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Gene: MRPL27 |
Gene summary for MRPL27 |
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Gene information | Species | Human | Gene symbol | MRPL27 | Gene ID | 51264 |
Gene name | mitochondrial ribosomal protein L27 | |
Gene Alias | L27mt | |
Cytomap | 17q21.33 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | Q9P0M9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51264 | MRPL27 | S015 | Human | Liver | HCC | 5.87e-24 | 1.58e+00 | 0.2375 |
51264 | MRPL27 | S016 | Human | Liver | HCC | 6.44e-32 | 1.50e+00 | 0.2243 |
51264 | MRPL27 | S027 | Human | Liver | HCC | 1.16e-11 | 1.39e+00 | 0.2446 |
51264 | MRPL27 | S028 | Human | Liver | HCC | 1.56e-16 | 1.37e+00 | 0.2503 |
51264 | MRPL27 | S029 | Human | Liver | HCC | 5.92e-17 | 1.68e+00 | 0.2581 |
51264 | MRPL27 | C04 | Human | Oral cavity | OSCC | 6.56e-49 | 2.28e+00 | 0.2633 |
51264 | MRPL27 | C21 | Human | Oral cavity | OSCC | 4.23e-61 | 2.22e+00 | 0.2678 |
51264 | MRPL27 | C30 | Human | Oral cavity | OSCC | 8.07e-54 | 3.35e+00 | 0.3055 |
51264 | MRPL27 | C38 | Human | Oral cavity | OSCC | 2.33e-13 | 1.67e+00 | 0.172 |
51264 | MRPL27 | C43 | Human | Oral cavity | OSCC | 2.25e-37 | 9.93e-01 | 0.1704 |
51264 | MRPL27 | C46 | Human | Oral cavity | OSCC | 2.73e-41 | 9.49e-01 | 0.1673 |
51264 | MRPL27 | C51 | Human | Oral cavity | OSCC | 3.75e-34 | 1.65e+00 | 0.2674 |
51264 | MRPL27 | C57 | Human | Oral cavity | OSCC | 3.69e-18 | 8.27e-01 | 0.1679 |
51264 | MRPL27 | C06 | Human | Oral cavity | OSCC | 1.91e-15 | 2.37e+00 | 0.2699 |
51264 | MRPL27 | C07 | Human | Oral cavity | OSCC | 8.66e-10 | 1.77e+00 | 0.2491 |
51264 | MRPL27 | C08 | Human | Oral cavity | OSCC | 3.97e-48 | 1.24e+00 | 0.1919 |
51264 | MRPL27 | C09 | Human | Oral cavity | OSCC | 2.38e-20 | 6.17e-01 | 0.1431 |
51264 | MRPL27 | LN22 | Human | Oral cavity | OSCC | 7.96e-15 | 1.47e+00 | 0.1733 |
51264 | MRPL27 | LN38 | Human | Oral cavity | OSCC | 2.28e-11 | 1.46e+00 | 0.168 |
51264 | MRPL27 | LN46 | Human | Oral cavity | OSCC | 2.00e-31 | 1.34e+00 | 0.1666 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301018 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0301019 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0301024 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0301034 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0301044 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0301054 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa03010 | Colorectum | AD | Ribosome | 96/2092 | 167/8465 | 8.28e-20 | 5.54e-18 | 3.54e-18 | 96 |
hsa030101 | Colorectum | AD | Ribosome | 96/2092 | 167/8465 | 8.28e-20 | 5.54e-18 | 3.54e-18 | 96 |
hsa030102 | Colorectum | SER | Ribosome | 92/1580 | 167/8465 | 2.21e-26 | 3.66e-24 | 2.66e-24 | 92 |
hsa030103 | Colorectum | SER | Ribosome | 92/1580 | 167/8465 | 2.21e-26 | 3.66e-24 | 2.66e-24 | 92 |
hsa030104 | Colorectum | MSS | Ribosome | 96/1875 | 167/8465 | 1.82e-23 | 2.03e-21 | 1.24e-21 | 96 |
hsa030105 | Colorectum | MSS | Ribosome | 96/1875 | 167/8465 | 1.82e-23 | 2.03e-21 | 1.24e-21 | 96 |
hsa0301039 | Esophagus | HGIN | Ribosome | 108/1383 | 167/8465 | 1.44e-45 | 4.71e-43 | 3.74e-43 | 108 |
hsa03010115 | Esophagus | HGIN | Ribosome | 108/1383 | 167/8465 | 1.44e-45 | 4.71e-43 | 3.74e-43 | 108 |
hsa03010211 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
hsa03010310 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
hsa0301022 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
hsa0301032 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
hsa0301042 | Liver | HCC | Ribosome | 128/4020 | 167/8465 | 7.32e-15 | 2.23e-13 | 1.24e-13 | 128 |
hsa0301052 | Liver | HCC | Ribosome | 128/4020 | 167/8465 | 7.32e-15 | 2.23e-13 | 1.24e-13 | 128 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRPL27 | SNV | Missense_Mutation | novel | c.58N>T | p.Pro20Ser | p.P20S | Q9P0M9 | protein_coding | tolerated(0.09) | benign(0) | TCGA-A8-A06Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MRPL27 | insertion | Nonsense_Mutation | novel | c.55_56insAATATGGTTAAAAACTGTATATACAACACAGTTTAATCTCTCT | p.Ser19LysfsTer4 | p.S19Kfs*4 | Q9P0M9 | protein_coding | TCGA-A8-A06Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MRPL27 | SNV | Missense_Mutation | c.384G>T | p.Lys128Asn | p.K128N | Q9P0M9 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
MRPL27 | SNV | Missense_Mutation | rs768545678 | c.148C>T | p.Arg50Cys | p.R50C | Q9P0M9 | protein_coding | tolerated(0.13) | benign(0.053) | TCGA-AJ-A3OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
MRPL27 | SNV | Missense_Mutation | c.356N>A | p.Arg119Lys | p.R119K | Q9P0M9 | protein_coding | tolerated(0.61) | benign(0) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MRPL27 | SNV | Missense_Mutation | c.43A>G | p.Thr15Ala | p.T15A | Q9P0M9 | protein_coding | tolerated(0.75) | benign(0.015) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
MRPL27 | SNV | Missense_Mutation | rs763878672 | c.221N>A | p.Arg74His | p.R74H | Q9P0M9 | protein_coding | deleterious(0.01) | benign(0.157) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRPL27 | SNV | Missense_Mutation | rs750648679 | c.212N>A | p.Arg71His | p.R71H | Q9P0M9 | protein_coding | tolerated(0.07) | possibly_damaging(0.896) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
MRPL27 | SNV | Missense_Mutation | novel | c.307N>A | p.Val103Ile | p.V103I | Q9P0M9 | protein_coding | tolerated(0.1) | probably_damaging(0.999) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRPL27 | SNV | Missense_Mutation | novel | c.287N>C | p.Ile96Thr | p.I96T | Q9P0M9 | protein_coding | tolerated(0.41) | benign(0.007) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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