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Gene: GLRX5 |
Gene summary for GLRX5 |
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Gene information | Species | Human | Gene symbol | GLRX5 | Gene ID | 51218 |
Gene name | glutaredoxin 5 | |
Gene Alias | C14orf87 | |
Cytomap | 14q32.13 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q86SX6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51218 | GLRX5 | PTC06 | Human | Thyroid | PTC | 3.67e-47 | 1.23e+00 | 0.2057 |
51218 | GLRX5 | PTC07 | Human | Thyroid | PTC | 5.96e-59 | 9.79e-01 | 0.2044 |
51218 | GLRX5 | ATC08 | Human | Thyroid | ATC | 1.41e-10 | 2.57e-01 | 0.0541 |
51218 | GLRX5 | ATC09 | Human | Thyroid | ATC | 2.33e-09 | 2.46e-01 | 0.2871 |
51218 | GLRX5 | ATC11 | Human | Thyroid | ATC | 6.57e-03 | 5.80e-01 | 0.3386 |
51218 | GLRX5 | ATC12 | Human | Thyroid | ATC | 1.80e-25 | 6.26e-01 | 0.34 |
51218 | GLRX5 | ATC13 | Human | Thyroid | ATC | 3.59e-20 | 4.33e-01 | 0.34 |
51218 | GLRX5 | ATC1 | Human | Thyroid | ATC | 6.43e-09 | 3.14e-01 | 0.2878 |
51218 | GLRX5 | ATC2 | Human | Thyroid | ATC | 1.53e-18 | 1.40e+00 | 0.34 |
51218 | GLRX5 | ATC3 | Human | Thyroid | ATC | 3.40e-06 | 3.85e-01 | 0.338 |
51218 | GLRX5 | ATC4 | Human | Thyroid | ATC | 1.17e-33 | 8.40e-01 | 0.34 |
51218 | GLRX5 | ATC5 | Human | Thyroid | ATC | 1.08e-28 | 4.87e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
GO:0051604 | Colorectum | AD | protein maturation | 85/3918 | 294/18723 | 6.73e-04 | 6.91e-03 | 85 |
GO:00516041 | Colorectum | SER | protein maturation | 73/2897 | 294/18723 | 1.82e-05 | 5.38e-04 | 73 |
GO:00067901 | Colorectum | SER | sulfur compound metabolic process | 73/2897 | 339/18723 | 1.75e-03 | 1.81e-02 | 73 |
GO:00067902 | Colorectum | MSS | sulfur compound metabolic process | 85/3467 | 339/18723 | 1.52e-03 | 1.39e-02 | 85 |
GO:00516042 | Colorectum | MSS | protein maturation | 75/3467 | 294/18723 | 1.70e-03 | 1.53e-02 | 75 |
GO:005160417 | Esophagus | HGIN | protein maturation | 68/2587 | 294/18723 | 9.77e-06 | 2.86e-04 | 68 |
GO:00974282 | Esophagus | HGIN | protein maturation by iron-sulfur cluster transfer | 8/2587 | 16/18723 | 6.00e-04 | 8.41e-03 | 8 |
GO:00162263 | Esophagus | HGIN | iron-sulfur cluster assembly | 10/2587 | 26/18723 | 1.60e-03 | 1.79e-02 | 10 |
GO:00311633 | Esophagus | HGIN | metallo-sulfur cluster assembly | 10/2587 | 26/18723 | 1.60e-03 | 1.79e-02 | 10 |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:001622611 | Esophagus | ESCC | iron-sulfur cluster assembly | 21/8552 | 26/18723 | 2.69e-04 | 1.63e-03 | 21 |
GO:003116311 | Esophagus | ESCC | metallo-sulfur cluster assembly | 21/8552 | 26/18723 | 2.69e-04 | 1.63e-03 | 21 |
GO:009742811 | Esophagus | ESCC | protein maturation by iron-sulfur cluster transfer | 14/8552 | 16/18723 | 6.78e-04 | 3.56e-03 | 14 |
GO:00516046 | Liver | Cirrhotic | protein maturation | 121/4634 | 294/18723 | 3.54e-10 | 1.68e-08 | 121 |
GO:000679011 | Liver | Cirrhotic | sulfur compound metabolic process | 129/4634 | 339/18723 | 3.06e-08 | 1.04e-06 | 129 |
GO:000679021 | Liver | HCC | sulfur compound metabolic process | 212/7958 | 339/18723 | 5.60e-14 | 3.39e-12 | 212 |
GO:005160412 | Liver | HCC | protein maturation | 171/7958 | 294/18723 | 3.80e-08 | 8.30e-07 | 171 |
GO:0016226 | Liver | HCC | iron-sulfur cluster assembly | 18/7958 | 26/18723 | 5.37e-03 | 2.24e-02 | 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GLRX5 | insertion | Nonsense_Mutation | novel | c.433_434insAGTAGCAGA | p.Ser145delinsTer | p.S145delins* | Q86SX6 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
GLRX5 | SNV | Missense_Mutation | novel | c.333N>T | p.Gln111His | p.Q111H | Q86SX6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-34-2604-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GLRX5 | SNV | Missense_Mutation | c.444A>T | p.Leu148Phe | p.L148F | Q86SX6 | protein_coding | deleterious(0.05) | possibly_damaging(0.786) | TCGA-51-4079-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GLRX5 | SNV | Missense_Mutation | c.304G>T | p.Asp102Tyr | p.D102Y | Q86SX6 | protein_coding | deleterious(0.03) | probably_damaging(0.979) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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