Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57496 | MKL2 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 2.98e-16 | 5.45e-01 | 0.1608 |
57496 | MKL2 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 1.63e-12 | 5.83e-01 | 0.1604 |
57496 | MKL2 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 1.24e-08 | 3.93e-01 | 0.1621 |
57496 | MKL2 | GSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002 | Human | Prostate | Tumor | 3.50e-02 | 3.33e-01 | 0.1619 |
57496 | MKL2 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 1.73e-08 | 4.39e-01 | 0.1602 |
57496 | MKL2 | GSM5353236_PA_PR5251_T1_S7_L001 | Human | Prostate | Tumor | 5.58e-07 | 5.40e-01 | 0.1608 |
57496 | MKL2 | GSM5353237_PA_PR5251_T2_S8_L001 | Human | Prostate | Tumor | 4.40e-03 | 3.84e-01 | 0.1622 |
57496 | MKL2 | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 8.26e-14 | 4.87e-01 | 0.1575 |
57496 | MKL2 | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 1.82e-02 | 2.34e-01 | 0.1545 |
57496 | MKL2 | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 1.00e-06 | 3.90e-01 | 0.1569 |
57496 | MKL2 | PTC01 | Human | Thyroid | PTC | 7.47e-10 | 4.81e-02 | 0.1899 |
57496 | MKL2 | PTC04 | Human | Thyroid | PTC | 1.64e-22 | 2.80e-01 | 0.1927 |
57496 | MKL2 | PTC05 | Human | Thyroid | PTC | 2.98e-19 | 5.13e-01 | 0.2065 |
57496 | MKL2 | PTC06 | Human | Thyroid | PTC | 1.90e-23 | 4.00e-01 | 0.2057 |
57496 | MKL2 | PTC07 | Human | Thyroid | PTC | 7.50e-33 | 2.56e-01 | 0.2044 |
57496 | MKL2 | ATC11 | Human | Thyroid | ATC | 8.93e-03 | 2.01e-01 | 0.3386 |
57496 | MKL2 | ATC12 | Human | Thyroid | ATC | 2.62e-10 | 6.91e-03 | 0.34 |
57496 | MKL2 | ATC13 | Human | Thyroid | ATC | 1.17e-23 | 4.88e-01 | 0.34 |
57496 | MKL2 | ATC3 | Human | Thyroid | ATC | 1.19e-02 | 1.48e-01 | 0.338 |
57496 | MKL2 | ATC4 | Human | Thyroid | ATC | 6.03e-08 | 3.19e-02 | 0.34 |
Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/MKL2_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/MKL2_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/MKL2_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/MKL2_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/MKL2_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MKL2 | SNV | Missense_Mutation | | c.1450N>C | p.Glu484Gln | p.E484Q | Q9ULH7 | protein_coding | tolerated(0.44) | benign(0.011) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
MKL2 | SNV | Missense_Mutation | | c.1364N>C | p.Val455Ala | p.V455A | Q9ULH7 | protein_coding | tolerated(0.26) | benign(0) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MKL2 | SNV | Missense_Mutation | | c.72N>C | p.Gln24His | p.Q24H | Q9ULH7 | protein_coding | tolerated(0.14) | benign(0.003) | TCGA-AC-A2B8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | chemo | PD |
MKL2 | SNV | Missense_Mutation | novel | c.2546N>A | p.Gly849Glu | p.G849E | Q9ULH7 | protein_coding | deleterious(0) | benign(0.038) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MKL2 | SNV | Missense_Mutation | | c.1077C>G | p.Phe359Leu | p.F359L | Q9ULH7 | protein_coding | tolerated(1) | benign(0) | TCGA-BH-A18V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MKL2 | SNV | Missense_Mutation | | c.946N>A | p.Glu316Lys | p.E316K | Q9ULH7 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-C8-A1HM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR |
MKL2 | SNV | Missense_Mutation | novel | c.2362N>C | p.Phe788Leu | p.F788L | Q9ULH7 | protein_coding | tolerated(0.62) | benign(0.087) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD |
MKL2 | SNV | Missense_Mutation | rs767875492 | c.2863N>T | p.Arg955Trp | p.R955W | Q9ULH7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A1Y1-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | PD |
MKL2 | deletion | Frame_Shift_Del | novel | c.2130delT | p.Val711LeufsTer8 | p.V711Lfs*8 | Q9ULH7 | protein_coding | | | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
MKL2 | SNV | Missense_Mutation | | c.439N>G | p.Gln147Glu | p.Q147E | Q9ULH7 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-EA-A439-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |