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Gene: SELENOW |
Gene summary for SELENOW |
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Gene information | Species | Human | Gene symbol | SELENOW | Gene ID | 6415 |
Gene name | selenoprotein W | |
Gene Alias | SEPW1 | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | P63302 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6415 | SELENOW | LZE22T | Human | Esophagus | ESCC | 9.25e-35 | 2.14e+00 | 0.068 |
6415 | SELENOW | LZE24D1 | Human | Esophagus | HGIN | 6.21e-05 | 1.72e+00 | 0.054 |
6415 | SELENOW | LZE24T | Human | Esophagus | ESCC | 7.89e-71 | 1.94e+00 | 0.0596 |
6415 | SELENOW | LZE22D3 | Human | Esophagus | HGIN | 1.62e-12 | 1.89e+00 | 0.0653 |
6415 | SELENOW | LZE21T | Human | Esophagus | ESCC | 1.84e-27 | 1.64e+00 | 0.0655 |
6415 | SELENOW | LZE6T | Human | Esophagus | ESCC | 1.11e-52 | 2.13e+00 | 0.0845 |
6415 | SELENOW | HCC1 | Human | Liver | HCC | 1.14e-06 | 3.04e+00 | 0.5336 |
6415 | SELENOW | HCC2 | Human | Liver | HCC | 2.36e-09 | 2.47e+00 | 0.5341 |
6415 | SELENOW | HCC5 | Human | Liver | HCC | 4.25e-03 | 8.62e-01 | 0.4932 |
6415 | SELENOW | S014 | Human | Liver | HCC | 2.73e-86 | 2.89e+00 | 0.2254 |
6415 | SELENOW | S015 | Human | Liver | HCC | 5.18e-80 | 3.75e+00 | 0.2375 |
6415 | SELENOW | S016 | Human | Liver | HCC | 2.50e-79 | 2.84e+00 | 0.2243 |
6415 | SELENOW | S027 | Human | Liver | HCC | 2.17e-42 | 3.39e+00 | 0.2446 |
6415 | SELENOW | S028 | Human | Liver | HCC | 2.70e-76 | 3.73e+00 | 0.2503 |
6415 | SELENOW | S029 | Human | Liver | HCC | 3.34e-73 | 4.03e+00 | 0.2581 |
6415 | SELENOW | TD9 | Human | Lung | IAC | 5.30e-08 | 9.73e-01 | 0.088 |
6415 | SELENOW | RNA-P10T1-P10T1-2 | Human | Lung | AIS | 2.49e-02 | 8.20e-01 | -0.1028 |
6415 | SELENOW | RNA-P10T2-P10T2-1 | Human | Lung | AAH | 7.31e-03 | 6.18e-01 | -0.1271 |
6415 | SELENOW | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 1.30e-05 | 7.68e-01 | -0.1406 |
6415 | SELENOW | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 1.22e-02 | 5.41e-01 | -0.1408 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00988698 | Breast | Precancer | cellular oxidant detoxification | 20/1080 | 101/18723 | 1.07e-06 | 4.18e-05 | 20 |
GO:19907488 | Breast | Precancer | cellular detoxification | 21/1080 | 116/18723 | 2.67e-06 | 8.89e-05 | 21 |
GO:00987548 | Breast | Precancer | detoxification | 24/1080 | 152/18723 | 6.49e-06 | 1.81e-04 | 24 |
GO:00972378 | Breast | Precancer | cellular response to toxic substance | 21/1080 | 124/18723 | 7.98e-06 | 2.17e-04 | 21 |
GO:00096368 | Breast | Precancer | response to toxic substance | 31/1080 | 262/18723 | 1.18e-04 | 2.12e-03 | 31 |
GO:00102693 | Breast | Precancer | response to selenium ion | 4/1080 | 11/18723 | 2.62e-03 | 2.34e-02 | 4 |
GO:000963613 | Breast | IDC | response to toxic substance | 44/1434 | 262/18723 | 6.33e-07 | 3.00e-05 | 44 |
GO:009875413 | Breast | IDC | detoxification | 29/1434 | 152/18723 | 3.97e-06 | 1.43e-04 | 29 |
GO:009886913 | Breast | IDC | cellular oxidant detoxification | 22/1434 | 101/18723 | 6.31e-06 | 1.98e-04 | 22 |
GO:199074813 | Breast | IDC | cellular detoxification | 23/1434 | 116/18723 | 2.02e-05 | 4.92e-04 | 23 |
GO:009723713 | Breast | IDC | cellular response to toxic substance | 24/1434 | 124/18723 | 2.05e-05 | 4.97e-04 | 24 |
GO:00102691 | Breast | IDC | response to selenium ion | 6/1434 | 11/18723 | 6.59e-05 | 1.35e-03 | 6 |
GO:000963623 | Breast | DCIS | response to toxic substance | 42/1390 | 262/18723 | 1.76e-06 | 6.56e-05 | 42 |
GO:009875423 | Breast | DCIS | detoxification | 29/1390 | 152/18723 | 2.15e-06 | 7.79e-05 | 29 |
GO:009886923 | Breast | DCIS | cellular oxidant detoxification | 22/1390 | 101/18723 | 3.82e-06 | 1.16e-04 | 22 |
GO:199074823 | Breast | DCIS | cellular detoxification | 23/1390 | 116/18723 | 1.22e-05 | 3.12e-04 | 23 |
GO:009723723 | Breast | DCIS | cellular response to toxic substance | 24/1390 | 124/18723 | 1.22e-05 | 3.12e-04 | 24 |
GO:00102692 | Breast | DCIS | response to selenium ion | 6/1390 | 11/18723 | 5.53e-05 | 1.12e-03 | 6 |
GO:00988699 | Cervix | CC | cellular oxidant detoxification | 30/2311 | 101/18723 | 2.72e-06 | 7.93e-05 | 30 |
GO:19907489 | Cervix | CC | cellular detoxification | 30/2311 | 116/18723 | 5.34e-05 | 7.94e-04 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SELENOW | SNV | Missense_Mutation | novel | c.210A>C | p.Glu70Asp | p.E70D | P63302 | protein_coding | tolerated(0.48) | possibly_damaging(0.787) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SELENOW | SNV | Missense_Mutation | c.235G>A | p.Ala79Thr | p.A79T | P63302 | protein_coding | tolerated(0.16) | possibly_damaging(0.893) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
SELENOW | SNV | Missense_Mutation | novel | c.212N>T | p.Ser71Ile | p.S71I | P63302 | protein_coding | tolerated(0.06) | benign(0.006) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SELENOW | SNV | Missense_Mutation | novel | c.72G>T | p.Lys24Asn | p.K24N | P63302 | protein_coding | tolerated(0.11) | possibly_damaging(0.463) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SELENOW | SNV | Missense_Mutation | novel | c.251N>C | p.Leu84Ser | p.L84S | P63302 | protein_coding | deleterious(0) | benign(0.146) | TCGA-EO-A3AU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SELENOW | SNV | Missense_Mutation | novel | c.157N>T | p.Ala53Ser | p.A53S | P63302 | protein_coding | tolerated(0.56) | benign(0.303) | TCGA-VQ-A8DT-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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