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Gene: SELENBP1 |
Gene summary for SELENBP1 |
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Gene information | Species | Human | Gene symbol | SELENBP1 | Gene ID | 8991 |
Gene name | selenium binding protein 1 | |
Gene Alias | EHMTO | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q13228 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8991 | SELENBP1 | RNA-P17T-P17T-8 | Human | Lung | IAC | 2.62e-05 | -7.13e-01 | 0.3329 |
8991 | SELENBP1 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 2.14e-15 | -4.06e-01 | -0.2116 |
8991 | SELENBP1 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 1.05e-04 | -4.54e-01 | -0.1941 |
8991 | SELENBP1 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 2.21e-07 | -1.86e-01 | -0.2107 |
8991 | SELENBP1 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 4.45e-11 | -2.61e-01 | -0.2119 |
8991 | SELENBP1 | RNA-P3T-P3T-1 | Human | Lung | IAC | 2.08e-06 | -1.09e+00 | 0.1829 |
8991 | SELENBP1 | RNA-P3T-P3T-2 | Human | Lung | IAC | 3.68e-10 | -1.03e+00 | 0.1835 |
8991 | SELENBP1 | RNA-P3T-P3T-4 | Human | Lung | IAC | 2.95e-09 | -9.86e-01 | 0.1859 |
8991 | SELENBP1 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 4.66e-18 | -8.42e-01 | -0.0166 |
8991 | SELENBP1 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 7.38e-21 | -6.74e-01 | -0.0132 |
8991 | SELENBP1 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 3.01e-23 | -6.89e-01 | -0.013 |
8991 | SELENBP1 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 1.73e-19 | -7.54e-01 | -0.0121 |
8991 | SELENBP1 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 5.05e-06 | -5.74e-01 | -0.0961 |
8991 | SELENBP1 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 9.74e-06 | -5.74e-01 | -0.0876 |
8991 | SELENBP1 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 7.99e-03 | -5.92e-01 | -0.0822 |
8991 | SELENBP1 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 1.75e-03 | -5.50e-01 | -0.0809 |
8991 | SELENBP1 | C43 | Human | Oral cavity | OSCC | 2.04e-02 | 1.74e-02 | 0.1704 |
8991 | SELENBP1 | C46 | Human | Oral cavity | OSCC | 3.01e-31 | 8.35e-01 | 0.1673 |
8991 | SELENBP1 | LN46 | Human | Oral cavity | OSCC | 8.68e-09 | 5.31e-01 | 0.1666 |
8991 | SELENBP1 | NEOLP-2 | Human | Oral cavity | NEOLP | 2.39e-05 | 1.82e-01 | -0.0196 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00920 | Colorectum | AD | Sulfur metabolism | 8/2092 | 10/8465 | 3.78e-04 | 2.82e-03 | 1.80e-03 | 8 |
hsa009201 | Colorectum | AD | Sulfur metabolism | 8/2092 | 10/8465 | 3.78e-04 | 2.82e-03 | 1.80e-03 | 8 |
hsa009202 | Colorectum | SER | Sulfur metabolism | 8/1580 | 10/8465 | 4.56e-05 | 5.22e-04 | 3.79e-04 | 8 |
hsa009203 | Colorectum | SER | Sulfur metabolism | 8/1580 | 10/8465 | 4.56e-05 | 5.22e-04 | 3.79e-04 | 8 |
hsa009206 | Colorectum | FAP | Sulfur metabolism | 6/1404 | 10/8465 | 2.36e-03 | 1.13e-02 | 6.85e-03 | 6 |
hsa009207 | Colorectum | FAP | Sulfur metabolism | 6/1404 | 10/8465 | 2.36e-03 | 1.13e-02 | 6.85e-03 | 6 |
hsa009208 | Colorectum | CRC | Sulfur metabolism | 5/1091 | 10/8465 | 5.07e-03 | 2.72e-02 | 1.84e-02 | 5 |
hsa009209 | Colorectum | CRC | Sulfur metabolism | 5/1091 | 10/8465 | 5.07e-03 | 2.72e-02 | 1.84e-02 | 5 |
hsa0092010 | Esophagus | ESCC | Sulfur metabolism | 9/4205 | 10/8465 | 1.01e-02 | 2.38e-02 | 1.22e-02 | 9 |
hsa0092011 | Esophagus | ESCC | Sulfur metabolism | 9/4205 | 10/8465 | 1.01e-02 | 2.38e-02 | 1.22e-02 | 9 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SELENBP1 | SNV | Missense_Mutation | rs756477901 | c.929N>A | p.Cys310Tyr | p.C310Y | Q13228 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-B6-A400-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SELENBP1 | SNV | Missense_Mutation | novel | c.15N>C | p.Trp5Cys | p.W5C | Q13228 | protein_coding | deleterious_low_confidence(0) | benign(0.028) | TCGA-BH-A0RX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
SELENBP1 | SNV | Missense_Mutation | novel | c.733G>A | p.Glu245Lys | p.E245K | Q13228 | protein_coding | deleterious(0) | possibly_damaging(0.615) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
SELENBP1 | SNV | Missense_Mutation | rs765918794 | c.953G>A | p.Arg318His | p.R318H | Q13228 | protein_coding | tolerated(0.43) | benign(0.019) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SELENBP1 | SNV | Missense_Mutation | c.1500N>T | p.Glu500Asp | p.E500D | Q13228 | protein_coding | tolerated(0.06) | probably_damaging(0.997) | TCGA-EK-A2RN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SELENBP1 | SNV | Missense_Mutation | c.1097N>C | p.Phe366Ser | p.F366S | Q13228 | protein_coding | deleterious(0.02) | possibly_damaging(0.908) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SELENBP1 | SNV | Missense_Mutation | novel | c.1151N>T | p.Arg384Ile | p.R384I | Q13228 | protein_coding | deleterious(0.03) | possibly_damaging(0.642) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
SELENBP1 | SNV | Missense_Mutation | rs201828270 | c.710G>A | p.Arg237Gln | p.R237Q | Q13228 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SELENBP1 | SNV | Missense_Mutation | novel | c.837G>T | p.Glu279Asp | p.E279D | Q13228 | protein_coding | tolerated(0.13) | benign(0.364) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SELENBP1 | SNV | Missense_Mutation | novel | c.941N>T | p.Ser314Phe | p.S314F | Q13228 | protein_coding | deleterious(0) | possibly_damaging(0.851) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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