | Lung | IAC | 3.76e-06 | 5.41e-01 | 0.1859 |
25771 | TBC1D22A | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 3.52e-02 | 5.70e-01 | -0.0296 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00430877 | Cervix | CC | regulation of GTPase activity | 79/2311 | 348/18723 | 4.21e-08 | 2.60e-06 | 79 |
GO:00435476 | Cervix | CC | positive regulation of GTPase activity | 53/2311 | 255/18723 | 8.72e-05 | 1.16e-03 | 53 |
GO:0043087 | Colorectum | AD | regulation of GTPase activity | 110/3918 | 348/18723 | 1.64e-06 | 5.03e-05 | 110 |
GO:0043547 | Colorectum | AD | positive regulation of GTPase activity | 75/3918 | 255/18723 | 7.95e-04 | 7.91e-03 | 75 |
GO:00430872 | Colorectum | MSS | regulation of GTPase activity | 101/3467 | 348/18723 | 1.00e-06 | 3.46e-05 | 101 |
GO:00435471 | Colorectum | MSS | positive regulation of GTPase activity | 68/3467 | 255/18723 | 7.97e-04 | 8.38e-03 | 68 |
GO:00430873 | Colorectum | FAP | regulation of GTPase activity | 85/2622 | 348/18723 | 1.20e-07 | 7.68e-06 | 85 |
GO:00435472 | Colorectum | FAP | positive regulation of GTPase activity | 61/2622 | 255/18723 | 1.39e-05 | 3.73e-04 | 61 |
GO:0090630 | Colorectum | FAP | activation of GTPase activity | 27/2622 | 115/18723 | 4.23e-03 | 2.90e-02 | 27 |
GO:00430874 | Colorectum | CRC | regulation of GTPase activity | 69/2078 | 348/18723 | 1.11e-06 | 6.69e-05 | 69 |
GO:00435473 | Colorectum | CRC | positive regulation of GTPase activity | 49/2078 | 255/18723 | 8.67e-05 | 1.77e-03 | 49 |
GO:00430878 | Endometrium | AEH | regulation of GTPase activity | 66/2100 | 348/18723 | 1.26e-05 | 2.77e-04 | 66 |
GO:00435477 | Endometrium | AEH | positive regulation of GTPase activity | 48/2100 | 255/18723 | 2.18e-04 | 2.67e-03 | 48 |
GO:00906304 | Endometrium | AEH | activation of GTPase activity | 22/2100 | 115/18723 | 8.42e-03 | 4.60e-02 | 22 |
GO:004308712 | Endometrium | EEC | regulation of GTPase activity | 67/2168 | 348/18723 | 1.84e-05 | 3.43e-04 | 67 |
GO:004354712 | Endometrium | EEC | positive regulation of GTPase activity | 50/2168 | 255/18723 | 1.26e-04 | 1.66e-03 | 50 |
GO:009063012 | Endometrium | EEC | activation of GTPase activity | 23/2168 | 115/18723 | 6.04e-03 | 3.57e-02 | 23 |
GO:004308715 | Esophagus | ESCC | regulation of GTPase activity | 183/8552 | 348/18723 | 5.34e-03 | 2.00e-02 | 183 |
GO:00430875 | Liver | NAFLD | regulation of GTPase activity | 62/1882 | 348/18723 | 5.65e-06 | 2.03e-04 | 62 |
GO:00435474 | Liver | NAFLD | positive regulation of GTPase activity | 45/1882 | 255/18723 | 1.30e-04 | 2.47e-03 | 45 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TBC1D22A | SNV | Missense_Mutation | rs369108625 | c.1000A>G | p.Ile334Val | p.I334V | Q8WUA7 | protein_coding | tolerated(0.13) | benign(0) | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TBC1D22A | SNV | Missense_Mutation | c.1192C>T | p.Arg398Trp | p.R398W | Q8WUA7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A0FV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TBC1D22A | insertion | Frame_Shift_Ins | novel | c.246_247insT | p.Ala83CysfsTer22 | p.A83Cfs*22 | Q8WUA7 | protein_coding | TCGA-BH-A0DS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
TBC1D22A | SNV | Missense_Mutation | rs138576280 | c.1342N>A | p.Gly448Ser | p.G448S | Q8WUA7 | protein_coding | deleterious(0.01) | probably_damaging(0.957) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TBC1D22A | SNV | Missense_Mutation | c.1372N>A | p.Ala458Thr | p.A458T | Q8WUA7 | protein_coding | deleterious(0) | possibly_damaging(0.896) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
TBC1D22A | SNV | Missense_Mutation | novel | c.334N>T | p.Pro112Ser | p.P112S | Q8WUA7 | protein_coding | tolerated(0.74) | benign(0.006) | TCGA-A6-2677-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Ancillary | leucovorin | SD |
TBC1D22A | SNV | Missense_Mutation | c.1372N>A | p.Ala458Thr | p.A458T | Q8WUA7 | protein_coding | deleterious(0) | possibly_damaging(0.896) | TCGA-A6-5660-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | SD | |
TBC1D22A | SNV | Missense_Mutation | rs756141681 | c.796N>A | p.Asp266Asn | p.D266N | Q8WUA7 | protein_coding | deleterious(0.04) | benign(0.015) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TBC1D22A | SNV | Missense_Mutation | rs771756934 | c.935G>A | p.Arg312His | p.R312H | Q8WUA7 | protein_coding | deleterious(0) | probably_damaging(0.929) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TBC1D22A | SNV | Missense_Mutation | c.1496C>T | p.Ala499Val | p.A499V | Q8WUA7 | protein_coding | deleterious(0) | possibly_damaging(0.451) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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