![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: DNAJC8 |
Gene summary for DNAJC8 |
![]() |
Gene information | Species | Human | Gene symbol | DNAJC8 | Gene ID | 22826 |
Gene name | DnaJ heat shock protein family (Hsp40) member C8 | |
Gene Alias | HSPC331 | |
Cytomap | 1p35.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | O75937 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22826 | DNAJC8 | C57 | Human | Oral cavity | OSCC | 5.17e-18 | 1.00e+00 | 0.1679 |
22826 | DNAJC8 | C06 | Human | Oral cavity | OSCC | 1.64e-11 | 1.77e+00 | 0.2699 |
22826 | DNAJC8 | C07 | Human | Oral cavity | OSCC | 2.87e-05 | 1.26e+00 | 0.2491 |
22826 | DNAJC8 | C08 | Human | Oral cavity | OSCC | 3.49e-34 | 8.59e-01 | 0.1919 |
22826 | DNAJC8 | C09 | Human | Oral cavity | OSCC | 2.45e-08 | 4.93e-01 | 0.1431 |
22826 | DNAJC8 | LN22 | Human | Oral cavity | OSCC | 1.97e-09 | 1.48e+00 | 0.1733 |
22826 | DNAJC8 | LN46 | Human | Oral cavity | OSCC | 7.38e-13 | 9.82e-01 | 0.1666 |
22826 | DNAJC8 | LP15 | Human | Oral cavity | LP | 9.26e-05 | 1.26e+00 | 0.2174 |
22826 | DNAJC8 | LP17 | Human | Oral cavity | LP | 7.28e-11 | 1.53e+00 | 0.2349 |
22826 | DNAJC8 | SYSMH1 | Human | Oral cavity | OSCC | 1.29e-22 | 7.21e-01 | 0.1127 |
22826 | DNAJC8 | SYSMH2 | Human | Oral cavity | OSCC | 1.48e-36 | 1.45e+00 | 0.2326 |
22826 | DNAJC8 | SYSMH3 | Human | Oral cavity | OSCC | 5.82e-42 | 1.62e+00 | 0.2442 |
22826 | DNAJC8 | SYSMH4 | Human | Oral cavity | OSCC | 9.88e-05 | 2.17e-01 | 0.1226 |
22826 | DNAJC8 | SYSMH5 | Human | Oral cavity | OSCC | 1.90e-11 | 5.71e-01 | 0.0647 |
22826 | DNAJC8 | SYSMH6 | Human | Oral cavity | OSCC | 3.33e-07 | 5.85e-01 | 0.1275 |
22826 | DNAJC8 | GSM5252130_BPH340PrGF_Via | Human | Prostate | BPH | 2.76e-03 | 3.77e-01 | -0.1972 |
22826 | DNAJC8 | GSM5252132_BPH389PrGF | Human | Prostate | BPH | 1.74e-02 | 5.00e-01 | -0.2247 |
22826 | DNAJC8 | GSM5252133_BPH389PrSF | Human | Prostate | BPH | 1.86e-05 | 6.75e-01 | -0.2027 |
22826 | DNAJC8 | GSM5252137_BPH556PrGA2_Fcol | Human | Prostate | BPH | 2.90e-02 | 3.37e-01 | -0.23 |
22826 | DNAJC8 | 047563_1562-all-cells | Human | Prostate | BPH | 6.27e-26 | -2.88e-01 | 0.0791 |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DNAJC8 | insertion | In_Frame_Ins | novel | c.23_24insAGTTTTGCTCTTGTTGCCCAGGCCTGGAGTGCA | p.Gly8_Thr9insValLeuLeuLeuLeuProArgProGlyValGln | p.G8_T9insVLLLLPRPGVQ | O75937 | protein_coding | TCGA-B6-A0I6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
DNAJC8 | SNV | Missense_Mutation | c.126N>C | p.Gln42His | p.Q42H | O75937 | protein_coding | deleterious(0.02) | benign(0.183) | TCGA-C5-A1BK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
DNAJC8 | SNV | Missense_Mutation | c.583N>A | p.Glu195Lys | p.E195K | O75937 | protein_coding | tolerated(0.05) | possibly_damaging(0.614) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
DNAJC8 | SNV | Missense_Mutation | c.583N>A | p.Glu195Lys | p.E195K | O75937 | protein_coding | tolerated(0.05) | possibly_damaging(0.614) | TCGA-C5-A3HL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
DNAJC8 | SNV | Missense_Mutation | novel | c.76N>A | p.Glu26Lys | p.E26K | O75937 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
DNAJC8 | insertion | In_Frame_Ins | novel | c.655_656insTAT | p.Arg219delinsLeuCys | p.R219delinsLC | O75937 | protein_coding | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | ||
DNAJC8 | SNV | Missense_Mutation | c.643N>C | p.Ser215Arg | p.S215R | O75937 | protein_coding | deleterious(0) | possibly_damaging(0.526) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
DNAJC8 | SNV | Missense_Mutation | novel | c.263N>C | p.Lys88Thr | p.K88T | O75937 | protein_coding | deleterious(0.02) | probably_damaging(0.987) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
DNAJC8 | SNV | Missense_Mutation | c.20G>A | p.Ser7Asn | p.S7N | O75937 | protein_coding | tolerated(0.17) | benign(0.015) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
DNAJC8 | SNV | Missense_Mutation | c.228N>C | p.Arg76Ser | p.R76S | O75937 | protein_coding | deleterious(0.01) | benign(0.324) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |