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Gene: NR4A2 |
Gene summary for NR4A2 |
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Gene information | Species | Human | Gene symbol | NR4A2 | Gene ID | 4929 |
Gene name | nuclear receptor subfamily 4 group A member 2 | |
Gene Alias | HZF-3 | |
Cytomap | 2q24.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | F1D8N6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4929 | NR4A2 | GSM5353226_PA_PR5196-2_Pool_1_2_3_S54_L002 | Human | Prostate | Tumor | 9.72e-04 | 8.56e-01 | 0.159 |
4929 | NR4A2 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 3.62e-03 | 5.00e-01 | 0.1602 |
4929 | NR4A2 | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 3.14e-02 | 3.67e-01 | 0.1575 |
4929 | NR4A2 | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 3.13e-02 | 3.19e-01 | 0.1545 |
4929 | NR4A2 | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 5.23e-05 | 4.78e-01 | 0.1569 |
4929 | NR4A2 | P1_S1_AK | Human | Skin | AK | 3.62e-03 | -3.63e-01 | -0.3399 |
4929 | NR4A2 | P2_S3_AK | Human | Skin | AK | 2.03e-04 | -3.83e-01 | -0.3287 |
4929 | NR4A2 | P2_S4_SCCIS | Human | Skin | SCCIS | 5.56e-03 | -4.29e-01 | -0.3043 |
4929 | NR4A2 | P4_S8_cSCC | Human | Skin | cSCC | 6.86e-03 | -2.33e-03 | -0.3095 |
4929 | NR4A2 | P5_S10_cSCC | Human | Skin | cSCC | 6.14e-09 | -3.82e-01 | -0.299 |
4929 | NR4A2 | cSCC_p1 | Human | Skin | cSCC | 7.61e-03 | 1.07e-01 | -0.1916 |
4929 | NR4A2 | cSCC_p11 | Human | Skin | cSCC | 4.17e-03 | -4.60e-02 | -0.2102 |
4929 | NR4A2 | cSCC_p3 | Human | Skin | cSCC | 1.01e-05 | -4.20e-01 | -0.2085 |
4929 | NR4A2 | cSCC_p4 | Human | Skin | cSCC | 2.09e-03 | -2.12e-01 | -0.2022 |
4929 | NR4A2 | cSCC_p6 | Human | Skin | cSCC | 1.59e-06 | -3.40e-01 | -0.1989 |
4929 | NR4A2 | cSCC_p8 | Human | Skin | cSCC | 7.22e-05 | -5.47e-02 | -0.1971 |
4929 | NR4A2 | cSCC_p9 | Human | Skin | cSCC | 3.20e-07 | -4.14e-02 | -0.1991 |
4929 | NR4A2 | male-WTA | Human | Thyroid | PTC | 2.69e-06 | -2.46e-01 | 0.1037 |
4929 | NR4A2 | PTC01 | Human | Thyroid | PTC | 1.54e-02 | 1.34e-02 | 0.1899 |
4929 | NR4A2 | PTC04 | Human | Thyroid | PTC | 2.19e-04 | -1.66e-01 | 0.1927 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:20012339 | Breast | Precancer | regulation of apoptotic signaling pathway | 65/1080 | 356/18723 | 7.70e-17 | 3.17e-14 | 65 |
GO:00069799 | Breast | Precancer | response to oxidative stress | 70/1080 | 446/18723 | 1.59e-14 | 4.26e-12 | 70 |
GO:00362939 | Breast | Precancer | response to decreased oxygen levels | 53/1080 | 322/18723 | 4.09e-12 | 6.84e-10 | 53 |
GO:00016669 | Breast | Precancer | response to hypoxia | 51/1080 | 307/18723 | 7.33e-12 | 1.11e-09 | 51 |
GO:00704829 | Breast | Precancer | response to oxygen levels | 55/1080 | 347/18723 | 7.47e-12 | 1.11e-09 | 55 |
GO:00621979 | Breast | Precancer | cellular response to chemical stress | 51/1080 | 337/18723 | 2.40e-10 | 2.34e-08 | 51 |
GO:20012349 | Breast | Precancer | negative regulation of apoptotic signaling pathway | 39/1080 | 224/18723 | 5.35e-10 | 4.77e-08 | 39 |
GO:00709979 | Breast | Precancer | neuron death | 50/1080 | 361/18723 | 7.75e-09 | 5.70e-07 | 50 |
GO:00514029 | Breast | Precancer | neuron apoptotic process | 38/1080 | 246/18723 | 2.68e-08 | 1.75e-06 | 38 |
GO:00345999 | Breast | Precancer | cellular response to oxidative stress | 42/1080 | 288/18723 | 2.78e-08 | 1.79e-06 | 42 |
GO:00309018 | Breast | Precancer | midbrain development | 20/1080 | 90/18723 | 1.50e-07 | 7.93e-06 | 20 |
GO:19012149 | Breast | Precancer | regulation of neuron death | 41/1080 | 319/18723 | 1.27e-06 | 4.80e-05 | 41 |
GO:00435237 | Breast | Precancer | regulation of neuron apoptotic process | 31/1080 | 212/18723 | 1.69e-06 | 6.08e-05 | 31 |
GO:00435243 | Breast | Precancer | negative regulation of neuron apoptotic process | 19/1080 | 145/18723 | 6.83e-04 | 8.34e-03 | 19 |
GO:00454444 | Breast | Precancer | fat cell differentiation | 26/1080 | 229/18723 | 7.60e-04 | 9.04e-03 | 26 |
GO:00714969 | Breast | Precancer | cellular response to external stimulus | 33/1080 | 320/18723 | 9.01e-04 | 1.03e-02 | 33 |
GO:19012157 | Breast | Precancer | negative regulation of neuron death | 24/1080 | 208/18723 | 9.50e-04 | 1.07e-02 | 24 |
GO:00316688 | Breast | Precancer | cellular response to extracellular stimulus | 27/1080 | 246/18723 | 1.02e-03 | 1.13e-02 | 27 |
GO:00140753 | Breast | Precancer | response to amine | 9/1080 | 49/18723 | 1.74e-03 | 1.74e-02 | 9 |
GO:0001975 | Breast | Precancer | response to amphetamine | 7/1080 | 33/18723 | 2.37e-03 | 2.19e-02 | 7 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0492812 | Cervix | CC | Parathyroid hormone synthesis, secretion and action | 27/1267 | 106/8465 | 3.12e-03 | 1.19e-02 | 7.03e-03 | 27 |
hsa0492813 | Cervix | CC | Parathyroid hormone synthesis, secretion and action | 27/1267 | 106/8465 | 3.12e-03 | 1.19e-02 | 7.03e-03 | 27 |
hsa0492816 | Esophagus | ESCC | Parathyroid hormone synthesis, secretion and action | 66/4205 | 106/8465 | 5.86e-03 | 1.47e-02 | 7.51e-03 | 66 |
hsa0492817 | Esophagus | ESCC | Parathyroid hormone synthesis, secretion and action | 66/4205 | 106/8465 | 5.86e-03 | 1.47e-02 | 7.51e-03 | 66 |
hsa0492810 | Lung | IAC | Parathyroid hormone synthesis, secretion and action | 26/1053 | 106/8465 | 4.34e-04 | 4.03e-03 | 2.68e-03 | 26 |
hsa0492811 | Lung | IAC | Parathyroid hormone synthesis, secretion and action | 26/1053 | 106/8465 | 4.34e-04 | 4.03e-03 | 2.68e-03 | 26 |
hsa0492814 | Prostate | BPH | Parathyroid hormone synthesis, secretion and action | 33/1718 | 106/8465 | 5.30e-03 | 1.75e-02 | 1.08e-02 | 33 |
hsa0492815 | Prostate | BPH | Parathyroid hormone synthesis, secretion and action | 33/1718 | 106/8465 | 5.30e-03 | 1.75e-02 | 1.08e-02 | 33 |
hsa0492822 | Prostate | Tumor | Parathyroid hormone synthesis, secretion and action | 35/1791 | 106/8465 | 2.89e-03 | 1.07e-02 | 6.67e-03 | 35 |
hsa0492832 | Prostate | Tumor | Parathyroid hormone synthesis, secretion and action | 35/1791 | 106/8465 | 2.89e-03 | 1.07e-02 | 6.67e-03 | 35 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NR4A2 | SNV | Missense_Mutation | c.1028G>T | p.Gly343Val | p.G343V | P43354 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
NR4A2 | SNV | Missense_Mutation | novel | c.872N>C | p.Val291Ala | p.V291A | P43354 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
NR4A2 | deletion | Frame_Shift_Del | c.430delG | p.Asp144ThrfsTer19 | p.D144Tfs*19 | P43354 | protein_coding | TCGA-E2-A1IF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |||
NR4A2 | SNV | Missense_Mutation | c.833G>T | p.Arg278Leu | p.R278L | P43354 | protein_coding | deleterious(0.01) | probably_damaging(0.92) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NR4A2 | SNV | Missense_Mutation | c.52G>A | p.Ala18Thr | p.A18T | P43354 | protein_coding | deleterious(0.03) | possibly_damaging(0.656) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NR4A2 | SNV | Missense_Mutation | c.16N>A | p.Ala6Thr | p.A6T | P43354 | protein_coding | tolerated(0.33) | benign(0.339) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
NR4A2 | SNV | Missense_Mutation | c.866N>A | p.Arg289His | p.R289H | P43354 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NR4A2 | SNV | Missense_Mutation | novel | c.503C>T | p.Thr168Met | p.T168M | P43354 | protein_coding | deleterious(0.03) | benign(0.11) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
NR4A2 | SNV | Missense_Mutation | novel | c.1145N>G | p.Leu382Arg | p.L382R | P43354 | protein_coding | deleterious(0.01) | benign(0.436) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
NR4A2 | SNV | Missense_Mutation | novel | c.214N>A | p.Asp72Asn | p.D72N | P43354 | protein_coding | tolerated(0.07) | probably_damaging(0.932) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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