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Gene: MT1E |
Gene summary for MT1E |
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Gene information | Species | Human | Gene symbol | MT1E | Gene ID | 4493 |
Gene name | metallothionein 1E | |
Gene Alias | MT-1E | |
Cytomap | 16q13 | |
Gene Type | protein-coding | GO ID | GO:0006873 | UniProtAcc | P04732 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4493 | MT1E | P91T-E | Human | Esophagus | ESCC | 5.00e-05 | 2.14e+00 | 0.1828 |
4493 | MT1E | P94T-E | Human | Esophagus | ESCC | 1.70e-05 | 2.04e+00 | 0.0879 |
4493 | MT1E | P104T-E | Human | Esophagus | ESCC | 3.23e-18 | 3.02e+00 | 0.0931 |
4493 | MT1E | P107T-E | Human | Esophagus | ESCC | 2.20e-56 | 3.09e+00 | 0.171 |
4493 | MT1E | P126T-E | Human | Esophagus | ESCC | 1.50e-09 | 2.77e+00 | 0.1125 |
4493 | MT1E | P128T-E | Human | Esophagus | ESCC | 3.79e-52 | 5.00e+00 | 0.1241 |
4493 | MT1E | P130T-E | Human | Esophagus | ESCC | 2.94e-62 | 3.56e+00 | 0.1676 |
4493 | MT1E | NAFLD1 | Human | Liver | NAFLD | 9.36e-03 | -8.25e-01 | -0.04 |
4493 | MT1E | S41 | Human | Liver | Cirrhotic | 3.90e-02 | -6.59e-01 | -0.0343 |
4493 | MT1E | S42 | Human | Liver | HCC | 1.62e-04 | -6.69e-01 | -0.0103 |
4493 | MT1E | S43 | Human | Liver | Cirrhotic | 4.37e-25 | -2.50e-01 | -0.0187 |
4493 | MT1E | S44 | Human | Liver | HCC | 3.91e-05 | -9.37e-01 | -0.0083 |
4493 | MT1E | HCC1_Meng | Human | Liver | HCC | 4.05e-59 | -1.21e+00 | 0.0246 |
4493 | MT1E | HCC2_Meng | Human | Liver | HCC | 1.27e-49 | -8.88e-01 | 0.0107 |
4493 | MT1E | cirrhotic1 | Human | Liver | Cirrhotic | 1.10e-23 | 3.29e-01 | 0.0202 |
4493 | MT1E | cirrhotic2 | Human | Liver | Cirrhotic | 5.21e-29 | 3.92e-02 | 0.0201 |
4493 | MT1E | cirrhotic3 | Human | Liver | Cirrhotic | 2.61e-08 | 2.10e-01 | 0.0215 |
4493 | MT1E | p6 | Human | Liver | Cyst | 3.05e-16 | -1.22e+00 | -0.0218 |
4493 | MT1E | HCC1 | Human | Liver | HCC | 1.94e-30 | -8.50e-01 | 0.5336 |
4493 | MT1E | HCC2 | Human | Liver | HCC | 5.89e-14 | 2.81e+00 | 0.5341 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00100389 | Breast | Precancer | response to metal ion | 47/1080 | 373/18723 | 3.88e-07 | 1.79e-05 | 47 |
GO:00987548 | Breast | Precancer | detoxification | 24/1080 | 152/18723 | 6.49e-06 | 1.81e-04 | 24 |
GO:00466868 | Breast | Precancer | response to cadmium ion | 14/1080 | 68/18723 | 2.74e-05 | 6.21e-04 | 14 |
GO:00096368 | Breast | Precancer | response to toxic substance | 31/1080 | 262/18723 | 1.18e-04 | 2.12e-03 | 31 |
GO:00550767 | Breast | Precancer | transition metal ion homeostasis | 20/1080 | 138/18723 | 1.28e-04 | 2.24e-03 | 20 |
GO:00469165 | Breast | Precancer | cellular transition metal ion homeostasis | 17/1080 | 115/18723 | 3.15e-04 | 4.49e-03 | 17 |
GO:00712767 | Breast | Precancer | cellular response to cadmium ion | 9/1080 | 40/18723 | 3.69e-04 | 5.03e-03 | 9 |
GO:00712488 | Breast | Precancer | cellular response to metal ion | 24/1080 | 197/18723 | 4.35e-04 | 5.79e-03 | 24 |
GO:00712418 | Breast | Precancer | cellular response to inorganic substance | 26/1080 | 226/18723 | 6.23e-04 | 7.78e-03 | 26 |
GO:00975017 | Breast | Precancer | stress response to metal ion | 5/1080 | 19/18723 | 3.73e-03 | 3.04e-02 | 5 |
GO:00100435 | Breast | Precancer | response to zinc ion | 9/1080 | 58/18723 | 5.67e-03 | 4.08e-02 | 9 |
GO:0072503 | Breast | Precancer | cellular divalent inorganic cation homeostasis | 42/1080 | 486/18723 | 5.91e-03 | 4.21e-02 | 42 |
GO:001003814 | Breast | IDC | response to metal ion | 65/1434 | 373/18723 | 2.95e-10 | 3.42e-08 | 65 |
GO:004668613 | Breast | IDC | response to cadmium ion | 19/1434 | 68/18723 | 4.97e-07 | 2.45e-05 | 19 |
GO:000963613 | Breast | IDC | response to toxic substance | 44/1434 | 262/18723 | 6.33e-07 | 3.00e-05 | 44 |
GO:009875413 | Breast | IDC | detoxification | 29/1434 | 152/18723 | 3.97e-06 | 1.43e-04 | 29 |
GO:007127613 | Breast | IDC | cellular response to cadmium ion | 11/1434 | 40/18723 | 1.48e-04 | 2.60e-03 | 11 |
GO:005507613 | Breast | IDC | transition metal ion homeostasis | 23/1434 | 138/18723 | 3.20e-04 | 4.79e-03 | 23 |
GO:001004311 | Breast | IDC | response to zinc ion | 13/1434 | 58/18723 | 3.59e-04 | 5.18e-03 | 13 |
GO:004691612 | Breast | IDC | cellular transition metal ion homeostasis | 20/1434 | 115/18723 | 4.35e-04 | 5.90e-03 | 20 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0497812 | Breast | IDC | Mineral absorption | 13/867 | 60/8465 | 6.73e-03 | 3.42e-02 | 2.56e-02 | 13 |
hsa0497813 | Breast | IDC | Mineral absorption | 13/867 | 60/8465 | 6.73e-03 | 3.42e-02 | 2.56e-02 | 13 |
hsa0497821 | Breast | DCIS | Mineral absorption | 13/846 | 60/8465 | 5.48e-03 | 2.81e-02 | 2.07e-02 | 13 |
hsa0497831 | Breast | DCIS | Mineral absorption | 13/846 | 60/8465 | 5.48e-03 | 2.81e-02 | 2.07e-02 | 13 |
hsa0497810 | Liver | Cyst | Mineral absorption | 8/339 | 60/8465 | 2.53e-03 | 2.08e-02 | 1.72e-02 | 8 |
hsa0497811 | Liver | Cyst | Mineral absorption | 8/339 | 60/8465 | 2.53e-03 | 2.08e-02 | 1.72e-02 | 8 |
hsa0497814 | Prostate | BPH | Mineral absorption | 20/1718 | 60/8465 | 1.22e-02 | 3.61e-02 | 2.23e-02 | 20 |
hsa0497815 | Prostate | BPH | Mineral absorption | 20/1718 | 60/8465 | 1.22e-02 | 3.61e-02 | 2.23e-02 | 20 |
hsa04978 | Stomach | GC | Mineral absorption | 15/708 | 60/8465 | 8.88e-05 | 9.80e-04 | 6.90e-04 | 15 |
hsa049781 | Stomach | GC | Mineral absorption | 15/708 | 60/8465 | 8.88e-05 | 9.80e-04 | 6.90e-04 | 15 |
hsa049782 | Stomach | CAG with IM | Mineral absorption | 12/640 | 60/8465 | 1.52e-03 | 1.01e-02 | 7.10e-03 | 12 |
hsa049783 | Stomach | CAG with IM | Mineral absorption | 12/640 | 60/8465 | 1.52e-03 | 1.01e-02 | 7.10e-03 | 12 |
hsa049784 | Stomach | CSG | Mineral absorption | 11/633 | 60/8465 | 4.40e-03 | 2.53e-02 | 1.82e-02 | 11 |
hsa049785 | Stomach | CSG | Mineral absorption | 11/633 | 60/8465 | 4.40e-03 | 2.53e-02 | 1.82e-02 | 11 |
hsa049786 | Stomach | CAG | Mineral absorption | 8/368 | 60/8465 | 4.18e-03 | 2.94e-02 | 2.36e-02 | 8 |
hsa049787 | Stomach | CAG | Mineral absorption | 8/368 | 60/8465 | 4.18e-03 | 2.94e-02 | 2.36e-02 | 8 |
hsa049788 | Stomach | SIM | Mineral absorption | 11/465 | 60/8465 | 3.61e-04 | 3.41e-03 | 2.74e-03 | 11 |
hsa049789 | Stomach | SIM | Mineral absorption | 11/465 | 60/8465 | 3.61e-04 | 3.41e-03 | 2.74e-03 | 11 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MT1E | SNV | Missense_Mutation | c.88N>G | p.Lys30Glu | p.K30E | P04732 | protein_coding | deleterious(0.02) | benign(0.049) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MT1E | SNV | Missense_Mutation | novel | c.22G>A | p.Ala8Thr | p.A8T | P04732 | protein_coding | tolerated(0.42) | benign(0) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MT1E | SNV | Missense_Mutation | novel | c.40N>G | p.Thr14Ala | p.T14A | P04732 | protein_coding | tolerated(0.31) | benign(0.001) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MT1E | SNV | Missense_Mutation | novel | c.40N>G | p.Thr14Ala | p.T14A | P04732 | protein_coding | tolerated(0.31) | benign(0.001) | TCGA-FI-A2D6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MT1E | SNV | Missense_Mutation | c.124N>T | p.Ala42Ser | p.A42S | P04732 | protein_coding | tolerated(0.13) | benign(0.023) | TCGA-G3-A7M5-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4493 | MT1E | NA | NAC | ACETYLCYSTEINE | 7592595 |
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