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Gene: GPHN |
Gene summary for GPHN |
Gene summary. |
Gene information | Species | Human | Gene symbol | GPHN | Gene ID | 10243 |
Gene name | gephyrin | |
Gene Alias | GEPH | |
Cytomap | 14q23.3-q24.1 | |
Gene Type | protein-coding | GO ID | GO:0001941 | UniProtAcc | Q9NQX3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10243 | GPHN | cirrhotic1 | Human | Liver | Cirrhotic | 9.10e-10 | -3.87e-01 | 0.0202 |
10243 | GPHN | cirrhotic2 | Human | Liver | Cirrhotic | 2.08e-13 | -3.79e-01 | 0.0201 |
10243 | GPHN | cirrhotic3 | Human | Liver | Cirrhotic | 4.51e-05 | -4.15e-01 | 0.0215 |
10243 | GPHN | Pt13.a | Human | Liver | HCC | 1.90e-11 | -4.42e-01 | 0.021 |
10243 | GPHN | Pt13.b | Human | Liver | HCC | 3.87e-04 | -4.15e-01 | 0.0251 |
10243 | GPHN | Pt14.d | Human | Liver | HCC | 7.65e-09 | -3.88e-01 | 0.0143 |
10243 | GPHN | S014 | Human | Liver | HCC | 1.52e-05 | 1.37e-01 | 0.2254 |
10243 | GPHN | S015 | Human | Liver | HCC | 3.09e-02 | 1.92e-01 | 0.2375 |
10243 | GPHN | S016 | Human | Liver | HCC | 1.26e-06 | 2.35e-01 | 0.2243 |
10243 | GPHN | S029 | Human | Liver | HCC | 6.01e-08 | -1.66e-01 | 0.2581 |
10243 | GPHN | TD9 | Human | Lung | IAC | 2.26e-05 | 8.03e-01 | 0.088 |
10243 | GPHN | RNA-P10T2-P10T2-1 | Human | Lung | AAH | 6.34e-04 | 8.13e-01 | -0.1271 |
10243 | GPHN | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 3.86e-02 | 5.64e-01 | -0.1406 |
10243 | GPHN | RNA-P17T-P17T-2 | Human | Lung | IAC | 3.33e-10 | 1.03e+00 | 0.3371 |
10243 | GPHN | RNA-P17T-P17T-4 | Human | Lung | IAC | 1.77e-11 | 9.49e-01 | 0.343 |
10243 | GPHN | RNA-P17T-P17T-6 | Human | Lung | IAC | 3.81e-11 | 9.78e-01 | 0.3385 |
10243 | GPHN | RNA-P17T-P17T-8 | Human | Lung | IAC | 1.44e-07 | 8.59e-01 | 0.3329 |
10243 | GPHN | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 2.54e-33 | 1.28e+00 | -0.2116 |
10243 | GPHN | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 3.21e-17 | 1.39e+00 | -0.1941 |
10243 | GPHN | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 6.70e-16 | 1.19e+00 | -0.2107 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001003810 | Cervix | CC | response to metal ion | 67/2311 | 373/18723 | 9.67e-04 | 8.10e-03 | 67 |
GO:0010038 | Colorectum | AD | response to metal ion | 106/3918 | 373/18723 | 3.22e-04 | 3.83e-03 | 106 |
GO:0099173 | Colorectum | AD | postsynapse organization | 51/3918 | 168/18723 | 2.47e-03 | 1.90e-02 | 51 |
GO:0050808 | Colorectum | AD | synapse organization | 112/3918 | 426/18723 | 4.25e-03 | 2.92e-02 | 112 |
GO:0099072 | Colorectum | AD | regulation of postsynaptic membrane neurotransmitter receptor levels | 22/3918 | 62/18723 | 5.72e-03 | 3.64e-02 | 22 |
GO:00991731 | Colorectum | SER | postsynapse organization | 46/2897 | 168/18723 | 5.20e-05 | 1.25e-03 | 46 |
GO:00100381 | Colorectum | SER | response to metal ion | 84/2897 | 373/18723 | 1.87e-04 | 3.44e-03 | 84 |
GO:00508081 | Colorectum | SER | synapse organization | 85/2897 | 426/18723 | 7.17e-03 | 4.99e-02 | 85 |
GO:00991732 | Colorectum | MSS | postsynapse organization | 48/3467 | 168/18723 | 9.32e-04 | 9.44e-03 | 48 |
GO:00990721 | Colorectum | MSS | regulation of postsynaptic membrane neurotransmitter receptor levels | 21/3467 | 62/18723 | 2.87e-03 | 2.23e-02 | 21 |
GO:00100382 | Colorectum | MSS | response to metal ion | 90/3467 | 373/18723 | 3.76e-03 | 2.76e-02 | 90 |
GO:00508082 | Colorectum | MSS | synapse organization | 101/3467 | 426/18723 | 3.96e-03 | 2.89e-02 | 101 |
GO:00100383 | Colorectum | MSI-H | response to metal ion | 41/1319 | 373/18723 | 3.09e-03 | 3.87e-02 | 41 |
GO:00508083 | Colorectum | FAP | synapse organization | 91/2622 | 426/18723 | 1.90e-05 | 4.74e-04 | 91 |
GO:00991733 | Colorectum | FAP | postsynapse organization | 42/2622 | 168/18723 | 1.01e-04 | 1.70e-03 | 42 |
GO:00990722 | Colorectum | FAP | regulation of postsynaptic membrane neurotransmitter receptor levels | 18/2622 | 62/18723 | 1.60e-03 | 1.42e-02 | 18 |
GO:00100384 | Colorectum | FAP | response to metal ion | 70/2622 | 373/18723 | 5.95e-03 | 3.75e-02 | 70 |
GO:00991734 | Colorectum | CRC | postsynapse organization | 36/2078 | 168/18723 | 7.61e-05 | 1.59e-03 | 36 |
GO:00508084 | Colorectum | CRC | synapse organization | 71/2078 | 426/18723 | 3.02e-04 | 4.76e-03 | 71 |
GO:00990723 | Colorectum | CRC | regulation of postsynaptic membrane neurotransmitter receptor levels | 16/2078 | 62/18723 | 9.40e-04 | 1.15e-02 | 16 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012405 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa0124012 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa012402 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa012403 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa012404 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
hsa0124011 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPHN | SNV | Missense_Mutation | c.2209C>T | p.Arg737Cys | p.R737C | Q9NQX3 | protein_coding | deleterious(0.01) | probably_damaging(0.963) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GPHN | SNV | Missense_Mutation | c.88C>A | p.Leu30Ile | p.L30I | Q9NQX3 | protein_coding | tolerated(0.07) | probably_damaging(0.948) | TCGA-E9-A1RH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
GPHN | SNV | Missense_Mutation | novel | c.34N>A | p.Asp12Asn | p.D12N | Q9NQX3 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.988) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GPHN | SNV | Missense_Mutation | c.226N>A | p.Glu76Lys | p.E76K | Q9NQX3 | protein_coding | tolerated(0.31) | benign(0.069) | TCGA-JW-AAVH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
GPHN | SNV | Missense_Mutation | c.1962N>G | p.Ile654Met | p.I654M | Q9NQX3 | protein_coding | deleterious(0.01) | possibly_damaging(0.812) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GPHN | SNV | Missense_Mutation | c.1874C>T | p.Ala625Val | p.A625V | Q9NQX3 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GPHN | SNV | Missense_Mutation | c.1988N>T | p.Ser663Leu | p.S663L | Q9NQX3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
GPHN | SNV | Missense_Mutation | c.817N>G | p.Thr273Ala | p.T273A | Q9NQX3 | protein_coding | tolerated(0.64) | benign(0) | TCGA-AA-A01I-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GPHN | SNV | Missense_Mutation | c.317N>A | p.Arg106Gln | p.R106Q | Q9NQX3 | protein_coding | deleterious(0.01) | possibly_damaging(0.457) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
GPHN | SNV | Missense_Mutation | c.1976N>T | p.Gly659Val | p.G659V | Q9NQX3 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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