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Gene: MRPS21 |
Gene summary for MRPS21 |
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Gene information | Species | Human | Gene symbol | MRPS21 | Gene ID | 54460 |
Gene name | mitochondrial ribosomal protein S21 | |
Gene Alias | MDS016 | |
Cytomap | 1q21.2 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | P82921 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54460 | MRPS21 | P62T-E | Human | Esophagus | ESCC | 2.24e-67 | 1.50e+00 | 0.1302 |
54460 | MRPS21 | P65T-E | Human | Esophagus | ESCC | 4.46e-35 | 9.00e-01 | 0.0978 |
54460 | MRPS21 | P74T-E | Human | Esophagus | ESCC | 1.40e-51 | 1.80e+00 | 0.1479 |
54460 | MRPS21 | P75T-E | Human | Esophagus | ESCC | 1.07e-45 | 9.33e-01 | 0.1125 |
54460 | MRPS21 | P76T-E | Human | Esophagus | ESCC | 6.95e-77 | 1.70e+00 | 0.1207 |
54460 | MRPS21 | P79T-E | Human | Esophagus | ESCC | 6.06e-35 | 9.04e-01 | 0.1154 |
54460 | MRPS21 | P80T-E | Human | Esophagus | ESCC | 2.40e-50 | 1.77e+00 | 0.155 |
54460 | MRPS21 | P82T-E | Human | Esophagus | ESCC | 1.19e-32 | 1.98e+00 | 0.1072 |
54460 | MRPS21 | P83T-E | Human | Esophagus | ESCC | 2.21e-67 | 2.57e+00 | 0.1738 |
54460 | MRPS21 | P84T-E | Human | Esophagus | ESCC | 5.30e-12 | 1.16e+00 | 0.0933 |
54460 | MRPS21 | P89T-E | Human | Esophagus | ESCC | 8.75e-37 | 2.93e+00 | 0.1752 |
54460 | MRPS21 | P91T-E | Human | Esophagus | ESCC | 1.05e-20 | 2.84e+00 | 0.1828 |
54460 | MRPS21 | P94T-E | Human | Esophagus | ESCC | 1.21e-02 | 1.33e+00 | 0.0879 |
54460 | MRPS21 | P107T-E | Human | Esophagus | ESCC | 2.76e-87 | 2.88e+00 | 0.171 |
54460 | MRPS21 | P126T-E | Human | Esophagus | ESCC | 3.50e-13 | 1.82e+00 | 0.1125 |
54460 | MRPS21 | P127T-E | Human | Esophagus | ESCC | 7.53e-34 | 9.41e-01 | 0.0826 |
54460 | MRPS21 | P128T-E | Human | Esophagus | ESCC | 5.01e-54 | 2.34e+00 | 0.1241 |
54460 | MRPS21 | P130T-E | Human | Esophagus | ESCC | 2.45e-89 | 2.28e+00 | 0.1676 |
54460 | MRPS21 | S41 | Human | Liver | Cirrhotic | 5.29e-05 | -6.77e-01 | -0.0343 |
54460 | MRPS21 | S42 | Human | Liver | HCC | 2.67e-02 | -6.77e-01 | -0.0103 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00325432 | Breast | IDC | mitochondrial translation | 13/1434 | 76/18723 | 4.81e-03 | 3.67e-02 | 13 |
GO:003254311 | Breast | DCIS | mitochondrial translation | 13/1390 | 76/18723 | 3.70e-03 | 2.99e-02 | 13 |
GO:00325435 | Esophagus | HGIN | mitochondrial translation | 23/2587 | 76/18723 | 1.61e-04 | 3.16e-03 | 23 |
GO:01400534 | Esophagus | HGIN | mitochondrial gene expression | 27/2587 | 108/18723 | 1.34e-03 | 1.57e-02 | 27 |
GO:014005313 | Esophagus | ESCC | mitochondrial gene expression | 93/8552 | 108/18723 | 1.96e-18 | 2.03e-16 | 93 |
GO:003254314 | Esophagus | ESCC | mitochondrial translation | 68/8552 | 76/18723 | 1.02e-15 | 6.86e-14 | 68 |
GO:0032543 | Liver | Cirrhotic | mitochondrial translation | 40/4634 | 76/18723 | 1.61e-07 | 4.29e-06 | 40 |
GO:0140053 | Liver | Cirrhotic | mitochondrial gene expression | 49/4634 | 108/18723 | 2.35e-06 | 4.31e-05 | 49 |
GO:01400531 | Liver | HCC | mitochondrial gene expression | 82/7958 | 108/18723 | 1.49e-12 | 7.20e-11 | 82 |
GO:00325431 | Liver | HCC | mitochondrial translation | 62/7958 | 76/18723 | 2.95e-12 | 1.34e-10 | 62 |
GO:01400533 | Oral cavity | OSCC | mitochondrial gene expression | 78/7305 | 108/18723 | 2.37e-12 | 9.86e-11 | 78 |
GO:00325434 | Oral cavity | OSCC | mitochondrial translation | 59/7305 | 76/18723 | 7.21e-12 | 2.70e-10 | 59 |
GO:003254313 | Oral cavity | LP | mitochondrial translation | 43/4623 | 76/18723 | 2.85e-09 | 1.26e-07 | 43 |
GO:014005312 | Oral cavity | LP | mitochondrial gene expression | 53/4623 | 108/18723 | 3.54e-08 | 1.27e-06 | 53 |
GO:00325433 | Prostate | BPH | mitochondrial translation | 23/3107 | 76/18723 | 2.21e-03 | 1.22e-02 | 23 |
GO:01400532 | Prostate | BPH | mitochondrial gene expression | 29/3107 | 108/18723 | 4.68e-03 | 2.25e-02 | 29 |
GO:003254312 | Prostate | Tumor | mitochondrial translation | 24/3246 | 76/18723 | 1.73e-03 | 1.03e-02 | 24 |
GO:014005311 | Prostate | Tumor | mitochondrial gene expression | 31/3246 | 108/18723 | 2.31e-03 | 1.30e-02 | 31 |
GO:00325436 | Skin | cSCC | mitochondrial translation | 47/4864 | 76/18723 | 4.70e-11 | 2.22e-09 | 47 |
GO:01400535 | Skin | cSCC | mitochondrial gene expression | 56/4864 | 108/18723 | 8.06e-09 | 2.56e-07 | 56 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301024 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0301034 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0301044 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0301054 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa03010 | Colorectum | AD | Ribosome | 96/2092 | 167/8465 | 8.28e-20 | 5.54e-18 | 3.54e-18 | 96 |
hsa030101 | Colorectum | AD | Ribosome | 96/2092 | 167/8465 | 8.28e-20 | 5.54e-18 | 3.54e-18 | 96 |
hsa030102 | Colorectum | SER | Ribosome | 92/1580 | 167/8465 | 2.21e-26 | 3.66e-24 | 2.66e-24 | 92 |
hsa030103 | Colorectum | SER | Ribosome | 92/1580 | 167/8465 | 2.21e-26 | 3.66e-24 | 2.66e-24 | 92 |
hsa030104 | Colorectum | MSS | Ribosome | 96/1875 | 167/8465 | 1.82e-23 | 2.03e-21 | 1.24e-21 | 96 |
hsa030105 | Colorectum | MSS | Ribosome | 96/1875 | 167/8465 | 1.82e-23 | 2.03e-21 | 1.24e-21 | 96 |
hsa0301026 | Endometrium | AEH | Ribosome | 89/1197 | 167/8465 | 1.88e-33 | 6.09e-31 | 4.46e-31 | 89 |
hsa03010112 | Endometrium | AEH | Ribosome | 89/1197 | 167/8465 | 1.88e-33 | 6.09e-31 | 4.46e-31 | 89 |
hsa0301027 | Endometrium | EEC | Ribosome | 89/1237 | 167/8465 | 2.55e-32 | 8.39e-30 | 6.26e-30 | 89 |
hsa0301036 | Endometrium | EEC | Ribosome | 89/1237 | 167/8465 | 2.55e-32 | 8.39e-30 | 6.26e-30 | 89 |
hsa0301039 | Esophagus | HGIN | Ribosome | 108/1383 | 167/8465 | 1.44e-45 | 4.71e-43 | 3.74e-43 | 108 |
hsa03010115 | Esophagus | HGIN | Ribosome | 108/1383 | 167/8465 | 1.44e-45 | 4.71e-43 | 3.74e-43 | 108 |
hsa03010211 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
hsa03010310 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
hsa0301022 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
hsa0301032 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRPS21 | SNV | Missense_Mutation | c.128N>A | p.Arg43Gln | p.R43Q | protein_coding | tolerated(0.21) | benign(0.041) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MRPS21 | SNV | Missense_Mutation | rs782778925 | c.155G>A | p.Arg52Gln | p.R52Q | protein_coding | tolerated(0.05) | benign(0.041) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
MRPS21 | SNV | Missense_Mutation | novel | c.26N>A | p.Ala9Asp | p.A9D | protein_coding | tolerated(0.06) | benign(0.244) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MRPS21 | SNV | Missense_Mutation | c.242C>T | p.Ala81Val | p.A81V | protein_coding | tolerated(0.45) | benign(0.003) | TCGA-AG-3894-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
MRPS21 | SNV | Missense_Mutation | novel | c.20N>A | p.Phe7Tyr | p.F7Y | protein_coding | deleterious(0.05) | probably_damaging(0.923) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
MRPS21 | SNV | Missense_Mutation | rs782225927 | c.209N>A | p.Arg70His | p.R70H | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
MRPS21 | SNV | Missense_Mutation | rs371854457 | c.182N>A | p.Arg61Gln | p.R61Q | protein_coding | tolerated(0.14) | benign(0.01) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
MRPS21 | SNV | Missense_Mutation | rs781892346 | c.151C>T | p.Arg51Trp | p.R51W | protein_coding | tolerated(0.11) | benign(0.014) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response | |
MRPS21 | SNV | Missense_Mutation | c.28N>T | p.Arg10Trp | p.R10W | protein_coding | deleterious(0.01) | benign(0.191) | TCGA-CC-A7IK-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | ||
MRPS21 | SNV | Missense_Mutation | c.185G>T | p.Arg62Leu | p.R62L | protein_coding | deleterious(0.05) | possibly_damaging(0.626) | TCGA-50-5049-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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