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Gene: RPL32 |
Gene summary for RPL32 |
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Gene information | Species | Human | Gene symbol | RPL32 | Gene ID | 6161 |
Gene name | ribosomal protein L32 | |
Gene Alias | L32 | |
Cytomap | 3p25.2 | |
Gene Type | protein-coding | GO ID | GO:0002181 | UniProtAcc | A0A024R2G7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6161 | RPL32 | P5T-E | Human | Esophagus | ESCC | 3.08e-119 | 5.57e+00 | 0.1327 |
6161 | RPL32 | P8T-E | Human | Esophagus | ESCC | 5.28e-77 | 3.07e+00 | 0.0889 |
6161 | RPL32 | P9T-E | Human | Esophagus | ESCC | 5.93e-70 | 4.03e+00 | 0.1131 |
6161 | RPL32 | P10T-E | Human | Esophagus | ESCC | 8.44e-104 | 4.29e+00 | 0.116 |
6161 | RPL32 | P11T-E | Human | Esophagus | ESCC | 2.69e-46 | 3.00e+00 | 0.1426 |
6161 | RPL32 | P12T-E | Human | Esophagus | ESCC | 8.07e-95 | 3.52e+00 | 0.1122 |
6161 | RPL32 | P15T-E | Human | Esophagus | ESCC | 2.51e-82 | 3.59e+00 | 0.1149 |
6161 | RPL32 | P16T-E | Human | Esophagus | ESCC | 4.07e-98 | 3.73e+00 | 0.1153 |
6161 | RPL32 | P17T-E | Human | Esophagus | ESCC | 1.51e-37 | 3.66e+00 | 0.1278 |
6161 | RPL32 | P19T-E | Human | Esophagus | ESCC | 1.06e-31 | 3.81e+00 | 0.1662 |
6161 | RPL32 | P20T-E | Human | Esophagus | ESCC | 2.84e-99 | 4.14e+00 | 0.1124 |
6161 | RPL32 | P21T-E | Human | Esophagus | ESCC | 1.62e-126 | 4.26e+00 | 0.1617 |
6161 | RPL32 | P22T-E | Human | Esophagus | ESCC | 3.99e-123 | 3.64e+00 | 0.1236 |
6161 | RPL32 | P23T-E | Human | Esophagus | ESCC | 1.93e-71 | 4.90e+00 | 0.108 |
6161 | RPL32 | P24T-E | Human | Esophagus | ESCC | 6.12e-86 | 3.88e+00 | 0.1287 |
6161 | RPL32 | P26T-E | Human | Esophagus | ESCC | 6.55e-134 | 4.61e+00 | 0.1276 |
6161 | RPL32 | P27T-E | Human | Esophagus | ESCC | 7.20e-114 | 3.77e+00 | 0.1055 |
6161 | RPL32 | P28T-E | Human | Esophagus | ESCC | 8.67e-98 | 4.49e+00 | 0.1149 |
6161 | RPL32 | P30T-E | Human | Esophagus | ESCC | 1.12e-75 | 4.62e+00 | 0.137 |
6161 | RPL32 | P31T-E | Human | Esophagus | ESCC | 4.80e-98 | 3.53e+00 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00021819 | Breast | Precancer | cytoplasmic translation | 80/1080 | 148/18723 | 1.59e-59 | 8.54e-56 | 80 |
GO:000218114 | Breast | IDC | cytoplasmic translation | 82/1434 | 148/18723 | 2.60e-52 | 1.48e-48 | 82 |
GO:000218124 | Breast | DCIS | cytoplasmic translation | 82/1390 | 148/18723 | 2.21e-53 | 1.25e-49 | 82 |
GO:000218110 | Cervix | CC | cytoplasmic translation | 96/2311 | 148/18723 | 4.87e-51 | 2.91e-47 | 96 |
GO:000218115 | Cervix | HSIL_HPV | cytoplasmic translation | 86/737 | 148/18723 | 3.97e-82 | 1.91e-78 | 86 |
GO:0002181 | Colorectum | AD | cytoplasmic translation | 109/3918 | 148/18723 | 3.40e-43 | 2.13e-39 | 109 |
GO:00021811 | Colorectum | SER | cytoplasmic translation | 102/2897 | 148/18723 | 1.38e-48 | 8.49e-45 | 102 |
GO:00021812 | Colorectum | MSS | cytoplasmic translation | 108/3467 | 148/18723 | 1.78e-47 | 1.11e-43 | 108 |
GO:00021813 | Colorectum | MSI-H | cytoplasmic translation | 100/1319 | 148/18723 | 1.50e-79 | 8.31e-76 | 100 |
GO:00021815 | Colorectum | CRC | cytoplasmic translation | 70/2078 | 148/18723 | 1.53e-28 | 9.16e-25 | 70 |
GO:000218116 | Endometrium | AEH | cytoplasmic translation | 104/2100 | 148/18723 | 1.01e-64 | 6.07e-61 | 104 |
GO:000218117 | Endometrium | EEC | cytoplasmic translation | 104/2168 | 148/18723 | 2.53e-63 | 1.52e-59 | 104 |
GO:000218127 | Esophagus | HGIN | cytoplasmic translation | 108/2587 | 148/18723 | 1.70e-60 | 1.02e-56 | 108 |
GO:0002181111 | Esophagus | ESCC | cytoplasmic translation | 135/8552 | 148/18723 | 4.17e-32 | 2.65e-29 | 135 |
GO:00021817 | Liver | NAFLD | cytoplasmic translation | 93/1882 | 148/18723 | 1.44e-55 | 8.41e-52 | 93 |
GO:000218112 | Liver | Cirrhotic | cytoplasmic translation | 120/4634 | 148/18723 | 2.95e-47 | 1.85e-43 | 120 |
GO:000218122 | Liver | HCC | cytoplasmic translation | 132/7958 | 148/18723 | 9.09e-33 | 5.76e-30 | 132 |
GO:000218132 | Liver | Cyst | cytoplasmic translation | 70/496 | 148/18723 | 9.01e-71 | 3.85e-67 | 70 |
GO:00021818 | Lung | IAC | cytoplasmic translation | 85/2061 | 148/18723 | 3.11e-43 | 1.85e-39 | 85 |
GO:000218113 | Lung | AIS | cytoplasmic translation | 85/1849 | 148/18723 | 5.48e-47 | 3.19e-43 | 85 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301018 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0517118 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0301019 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0517119 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0301024 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0517124 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301034 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0517134 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301044 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517144 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0301054 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517154 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0517120 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa0301020 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa05171110 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa03010110 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa0301025 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517125 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
hsa0301035 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517135 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPL32 | SNV | Missense_Mutation | c.58N>C | p.Phe20Leu | p.F20L | P62910 | protein_coding | deleterious(0.02) | possibly_damaging(0.651) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
RPL32 | SNV | Missense_Mutation | c.181N>A | p.Gly61Arg | p.G61R | P62910 | protein_coding | tolerated(0.14) | benign(0.219) | TCGA-C5-A8XK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
RPL32 | SNV | Missense_Mutation | rs200198457 | c.275N>G | p.Asn92Ser | p.N92S | P62910 | protein_coding | tolerated(0.08) | benign(0.108) | TCGA-AA-3869-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD |
RPL32 | SNV | Missense_Mutation | rs773469396 | c.80N>A | p.Arg27Gln | p.R27Q | P62910 | protein_coding | tolerated(0.16) | benign(0.068) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RPL32 | SNV | Missense_Mutation | novel | c.206T>A | p.Met69Lys | p.M69K | P62910 | protein_coding | deleterious(0.01) | benign(0.054) | TCGA-AA-A02J-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
RPL32 | SNV | Missense_Mutation | c.7N>A | p.Ala3Thr | p.A3T | P62910 | protein_coding | tolerated(0.15) | benign(0.01) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
RPL32 | SNV | Missense_Mutation | novel | c.244N>A | p.Val82Ile | p.V82I | P62910 | protein_coding | tolerated(0.27) | benign(0.027) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPL32 | SNV | Missense_Mutation | c.193N>G | p.Lys65Glu | p.K65E | P62910 | protein_coding | deleterious(0.04) | benign(0.042) | TCGA-66-2791-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
RPL32 | SNV | Missense_Mutation | novel | c.250G>C | p.Glu84Gln | p.E84Q | P62910 | protein_coding | deleterious(0.01) | possibly_damaging(0.84) | TCGA-CV-A6K2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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