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Gene: GLG1 |
Gene summary for GLG1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | GLG1 | Gene ID | 2734 |
Gene name | golgi glycoprotein 1 | |
Gene Alias | CFR-1 | |
Cytomap | 16q23.1 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q92896 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2734 | GLG1 | RNA-P17T-P17T-6 | Human | Lung | IAC | 1.25e-02 | 5.14e-01 | 0.3385 |
2734 | GLG1 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 4.10e-05 | 3.31e-01 | -0.2116 |
2734 | GLG1 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 1.06e-04 | 6.41e-01 | -0.1941 |
2734 | GLG1 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 3.33e-03 | 4.60e-01 | -0.2107 |
2734 | GLG1 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 3.18e-12 | 5.81e-01 | -0.2119 |
2734 | GLG1 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 5.94e-03 | 5.38e-01 | -0.0263 |
2734 | GLG1 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 2.13e-13 | 5.06e-01 | -0.0166 |
2734 | GLG1 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 2.85e-19 | 5.22e-01 | -0.0132 |
2734 | GLG1 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 4.15e-23 | 6.13e-01 | -0.013 |
2734 | GLG1 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 3.45e-11 | 4.05e-01 | -0.0121 |
2734 | GLG1 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 1.43e-02 | 4.05e-01 | -0.0809 |
2734 | GLG1 | C04 | Human | Oral cavity | OSCC | 1.04e-18 | 1.29e+00 | 0.2633 |
2734 | GLG1 | C21 | Human | Oral cavity | OSCC | 9.15e-50 | 1.63e+00 | 0.2678 |
2734 | GLG1 | C30 | Human | Oral cavity | OSCC | 1.29e-35 | 1.66e+00 | 0.3055 |
2734 | GLG1 | C38 | Human | Oral cavity | OSCC | 4.72e-06 | 7.96e-01 | 0.172 |
2734 | GLG1 | C43 | Human | Oral cavity | OSCC | 2.01e-25 | 5.95e-01 | 0.1704 |
2734 | GLG1 | C46 | Human | Oral cavity | OSCC | 1.09e-07 | 3.99e-01 | 0.1673 |
2734 | GLG1 | C51 | Human | Oral cavity | OSCC | 7.44e-18 | 1.11e+00 | 0.2674 |
2734 | GLG1 | C57 | Human | Oral cavity | OSCC | 1.70e-03 | 4.40e-01 | 0.1679 |
2734 | GLG1 | C06 | Human | Oral cavity | OSCC | 1.04e-05 | 1.27e+00 | 0.2699 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004586110 | Cervix | CC | negative regulation of proteolysis | 80/2311 | 351/18723 | 2.88e-08 | 1.98e-06 | 80 |
GO:00071786 | Cervix | CC | transmembrane receptor protein serine/threonine kinase signaling pathway | 67/2311 | 355/18723 | 2.39e-04 | 2.67e-03 | 67 |
GO:00516048 | Cervix | CC | protein maturation | 56/2311 | 294/18723 | 5.90e-04 | 5.59e-03 | 56 |
GO:00715595 | Cervix | CC | response to transforming growth factor beta | 50/2311 | 256/18723 | 6.31e-04 | 5.91e-03 | 50 |
GO:00715605 | Cervix | CC | cellular response to transforming growth factor beta stimulus | 49/2311 | 250/18723 | 6.55e-04 | 6.05e-03 | 49 |
GO:00071795 | Cervix | CC | transforming growth factor beta receptor signaling pathway | 38/2311 | 198/18723 | 3.62e-03 | 2.31e-02 | 38 |
GO:004586124 | Cervix | N_HPV | negative regulation of proteolysis | 27/534 | 351/18723 | 3.27e-06 | 1.36e-04 | 27 |
GO:007156023 | Cervix | N_HPV | cellular response to transforming growth factor beta stimulus | 18/534 | 250/18723 | 3.16e-04 | 4.75e-03 | 18 |
GO:005160414 | Cervix | N_HPV | protein maturation | 20/534 | 294/18723 | 3.17e-04 | 4.75e-03 | 20 |
GO:007155923 | Cervix | N_HPV | response to transforming growth factor beta | 18/534 | 256/18723 | 4.21e-04 | 5.88e-03 | 18 |
GO:000717821 | Cervix | N_HPV | transmembrane receptor protein serine/threonine kinase signaling pathway | 22/534 | 355/18723 | 5.85e-04 | 7.73e-03 | 22 |
GO:00603482 | Cervix | N_HPV | bone development | 15/534 | 205/18723 | 8.27e-04 | 1.02e-02 | 15 |
GO:000717922 | Cervix | N_HPV | transforming growth factor beta receptor signaling pathway | 14/534 | 198/18723 | 1.69e-03 | 1.72e-02 | 14 |
GO:00164854 | Cervix | N_HPV | protein processing | 15/534 | 225/18723 | 2.09e-03 | 2.00e-02 | 15 |
GO:0045861 | Colorectum | AD | negative regulation of proteolysis | 106/3918 | 351/18723 | 2.33e-05 | 4.57e-04 | 106 |
GO:0051604 | Colorectum | AD | protein maturation | 85/3918 | 294/18723 | 6.73e-04 | 6.91e-03 | 85 |
GO:0007178 | Colorectum | AD | transmembrane receptor protein serine/threonine kinase signaling pathway | 99/3918 | 355/18723 | 9.92e-04 | 9.28e-03 | 99 |
GO:0071559 | Colorectum | AD | response to transforming growth factor beta | 74/3918 | 256/18723 | 1.45e-03 | 1.23e-02 | 74 |
GO:0071560 | Colorectum | AD | cellular response to transforming growth factor beta stimulus | 72/3918 | 250/18723 | 1.85e-03 | 1.52e-02 | 72 |
GO:0007179 | Colorectum | AD | transforming growth factor beta receptor signaling pathway | 59/3918 | 198/18723 | 1.94e-03 | 1.58e-02 | 59 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa045147 | Cervix | CC | Cell adhesion molecules | 36/1267 | 157/8465 | 4.94e-03 | 1.67e-02 | 9.86e-03 | 36 |
hsa0451412 | Cervix | CC | Cell adhesion molecules | 36/1267 | 157/8465 | 4.94e-03 | 1.67e-02 | 9.86e-03 | 36 |
hsa0451441 | Cervix | N_HPV | Cell adhesion molecules | 18/349 | 157/8465 | 7.71e-05 | 8.06e-04 | 6.30e-04 | 18 |
hsa0451451 | Cervix | N_HPV | Cell adhesion molecules | 18/349 | 157/8465 | 7.71e-05 | 8.06e-04 | 6.30e-04 | 18 |
hsa045146 | Lung | IAC | Cell adhesion molecules | 30/1053 | 157/8465 | 1.03e-02 | 3.83e-02 | 2.54e-02 | 30 |
hsa0451411 | Lung | IAC | Cell adhesion molecules | 30/1053 | 157/8465 | 1.03e-02 | 3.83e-02 | 2.54e-02 | 30 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
SELE | GLG1 | SELE_GLG1 | SELE | Breast | ADJ |
SELE | GLG1 | SELE_GLG1 | SELE | Breast | Healthy |
SELE | GLG1 | SELE_GLG1 | SELE | Cervix | ADJ |
SELE | GLG1 | SELE_GLG1 | SELE | Cervix | CC |
SELE | GLG1 | SELE_GLG1 | SELE | Endometrium | ADJ |
SELE | GLG1 | SELE_GLG1 | SELE | Endometrium | AEH |
SELE | GLG1 | SELE_GLG1 | SELE | Endometrium | EEC |
SELE | GLG1 | SELE_GLG1 | SELE | Esophagus | ESCC |
SELE | GLG1 | SELE_GLG1 | SELE | GC | Healthy |
SELE | GLG1 | SELE_GLG1 | SELE | HNSCC | ADJ |
SELE | GLG1 | SELE_GLG1 | SELE | HNSCC | Healthy |
SELE | GLG1 | SELE_GLG1 | SELE | HNSCC | OSCC |
SELE | GLG1 | SELE_GLG1 | SELE | HNSCC | Precancer |
SELE | GLG1 | SELE_GLG1 | SELE | Prostate | ADJ |
SELE | GLG1 | SELE_GLG1 | SELE | Prostate | BPH |
SELE | GLG1 | SELE_GLG1 | SELE | Prostate | Healthy |
SELE | GLG1 | SELE_GLG1 | SELE | Prostate | Tumor |
SELE | GLG1 | SELE_GLG1 | SELE | Skin | ADJ |
SELE | GLG1 | SELE_GLG1 | SELE | Skin | AK |
SELE | GLG1 | SELE_GLG1 | SELE | Skin | cSCC |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GLG1 | SNV | Missense_Mutation | c.1717C>G | p.Arg573Gly | p.R573G | Q92896 | protein_coding | deleterious(0.01) | possibly_damaging(0.524) | TCGA-A7-A0CE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
GLG1 | SNV | Missense_Mutation | novel | c.2081N>A | p.Arg694Lys | p.R694K | Q92896 | protein_coding | tolerated(0.25) | possibly_damaging(0.553) | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR |
GLG1 | SNV | Missense_Mutation | rs763398161 | c.1621N>A | p.Asp541Asn | p.D541N | Q92896 | protein_coding | tolerated(0.2) | benign(0.122) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
GLG1 | SNV | Missense_Mutation | novel | c.3442C>A | p.Leu1148Ile | p.L1148I | Q92896 | protein_coding | tolerated(0.12) | probably_damaging(0.986) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GLG1 | SNV | Missense_Mutation | c.2171N>G | p.Asn724Ser | p.N724S | Q92896 | protein_coding | tolerated(0.05) | probably_damaging(0.939) | TCGA-D8-A1JJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
GLG1 | deletion | Frame_Shift_Del | c.2499_2500delCT | p.Phe833LeufsTer32 | p.F833Lfs*32 | Q92896 | protein_coding | TCGA-AC-A23C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | chemo | CR | |||
GLG1 | SNV | Missense_Mutation | novel | c.3331C>T | p.Arg1111Cys | p.R1111C | Q92896 | protein_coding | deleterious(0.01) | probably_damaging(0.95) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GLG1 | SNV | Missense_Mutation | c.623N>A | p.Arg208Gln | p.R208Q | Q92896 | protein_coding | tolerated(0.12) | possibly_damaging(0.749) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
GLG1 | SNV | Missense_Mutation | novel | c.2575T>C | p.Cys859Arg | p.C859R | Q92896 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
GLG1 | SNV | Missense_Mutation | c.1043G>A | p.Ser348Asn | p.S348N | Q92896 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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