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Gene: GPR108 |
Gene summary for GPR108 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GPR108 | Gene ID | 56927 |
| Gene name | G protein-coupled receptor 108 | |
| Gene Alias | LUSTR2 | |
| Cytomap | 19p13.3 | |
| Gene Type | protein-coding | GO ID | GO:0002221 | UniProtAcc | Q9NPR9 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 56927 | GPR108 | SYSMH2 | Human | Oral cavity | OSCC | 1.02e-16 | 4.75e-01 | 0.2326 |
| 56927 | GPR108 | SYSMH3 | Human | Oral cavity | OSCC | 2.26e-21 | 5.28e-01 | 0.2442 |
| 56927 | GPR108 | SYSMH5 | Human | Oral cavity | OSCC | 2.88e-07 | 2.70e-01 | 0.0647 |
| 56927 | GPR108 | SYSMH6 | Human | Oral cavity | OSCC | 6.28e-13 | 3.89e-01 | 0.1275 |
| 56927 | GPR108 | P1_cSCC | Human | Skin | cSCC | 8.06e-13 | 7.08e-01 | 0.0292 |
| 56927 | GPR108 | P2_cSCC | Human | Skin | cSCC | 4.38e-02 | 2.59e-01 | -0.024 |
| 56927 | GPR108 | P4_cSCC | Human | Skin | cSCC | 1.25e-04 | 3.55e-01 | -0.00290000000000005 |
| 56927 | GPR108 | P10_cSCC | Human | Skin | cSCC | 9.32e-11 | 5.11e-01 | 0.1017 |
| 56927 | GPR108 | cSCC_p8 | Human | Skin | cSCC | 7.89e-03 | 6.08e-02 | -0.1971 |
| 56927 | GPR108 | male-WTA | Human | Thyroid | PTC | 2.27e-40 | 3.80e-01 | 0.1037 |
| 56927 | GPR108 | PTC01 | Human | Thyroid | PTC | 3.58e-28 | 6.35e-01 | 0.1899 |
| 56927 | GPR108 | PTC04 | Human | Thyroid | PTC | 1.24e-12 | 3.33e-01 | 0.1927 |
| 56927 | GPR108 | PTC05 | Human | Thyroid | PTC | 6.87e-23 | 8.61e-01 | 0.2065 |
| 56927 | GPR108 | PTC06 | Human | Thyroid | PTC | 5.23e-40 | 8.69e-01 | 0.2057 |
| 56927 | GPR108 | PTC07 | Human | Thyroid | PTC | 7.71e-49 | 7.70e-01 | 0.2044 |
| 56927 | GPR108 | ATC09 | Human | Thyroid | ATC | 2.92e-11 | 2.61e-01 | 0.2871 |
| 56927 | GPR108 | ATC11 | Human | Thyroid | ATC | 1.33e-02 | 2.25e-01 | 0.3386 |
| 56927 | GPR108 | ATC12 | Human | Thyroid | ATC | 1.67e-05 | 1.57e-01 | 0.34 |
| 56927 | GPR108 | ATC13 | Human | Thyroid | ATC | 2.26e-20 | 4.35e-01 | 0.34 |
| 56927 | GPR108 | ATC1 | Human | Thyroid | ATC | 1.18e-11 | 3.04e-01 | 0.2878 |
| Page: 1 2 3 4 5 6 7 8 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0002221 | Colorectum | MSS | pattern recognition receptor signaling pathway | 45/3467 | 172/18723 | 8.06e-03 | 4.91e-02 | 45 |
| GO:00022211 | Liver | HCC | pattern recognition receptor signaling pathway | 107/7958 | 172/18723 | 1.37e-07 | 2.58e-06 | 107 |
| GO:0002224 | Liver | HCC | toll-like receptor signaling pathway | 67/7958 | 121/18723 | 2.87e-03 | 1.34e-02 | 67 |
| GO:00622072 | Liver | HCC | regulation of pattern recognition receptor signaling pathway | 59/7958 | 105/18723 | 3.18e-03 | 1.47e-02 | 59 |
| GO:00022214 | Oral cavity | OSCC | pattern recognition receptor signaling pathway | 95/7305 | 172/18723 | 1.11e-05 | 1.15e-04 | 95 |
| GO:00622076 | Oral cavity | OSCC | regulation of pattern recognition receptor signaling pathway | 56/7305 | 105/18723 | 1.99e-03 | 9.23e-03 | 56 |
| GO:00022243 | Oral cavity | OSCC | toll-like receptor signaling pathway | 63/7305 | 121/18723 | 2.36e-03 | 1.04e-02 | 63 |
| GO:00027646 | Oral cavity | OSCC | immune response-regulating signaling pathway | 212/7305 | 468/18723 | 2.93e-03 | 1.27e-02 | 212 |
| GO:00022215 | Thyroid | PTC | pattern recognition receptor signaling pathway | 77/5968 | 172/18723 | 2.56e-04 | 1.84e-03 | 77 |
| GO:000222114 | Thyroid | ATC | pattern recognition receptor signaling pathway | 80/6293 | 172/18723 | 2.89e-04 | 1.84e-03 | 80 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| GPR108 | SNV | Missense_Mutation | rs757468810 | c.1363N>A | p.Val455Ile | p.V455I | Q9NPR9 | protein_coding | tolerated(1) | benign(0.003) | TCGA-A2-A0T0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
| GPR108 | SNV | Missense_Mutation | rs376404694 | c.625N>A | p.Val209Met | p.V209M | Q9NPR9 | protein_coding | tolerated(0.44) | benign(0.048) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| GPR108 | SNV | Missense_Mutation | novel | c.951N>G | p.Ile317Met | p.I317M | Q9NPR9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
| GPR108 | deletion | Frame_Shift_Del | novel | c.683delN | p.Asn228ThrfsTer15 | p.N228Tfs*15 | Q9NPR9 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
| GPR108 | SNV | Missense_Mutation | novel | c.1095N>C | p.Lys365Asn | p.K365N | Q9NPR9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| GPR108 | SNV | Missense_Mutation | novel | c.1264N>T | p.Arg422Trp | p.R422W | Q9NPR9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
| GPR108 | SNV | Missense_Mutation | c.209G>A | p.Gly70Asp | p.G70D | Q9NPR9 | protein_coding | tolerated(0.33) | benign(0.001) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
| GPR108 | SNV | Missense_Mutation | c.1568A>G | p.Asp523Gly | p.D523G | Q9NPR9 | protein_coding | tolerated(0.36) | benign(0.003) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| GPR108 | SNV | Missense_Mutation | rs746123266 | c.857N>T | p.Thr286Met | p.T286M | Q9NPR9 | protein_coding | deleterious(0.02) | possibly_damaging(0.806) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| GPR108 | SNV | Missense_Mutation | rs769102342 | c.973N>A | p.Glu325Lys | p.E325K | Q9NPR9 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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