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Gene: NSFL1C |
Gene summary for NSFL1C |
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Gene information | Species | Human | Gene symbol | NSFL1C | Gene ID | 55968 |
Gene name | NSFL1 cofactor | |
Gene Alias | P47 | |
Cytomap | 20p13 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | Q53FE8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55968 | NSFL1C | P5_S10_cSCC | Human | Skin | cSCC | 4.33e-11 | 2.32e-01 | -0.299 |
55968 | NSFL1C | P1_cSCC | Human | Skin | cSCC | 8.08e-46 | 1.38e+00 | 0.0292 |
55968 | NSFL1C | P2_cSCC | Human | Skin | cSCC | 4.60e-29 | 7.77e-01 | -0.024 |
55968 | NSFL1C | P4_cSCC | Human | Skin | cSCC | 6.86e-66 | 1.27e+00 | -0.00290000000000005 |
55968 | NSFL1C | P10_cSCC | Human | Skin | cSCC | 1.83e-35 | 1.05e+00 | 0.1017 |
55968 | NSFL1C | cSCC_p8 | Human | Skin | cSCC | 3.46e-13 | 1.33e-01 | -0.1971 |
55968 | NSFL1C | cSCC_p9 | Human | Skin | cSCC | 1.21e-03 | 1.17e-01 | -0.1991 |
55968 | NSFL1C | male-WTA | Human | Thyroid | PTC | 2.20e-31 | 2.46e-01 | 0.1037 |
55968 | NSFL1C | PTC01 | Human | Thyroid | PTC | 3.84e-16 | 2.81e-01 | 0.1899 |
55968 | NSFL1C | PTC03 | Human | Thyroid | PTC | 1.54e-02 | 4.97e-02 | 0.1784 |
55968 | NSFL1C | PTC04 | Human | Thyroid | PTC | 3.28e-11 | 1.49e-01 | 0.1927 |
55968 | NSFL1C | PTC05 | Human | Thyroid | PTC | 3.57e-14 | 6.19e-01 | 0.2065 |
55968 | NSFL1C | PTC06 | Human | Thyroid | PTC | 5.26e-30 | 6.79e-01 | 0.2057 |
55968 | NSFL1C | PTC07 | Human | Thyroid | PTC | 3.73e-35 | 4.90e-01 | 0.2044 |
55968 | NSFL1C | ATC09 | Human | Thyroid | ATC | 1.63e-10 | 5.72e-01 | 0.2871 |
55968 | NSFL1C | ATC11 | Human | Thyroid | ATC | 6.90e-04 | 7.16e-01 | 0.3386 |
55968 | NSFL1C | ATC12 | Human | Thyroid | ATC | 6.13e-22 | 5.10e-01 | 0.34 |
55968 | NSFL1C | ATC13 | Human | Thyroid | ATC | 4.89e-28 | 4.38e-01 | 0.34 |
55968 | NSFL1C | ATC1 | Human | Thyroid | ATC | 6.89e-12 | 6.58e-01 | 0.2878 |
55968 | NSFL1C | ATC2 | Human | Thyroid | ATC | 1.06e-14 | 8.86e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498 | Colorectum | AD | proteasomal protein catabolic process | 174/3918 | 490/18723 | 3.18e-14 | 7.66e-12 | 174 |
GO:0043161 | Colorectum | AD | proteasome-mediated ubiquitin-dependent protein catabolic process | 141/3918 | 412/18723 | 1.77e-10 | 1.68e-08 | 141 |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
GO:0016236 | Colorectum | AD | macroautophagy | 103/3918 | 291/18723 | 6.76e-09 | 4.15e-07 | 103 |
GO:0007163 | Colorectum | AD | establishment or maintenance of cell polarity | 77/3918 | 218/18723 | 5.72e-07 | 2.08e-05 | 77 |
GO:0030010 | Colorectum | AD | establishment of cell polarity | 50/3918 | 143/18723 | 6.90e-05 | 1.11e-03 | 50 |
GO:0071709 | Colorectum | AD | membrane assembly | 22/3918 | 50/18723 | 2.00e-04 | 2.66e-03 | 22 |
GO:0071539 | Colorectum | AD | protein localization to centrosome | 16/3918 | 33/18723 | 3.86e-04 | 4.41e-03 | 16 |
GO:1902850 | Colorectum | AD | microtubule cytoskeleton organization involved in mitosis | 48/3918 | 147/18723 | 5.87e-04 | 6.21e-03 | 48 |
GO:1905508 | Colorectum | AD | protein localization to microtubule organizing center | 16/3918 | 35/18723 | 8.76e-04 | 8.51e-03 | 16 |
GO:0044091 | Colorectum | AD | membrane biogenesis | 22/3918 | 55/18723 | 9.88e-04 | 9.28e-03 | 22 |
GO:1903828 | Colorectum | AD | negative regulation of cellular protein localization | 39/3918 | 117/18723 | 1.18e-03 | 1.06e-02 | 39 |
GO:0007033 | Colorectum | AD | vacuole organization | 53/3918 | 180/18723 | 4.18e-03 | 2.89e-02 | 53 |
GO:0045787 | Colorectum | AD | positive regulation of cell cycle | 85/3918 | 313/18723 | 4.76e-03 | 3.22e-02 | 85 |
GO:0140014 | Colorectum | AD | mitotic nuclear division | 78/3918 | 287/18723 | 6.48e-03 | 4.05e-02 | 78 |
GO:00104981 | Colorectum | SER | proteasomal protein catabolic process | 132/2897 | 490/18723 | 3.08e-11 | 5.55e-09 | 132 |
GO:00431611 | Colorectum | SER | proteasome-mediated ubiquitin-dependent protein catabolic process | 105/2897 | 412/18723 | 7.48e-08 | 4.70e-06 | 105 |
GO:00516561 | Colorectum | SER | establishment of organelle localization | 100/2897 | 390/18723 | 1.11e-07 | 6.79e-06 | 100 |
GO:00162361 | Colorectum | SER | macroautophagy | 79/2897 | 291/18723 | 1.97e-07 | 1.10e-05 | 79 |
GO:00071631 | Colorectum | SER | establishment or maintenance of cell polarity | 60/2897 | 218/18723 | 3.45e-06 | 1.33e-04 | 60 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04141 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa041411 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa041412 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa041413 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa041414 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
hsa041415 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
hsa041418 | Colorectum | FAP | Protein processing in endoplasmic reticulum | 50/1404 | 174/8465 | 3.64e-05 | 3.68e-04 | 2.24e-04 | 50 |
hsa041419 | Colorectum | FAP | Protein processing in endoplasmic reticulum | 50/1404 | 174/8465 | 3.64e-05 | 3.68e-04 | 2.24e-04 | 50 |
hsa04141211 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa04141310 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa0414114 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
hsa0414115 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
hsa0414122 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0414132 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0414130 | Oral cavity | OSCC | Protein processing in endoplasmic reticulum | 143/3704 | 174/8465 | 6.82e-26 | 2.28e-23 | 1.16e-23 | 143 |
hsa04141113 | Oral cavity | OSCC | Protein processing in endoplasmic reticulum | 143/3704 | 174/8465 | 6.82e-26 | 2.28e-23 | 1.16e-23 | 143 |
hsa04141210 | Oral cavity | LP | Protein processing in endoplasmic reticulum | 113/2418 | 174/8465 | 8.74e-24 | 5.82e-22 | 3.76e-22 | 113 |
hsa0414138 | Oral cavity | LP | Protein processing in endoplasmic reticulum | 113/2418 | 174/8465 | 8.74e-24 | 5.82e-22 | 3.76e-22 | 113 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NSFL1C | SNV | Missense_Mutation | c.316N>G | p.Gln106Glu | p.Q106E | Q9UNZ2 | protein_coding | tolerated(0.42) | benign(0.263) | TCGA-A2-A25E-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD | |
NSFL1C | SNV | Missense_Mutation | c.488C>T | p.Pro163Leu | p.P163L | Q9UNZ2 | protein_coding | tolerated(0.71) | possibly_damaging(0.491) | TCGA-A7-A0DA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
NSFL1C | SNV | Missense_Mutation | c.179C>T | p.Ser60Leu | p.S60L | Q9UNZ2 | protein_coding | tolerated(0.28) | benign(0.269) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NSFL1C | SNV | Missense_Mutation | novel | c.308N>T | p.Arg103Ile | p.R103I | Q9UNZ2 | protein_coding | tolerated(0.17) | possibly_damaging(0.857) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NSFL1C | SNV | Missense_Mutation | novel | c.650N>A | p.Arg217Lys | p.R217K | Q9UNZ2 | protein_coding | tolerated(0.33) | benign(0.065) | TCGA-EW-A3E8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | SD |
NSFL1C | insertion | Frame_Shift_Ins | novel | c.575_576insTGCCAGCAGAGCTTCGGAGGCTAGCTCA | p.Phe193AlafsTer14 | p.F193Afs*14 | Q9UNZ2 | protein_coding | TCGA-B6-A0IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
NSFL1C | SNV | Missense_Mutation | novel | c.388N>C | p.Glu130Gln | p.E130Q | Q9UNZ2 | protein_coding | deleterious(0.01) | possibly_damaging(0.828) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
NSFL1C | SNV | Missense_Mutation | c.907N>T | p.Arg303Trp | p.R303W | Q9UNZ2 | protein_coding | deleterious(0.03) | probably_damaging(0.978) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NSFL1C | SNV | Missense_Mutation | rs756406410 | c.161C>T | p.Ser54Leu | p.S54L | Q9UNZ2 | protein_coding | tolerated(0.15) | benign(0.07) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NSFL1C | SNV | Missense_Mutation | rs756406410 | c.161N>T | p.Ser54Leu | p.S54L | Q9UNZ2 | protein_coding | tolerated(0.15) | benign(0.07) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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