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Gene: KIF13B |
Gene summary for KIF13B |
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Gene information | Species | Human | Gene symbol | KIF13B | Gene ID | 23303 |
Gene name | kinesin family member 13B | |
Gene Alias | GAKIN | |
Cytomap | 8p12 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q9NQT8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23303 | KIF13B | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 5.05e-10 | 6.17e-01 | 0.1633 |
23303 | KIF13B | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 1.30e-04 | 4.05e-01 | 0.1608 |
23303 | KIF13B | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 6.17e-03 | 4.28e-01 | 0.1604 |
23303 | KIF13B | Pat01-B | Human | Stomach | GC | 2.09e-25 | 5.05e-01 | 0.5754 |
23303 | KIF13B | Pat02-B | Human | Stomach | GC | 6.68e-23 | 3.17e-01 | 0.0368 |
23303 | KIF13B | Pat03-B | Human | Stomach | GC | 2.02e-23 | 4.38e-01 | 0.3693 |
23303 | KIF13B | Pat04-B | Human | Stomach | GC | 4.99e-11 | 2.52e-01 | -0.1483 |
23303 | KIF13B | Pat05-B | Human | Stomach | GC | 4.74e-05 | 3.43e-01 | -0.0353 |
23303 | KIF13B | Pat06-B | Human | Stomach | GC | 2.63e-23 | 3.02e-01 | -0.1961 |
23303 | KIF13B | Pat11-B | Human | Stomach | GC | 4.22e-04 | 2.14e-01 | -0.182 |
23303 | KIF13B | Pat12-B | Human | Stomach | GC | 5.53e-20 | 4.57e-01 | 0.0325 |
23303 | KIF13B | Pat13-B | Human | Stomach | GC | 4.05e-04 | 2.87e-01 | 0.0555 |
23303 | KIF13B | Pat15-B | Human | Stomach | GC | 8.41e-14 | 3.96e-01 | -0.0778 |
23303 | KIF13B | Pat16-B | Human | Stomach | GC | 3.36e-07 | 2.77e-01 | 0.1918 |
23303 | KIF13B | Pat17-B | Human | Stomach | GC | 4.67e-06 | 2.69e-01 | 0.3109 |
23303 | KIF13B | Pat18-B | Human | Stomach | GC | 4.05e-07 | 2.68e-01 | -0.0432 |
23303 | KIF13B | Pat19-B | Human | Stomach | GC | 8.12e-10 | 3.58e-01 | 0.0826 |
23303 | KIF13B | Pat22-B | Human | Stomach | GC | 6.98e-20 | 3.40e-01 | -0.1042 |
23303 | KIF13B | Pat24-B | Human | Stomach | GC | 3.65e-03 | 2.38e-01 | -0.1184 |
23303 | KIF13B | Pat25-A | Human | Stomach | CAG with IM | 4.48e-12 | 1.40e-01 | -0.1648 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006605 | Colorectum | AD | protein targeting | 105/3918 | 314/18723 | 1.39e-07 | 6.44e-06 | 105 |
GO:0010975 | Colorectum | AD | regulation of neuron projection development | 129/3918 | 445/18723 | 2.88e-05 | 5.37e-04 | 129 |
GO:0007409 | Colorectum | AD | axonogenesis | 122/3918 | 418/18723 | 3.36e-05 | 6.15e-04 | 122 |
GO:0061564 | Colorectum | AD | axon development | 132/3918 | 467/18723 | 8.40e-05 | 1.31e-03 | 132 |
GO:0050770 | Colorectum | AD | regulation of axonogenesis | 49/3918 | 154/18723 | 9.88e-04 | 9.28e-03 | 49 |
GO:00066051 | Colorectum | SER | protein targeting | 76/2897 | 314/18723 | 3.19e-05 | 8.47e-04 | 76 |
GO:00109751 | Colorectum | SER | regulation of neuron projection development | 92/2897 | 445/18723 | 1.85e-03 | 1.89e-02 | 92 |
GO:00615641 | Colorectum | SER | axon development | 94/2897 | 467/18723 | 3.78e-03 | 3.13e-02 | 94 |
GO:00074091 | Colorectum | SER | axonogenesis | 84/2897 | 418/18723 | 6.20e-03 | 4.49e-02 | 84 |
GO:00066052 | Colorectum | MSS | protein targeting | 97/3467 | 314/18723 | 6.76e-08 | 3.46e-06 | 97 |
GO:00109752 | Colorectum | MSS | regulation of neuron projection development | 115/3467 | 445/18723 | 6.91e-05 | 1.20e-03 | 115 |
GO:00074092 | Colorectum | MSS | axonogenesis | 105/3467 | 418/18723 | 4.32e-04 | 5.23e-03 | 105 |
GO:00615642 | Colorectum | MSS | axon development | 115/3467 | 467/18723 | 5.33e-04 | 6.00e-03 | 115 |
GO:00507701 | Colorectum | MSS | regulation of axonogenesis | 43/3467 | 154/18723 | 2.69e-03 | 2.12e-02 | 43 |
GO:00615643 | Colorectum | FAP | axon development | 106/2622 | 467/18723 | 1.98e-07 | 1.21e-05 | 106 |
GO:00109753 | Colorectum | FAP | regulation of neuron projection development | 102/2622 | 445/18723 | 2.04e-07 | 1.24e-05 | 102 |
GO:00074093 | Colorectum | FAP | axonogenesis | 97/2622 | 418/18723 | 2.20e-07 | 1.30e-05 | 97 |
GO:00066054 | Colorectum | FAP | protein targeting | 74/2622 | 314/18723 | 3.21e-06 | 1.17e-04 | 74 |
GO:00507702 | Colorectum | FAP | regulation of axonogenesis | 42/2622 | 154/18723 | 1.11e-05 | 3.10e-04 | 42 |
GO:00074094 | Colorectum | CRC | axonogenesis | 81/2078 | 418/18723 | 3.60e-07 | 2.99e-05 | 81 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa048144 | Endometrium | AEH | Motor proteins | 42/1197 | 193/8465 | 2.41e-03 | 1.42e-02 | 1.04e-02 | 42 |
hsa0481411 | Endometrium | AEH | Motor proteins | 42/1197 | 193/8465 | 2.41e-03 | 1.42e-02 | 1.04e-02 | 42 |
hsa048142 | Endometrium | EEC | Motor proteins | 42/1237 | 193/8465 | 4.43e-03 | 2.39e-02 | 1.78e-02 | 42 |
hsa048143 | Endometrium | EEC | Motor proteins | 42/1237 | 193/8465 | 4.43e-03 | 2.39e-02 | 1.78e-02 | 42 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIF13B | SNV | Missense_Mutation | novel | c.1851N>T | p.Gln617His | p.Q617H | Q9NQT8 | protein_coding | deleterious(0.03) | benign(0.141) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIF13B | SNV | Missense_Mutation | novel | c.2320G>A | p.Glu774Lys | p.E774K | Q9NQT8 | protein_coding | tolerated(0.54) | benign(0.062) | TCGA-BH-A0B0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
KIF13B | SNV | Missense_Mutation | rs759564273 | c.3275N>A | p.Arg1092His | p.R1092H | Q9NQT8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-D8-A1JE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamicin | SD |
KIF13B | SNV | Missense_Mutation | rs753292093 | c.2935N>T | p.Arg979Trp | p.R979W | Q9NQT8 | protein_coding | deleterious(0.01) | probably_damaging(0.982) | TCGA-E9-A1NG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | letrozole | SD |
KIF13B | SNV | Missense_Mutation | novel | c.340A>G | p.Met114Val | p.M114V | Q9NQT8 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
KIF13B | insertion | In_Frame_Ins | novel | c.1235_1236insTCTTTCAAAATCTATTTCTGACAG | p.Glu412delinsAspLeuSerLysSerIleSerAspArg | p.E412delinsDLSKSISDR | Q9NQT8 | protein_coding | TCGA-A2-A04V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | PD | ||
KIF13B | insertion | Nonsense_Mutation | novel | c.4135_4136insTACATGGGGTTGTTTCATAACAGTGG | p.Ser1379IlefsTer7 | p.S1379Ifs*7 | Q9NQT8 | protein_coding | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
KIF13B | insertion | Frame_Shift_Ins | novel | c.4133_4134insTGGTGTCCATGCGTCA | p.Arg1378SerfsTer64 | p.R1378Sfs*64 | Q9NQT8 | protein_coding | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
KIF13B | insertion | Nonsense_Mutation | novel | c.4147_4148insAAGGCGGATAACGTCTCATTTATTCAGAAAATGA | p.Pro1383GlnfsTer4 | p.P1383Qfs*4 | Q9NQT8 | protein_coding | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD | ||
KIF13B | SNV | Missense_Mutation | rs192432763 | c.5374N>A | p.Ala1792Thr | p.A1792T | Q9NQT8 | protein_coding | tolerated(0.3) | benign(0.009) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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