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Gene: EMC3 |
Gene summary for EMC3 |
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Gene information | Species | Human | Gene symbol | EMC3 | Gene ID | 55831 |
Gene name | ER membrane protein complex subunit 3 | |
Gene Alias | POB | |
Cytomap | 3p25.3 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q9P0I2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55831 | EMC3 | SYSMH4 | Human | Oral cavity | OSCC | 8.62e-03 | 1.47e-01 | 0.1226 |
55831 | EMC3 | SYSMH5 | Human | Oral cavity | OSCC | 1.20e-03 | 3.00e-01 | 0.0647 |
55831 | EMC3 | SYSMH6 | Human | Oral cavity | OSCC | 2.82e-10 | 4.36e-01 | 0.1275 |
55831 | EMC3 | P4_S8_cSCC | Human | Skin | cSCC | 6.40e-07 | 1.88e-01 | -0.3095 |
55831 | EMC3 | P5_S10_cSCC | Human | Skin | cSCC | 2.40e-16 | 3.47e-01 | -0.299 |
55831 | EMC3 | P1_cSCC | Human | Skin | cSCC | 3.58e-38 | 1.16e+00 | 0.0292 |
55831 | EMC3 | P2_cSCC | Human | Skin | cSCC | 6.94e-14 | 5.33e-01 | -0.024 |
55831 | EMC3 | P4_cSCC | Human | Skin | cSCC | 1.07e-31 | 8.00e-01 | -0.00290000000000005 |
55831 | EMC3 | P10_cSCC | Human | Skin | cSCC | 3.41e-16 | 7.30e-01 | 0.1017 |
55831 | EMC3 | cSCC_p7 | Human | Skin | cSCC | 5.92e-03 | -1.49e-01 | -0.2332 |
55831 | EMC3 | cSCC_p8 | Human | Skin | cSCC | 1.05e-05 | 1.21e-01 | -0.1971 |
55831 | EMC3 | male-WTA | Human | Thyroid | PTC | 2.02e-43 | 9.44e-02 | 0.1037 |
55831 | EMC3 | PTC01 | Human | Thyroid | PTC | 1.99e-19 | 6.38e-01 | 0.1899 |
55831 | EMC3 | PTC04 | Human | Thyroid | PTC | 7.01e-06 | 3.00e-01 | 0.1927 |
55831 | EMC3 | PTC05 | Human | Thyroid | PTC | 2.47e-20 | 9.33e-01 | 0.2065 |
55831 | EMC3 | PTC06 | Human | Thyroid | PTC | 1.68e-23 | 8.17e-01 | 0.2057 |
55831 | EMC3 | PTC07 | Human | Thyroid | PTC | 1.60e-52 | 9.14e-01 | 0.2044 |
55831 | EMC3 | ATC11 | Human | Thyroid | ATC | 3.15e-10 | 5.24e-01 | 0.3386 |
55831 | EMC3 | ATC12 | Human | Thyroid | ATC | 4.67e-07 | 1.99e-01 | 0.34 |
55831 | EMC3 | ATC13 | Human | Thyroid | ATC | 4.57e-18 | 5.44e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
GO:0051205 | Colorectum | AD | protein insertion into membrane | 23/3918 | 57/18723 | 6.62e-04 | 6.80e-03 | 23 |
GO:0007029 | Colorectum | AD | endoplasmic reticulum organization | 31/3918 | 87/18723 | 1.08e-03 | 1.00e-02 | 31 |
GO:00901502 | Colorectum | MSS | establishment of protein localization to membrane | 90/3467 | 260/18723 | 4.11e-10 | 3.49e-08 | 90 |
GO:00512052 | Colorectum | MSS | protein insertion into membrane | 21/3467 | 57/18723 | 8.53e-04 | 8.75e-03 | 21 |
GO:00901504 | Colorectum | FAP | establishment of protein localization to membrane | 69/2622 | 260/18723 | 6.40e-08 | 4.54e-06 | 69 |
GO:0090150110 | Esophagus | ESCC | establishment of protein localization to membrane | 182/8552 | 260/18723 | 1.27e-15 | 8.19e-14 | 182 |
GO:000702914 | Esophagus | ESCC | endoplasmic reticulum organization | 65/8552 | 87/18723 | 3.28e-08 | 6.08e-07 | 65 |
GO:005120515 | Esophagus | ESCC | protein insertion into membrane | 46/8552 | 57/18723 | 5.90e-08 | 1.04e-06 | 46 |
GO:004504812 | Esophagus | ESCC | protein insertion into ER membrane | 21/8552 | 22/18723 | 8.75e-07 | 1.13e-05 | 21 |
GO:007181611 | Esophagus | ESCC | tail-anchored membrane protein insertion into ER membrane | 17/8552 | 17/18723 | 1.63e-06 | 1.95e-05 | 17 |
GO:00450503 | Esophagus | ESCC | protein insertion into ER membrane by stop-transfer membrane-anchor sequence | 10/8552 | 10/18723 | 3.94e-04 | 2.26e-03 | 10 |
GO:00901507 | Liver | Cirrhotic | establishment of protein localization to membrane | 123/4634 | 260/18723 | 1.85e-15 | 2.15e-13 | 123 |
GO:00070292 | Liver | Cirrhotic | endoplasmic reticulum organization | 42/4634 | 87/18723 | 1.67e-06 | 3.22e-05 | 42 |
GO:00512053 | Liver | Cirrhotic | protein insertion into membrane | 29/4634 | 57/18723 | 1.88e-05 | 2.53e-04 | 29 |
GO:0045048 | Liver | Cirrhotic | protein insertion into ER membrane | 11/4634 | 22/18723 | 9.18e-03 | 4.21e-02 | 11 |
GO:009015012 | Liver | HCC | establishment of protein localization to membrane | 168/7958 | 260/18723 | 4.07e-13 | 2.13e-11 | 168 |
GO:000702911 | Liver | HCC | endoplasmic reticulum organization | 64/7958 | 87/18723 | 3.92e-09 | 1.04e-07 | 64 |
GO:005120511 | Liver | HCC | protein insertion into membrane | 41/7958 | 57/18723 | 6.42e-06 | 7.83e-05 | 41 |
GO:0071816 | Liver | HCC | tail-anchored membrane protein insertion into ER membrane | 15/7958 | 17/18723 | 1.31e-04 | 1.07e-03 | 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EMC3 | SNV | Missense_Mutation | c.593N>C | p.Met198Thr | p.M198T | Q9P0I2 | protein_coding | tolerated(0.35) | benign(0) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
EMC3 | insertion | Frame_Shift_Ins | novel | c.271_272insA | p.Thr91AsnfsTer2 | p.T91Nfs*2 | Q9P0I2 | protein_coding | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
EMC3 | SNV | Missense_Mutation | c.538N>T | p.Arg180Trp | p.R180W | Q9P0I2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD | |
EMC3 | SNV | Missense_Mutation | novel | c.469N>A | p.Glu157Lys | p.E157K | Q9P0I2 | protein_coding | tolerated(0.07) | benign(0.432) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EMC3 | SNV | Missense_Mutation | rs761023207 | c.634N>A | p.Ala212Thr | p.A212T | Q9P0I2 | protein_coding | tolerated(0.34) | benign(0.037) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
EMC3 | SNV | Missense_Mutation | novel | c.260N>A | p.Phe87Tyr | p.F87Y | Q9P0I2 | protein_coding | tolerated(0.8) | benign(0.009) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
EMC3 | SNV | Missense_Mutation | c.323N>T | p.Thr108Ile | p.T108I | Q9P0I2 | protein_coding | deleterious(0.02) | benign(0.424) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EMC3 | SNV | Missense_Mutation | novel | c.459N>T | p.Gln153His | p.Q153H | Q9P0I2 | protein_coding | deleterious(0.04) | possibly_damaging(0.861) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EMC3 | SNV | Missense_Mutation | novel | c.296N>A | p.Ser99Tyr | p.S99Y | Q9P0I2 | protein_coding | deleterious(0) | possibly_damaging(0.808) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EMC3 | SNV | Missense_Mutation | novel | c.181C>T | p.Leu61Phe | p.L61F | Q9P0I2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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