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Gene: IER5L |
Gene summary for IER5L |
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Gene information | Species | Human | Gene symbol | IER5L | Gene ID | 389792 |
Gene name | immediate early response 5 like | |
Gene Alias | bA247A12.2 | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q5T953 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
389792 | IER5L | PTC07 | Human | Thyroid | PTC | 8.05e-48 | 9.42e-01 | 0.2044 |
389792 | IER5L | ATC09 | Human | Thyroid | ATC | 1.44e-03 | 1.82e-01 | 0.2871 |
389792 | IER5L | ATC12 | Human | Thyroid | ATC | 2.06e-25 | 5.57e-01 | 0.34 |
389792 | IER5L | ATC13 | Human | Thyroid | ATC | 7.54e-47 | 1.03e+00 | 0.34 |
389792 | IER5L | ATC1 | Human | Thyroid | ATC | 1.59e-02 | 1.86e-01 | 0.2878 |
389792 | IER5L | ATC2 | Human | Thyroid | ATC | 4.88e-15 | 1.10e+00 | 0.34 |
389792 | IER5L | ATC4 | Human | Thyroid | ATC | 3.43e-29 | 7.36e-01 | 0.34 |
389792 | IER5L | ATC5 | Human | Thyroid | ATC | 4.83e-58 | 1.15e+00 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IER5L | insertion | Nonsense_Mutation | novel | c.7_8insAATGAGGGAA | p.Cys3Ter | p.C3* | Q5T953 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
IER5L | deletion | Frame_Shift_Del | c.978delN | p.Gly328AlafsTer29 | p.G328Afs*29 | Q5T953 | protein_coding | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |||
IER5L | deletion | Frame_Shift_Del | c.978delC | p.Gly328AlafsTer29 | p.G328Afs*29 | Q5T953 | protein_coding | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
IER5L | SNV | Missense_Mutation | novel | c.26N>A | p.Ser9Asn | p.S9N | Q5T953 | protein_coding | tolerated_low_confidence(0.3) | benign(0.096) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IER5L | SNV | Missense_Mutation | novel | c.731C>G | p.Ser244Trp | p.S244W | Q5T953 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.984) | TCGA-NJ-A4YP-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
IER5L | SNV | Missense_Mutation | rs763398316 | c.34A>G | p.Ser12Gly | p.S12G | Q5T953 | protein_coding | deleterious_low_confidence(0.01) | benign(0.132) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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