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Gene: PPP4R2 |
Gene summary for PPP4R2 |
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Gene information | Species | Human | Gene symbol | PPP4R2 | Gene ID | 151987 |
Gene name | protein phosphatase 4 regulatory subunit 2 | |
Gene Alias | PP4R2 | |
Cytomap | 3p13 | |
Gene Type | protein-coding | GO ID | GO:0000018 | UniProtAcc | Q9NY27 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
151987 | PPP4R2 | C51 | Human | Oral cavity | OSCC | 4.96e-03 | 4.58e-01 | 0.2674 |
151987 | PPP4R2 | C57 | Human | Oral cavity | OSCC | 4.58e-26 | 8.82e-01 | 0.1679 |
151987 | PPP4R2 | C06 | Human | Oral cavity | OSCC | 5.10e-05 | 1.04e+00 | 0.2699 |
151987 | PPP4R2 | C08 | Human | Oral cavity | OSCC | 9.23e-06 | 2.68e-01 | 0.1919 |
151987 | PPP4R2 | C09 | Human | Oral cavity | OSCC | 1.16e-10 | 5.07e-01 | 0.1431 |
151987 | PPP4R2 | LN22 | Human | Oral cavity | OSCC | 3.69e-09 | 9.93e-01 | 0.1733 |
151987 | PPP4R2 | LN46 | Human | Oral cavity | OSCC | 1.18e-09 | 5.49e-01 | 0.1666 |
151987 | PPP4R2 | LP15 | Human | Oral cavity | LP | 2.53e-03 | 8.04e-01 | 0.2174 |
151987 | PPP4R2 | EOLP-1 | Human | Oral cavity | EOLP | 1.36e-04 | 2.44e-01 | -0.0202 |
151987 | PPP4R2 | SYSMH1 | Human | Oral cavity | OSCC | 1.78e-03 | 1.31e-01 | 0.1127 |
151987 | PPP4R2 | SYSMH2 | Human | Oral cavity | OSCC | 1.75e-06 | 3.03e-01 | 0.2326 |
151987 | PPP4R2 | SYSMH3 | Human | Oral cavity | OSCC | 9.21e-26 | 6.67e-01 | 0.2442 |
151987 | PPP4R2 | P4_S8_cSCC | Human | Skin | cSCC | 1.43e-07 | 1.13e-01 | -0.3095 |
151987 | PPP4R2 | P5_S10_cSCC | Human | Skin | cSCC | 5.84e-03 | 6.93e-02 | -0.299 |
151987 | PPP4R2 | P1_cSCC | Human | Skin | cSCC | 4.35e-17 | 6.83e-01 | 0.0292 |
151987 | PPP4R2 | P2_cSCC | Human | Skin | cSCC | 1.18e-07 | 4.15e-01 | -0.024 |
151987 | PPP4R2 | P4_cSCC | Human | Skin | cSCC | 4.10e-13 | 5.61e-01 | -0.00290000000000005 |
151987 | PPP4R2 | P10_cSCC | Human | Skin | cSCC | 3.31e-20 | 7.75e-01 | 0.1017 |
151987 | PPP4R2 | cSCC_p7 | Human | Skin | cSCC | 1.71e-02 | -1.43e-01 | -0.2332 |
151987 | PPP4R2 | cSCC_p8 | Human | Skin | cSCC | 7.90e-03 | 4.51e-02 | -0.1971 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:0051052 | Colorectum | AD | regulation of DNA metabolic process | 116/3918 | 359/18723 | 2.47e-07 | 1.00e-05 | 116 |
GO:0016311 | Colorectum | AD | dephosphorylation | 123/3918 | 417/18723 | 1.84e-05 | 3.82e-04 | 123 |
GO:0006470 | Colorectum | AD | protein dephosphorylation | 88/3918 | 281/18723 | 2.56e-05 | 4.89e-04 | 88 |
GO:2001020 | Colorectum | AD | regulation of response to DNA damage stimulus | 71/3918 | 219/18723 | 4.38e-05 | 7.65e-04 | 71 |
GO:0006282 | Colorectum | AD | regulation of DNA repair | 42/3918 | 130/18723 | 1.57e-03 | 1.32e-02 | 42 |
GO:00083801 | Colorectum | SER | RNA splicing | 123/2897 | 434/18723 | 3.84e-12 | 8.41e-10 | 123 |
GO:00510521 | Colorectum | SER | regulation of DNA metabolic process | 83/2897 | 359/18723 | 8.03e-05 | 1.77e-03 | 83 |
GO:00064701 | Colorectum | SER | protein dephosphorylation | 65/2897 | 281/18723 | 4.44e-04 | 6.51e-03 | 65 |
GO:00163111 | Colorectum | SER | dephosphorylation | 86/2897 | 417/18723 | 2.73e-03 | 2.46e-02 | 86 |
GO:20010201 | Colorectum | SER | regulation of response to DNA damage stimulus | 49/2897 | 219/18723 | 4.24e-03 | 3.45e-02 | 49 |
GO:00083802 | Colorectum | MSS | RNA splicing | 159/3467 | 434/18723 | 1.75e-19 | 1.22e-16 | 159 |
GO:00510522 | Colorectum | MSS | regulation of DNA metabolic process | 108/3467 | 359/18723 | 5.86e-08 | 3.10e-06 | 108 |
GO:20010202 | Colorectum | MSS | regulation of response to DNA damage stimulus | 64/3467 | 219/18723 | 7.20e-05 | 1.21e-03 | 64 |
GO:00064702 | Colorectum | MSS | protein dephosphorylation | 73/3467 | 281/18723 | 1.15e-03 | 1.12e-02 | 73 |
GO:00062821 | Colorectum | MSS | regulation of DNA repair | 38/3467 | 130/18723 | 1.93e-03 | 1.67e-02 | 38 |
GO:00163112 | Colorectum | MSS | dephosphorylation | 101/3467 | 417/18723 | 1.98e-03 | 1.70e-02 | 101 |
GO:0006302 | Colorectum | MSS | double-strand break repair | 64/3467 | 251/18723 | 3.58e-03 | 2.65e-02 | 64 |
GO:00083804 | Colorectum | FAP | RNA splicing | 108/2622 | 434/18723 | 7.90e-10 | 1.86e-07 | 108 |
GO:00163113 | Colorectum | FAP | dephosphorylation | 95/2622 | 417/18723 | 7.07e-07 | 3.32e-05 | 95 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPP4R2 | SNV | Missense_Mutation | c.445N>G | p.Arg149Gly | p.R149G | Q9NY27 | protein_coding | deleterious(0.02) | probably_damaging(0.974) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PPP4R2 | SNV | Missense_Mutation | c.1207N>A | p.Asp403Asn | p.D403N | Q9NY27 | protein_coding | tolerated(0.77) | benign(0) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PPP4R2 | SNV | Missense_Mutation | novel | c.904N>C | p.Glu302Gln | p.E302Q | Q9NY27 | protein_coding | deleterious(0.05) | benign(0.029) | TCGA-AO-A0J4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
PPP4R2 | SNV | Missense_Mutation | c.203N>C | p.Arg68Thr | p.R68T | Q9NY27 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BH-A18K-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
PPP4R2 | SNV | Missense_Mutation | c.958N>G | p.Pro320Ala | p.P320A | Q9NY27 | protein_coding | tolerated(0.18) | benign(0.001) | TCGA-BH-A18V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PPP4R2 | insertion | Nonsense_Mutation | novel | c.918_919insTCACTGTAAAT | p.Glu307SerfsTer3 | p.E307Sfs*3 | Q9NY27 | protein_coding | TCGA-AN-A0FY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PPP4R2 | insertion | Frame_Shift_Ins | novel | c.918_919insTCACT | p.Glu307SerfsTer9 | p.E307Sfs*9 | Q9NY27 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PPP4R2 | insertion | Frame_Shift_Ins | novel | c.919_920insT | p.Glu307ValfsTer24 | p.E307Vfs*24 | Q9NY27 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PPP4R2 | SNV | Missense_Mutation | novel | c.940A>G | p.Thr314Ala | p.T314A | Q9NY27 | protein_coding | deleterious(0.04) | probably_damaging(0.956) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
PPP4R2 | SNV | Missense_Mutation | c.496N>C | p.Ser166Pro | p.S166P | Q9NY27 | protein_coding | deleterious(0.04) | benign(0.023) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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