Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: DCTN1

Gene summary for DCTN1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

DCTN1

Gene ID

1639

Gene namedynactin subunit 1
Gene AliasDAP-150
Cytomap2p13.1
Gene Typeprotein-coding
GO ID

GO:0000132

UniProtAcc

Q14203


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
1639DCTN1P1_cSCCHumanSkincSCC2.34e-216.85e-010.0292
1639DCTN1P2_cSCCHumanSkincSCC1.30e-073.36e-01-0.024
1639DCTN1P4_cSCCHumanSkincSCC5.81e-052.84e-01-0.00290000000000005
1639DCTN1P10_cSCCHumanSkincSCC1.06e-165.37e-010.1017
1639DCTN1male-WTAHumanThyroidPTC4.63e-282.95e-010.1037
1639DCTN1PTC01HumanThyroidPTC1.06e-051.00e-010.1899
1639DCTN1PTC04HumanThyroidPTC3.77e-111.92e-010.1927
1639DCTN1PTC05HumanThyroidPTC1.15e-165.32e-010.2065
1639DCTN1PTC06HumanThyroidPTC4.43e-315.72e-010.2057
1639DCTN1PTC07HumanThyroidPTC1.28e-223.94e-010.2044
1639DCTN1ATC09HumanThyroidATC2.09e-031.33e-010.2871
1639DCTN1ATC11HumanThyroidATC7.21e-065.88e-010.3386
1639DCTN1ATC12HumanThyroidATC1.15e-265.55e-010.34
1639DCTN1ATC13HumanThyroidATC8.28e-285.61e-010.34
1639DCTN1ATC1HumanThyroidATC8.50e-061.93e-010.2878
1639DCTN1ATC2HumanThyroidATC3.03e-241.43e+000.34
1639DCTN1ATC3HumanThyroidATC1.95e-116.48e-010.338
1639DCTN1ATC4HumanThyroidATC2.67e-376.83e-010.34
1639DCTN1ATC5HumanThyroidATC5.55e-346.19e-010.34
Page: 1 2 3 4 5 6 7 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:1902903ColorectumADregulation of supramolecular fiber organization139/3918383/187232.01e-123.19e-10139
GO:0032271ColorectumADregulation of protein polymerization94/3918233/187231.01e-111.29e-0994
GO:0051258ColorectumADprotein polymerization112/3918297/187231.85e-112.27e-09112
GO:0043254ColorectumADregulation of protein-containing complex assembly148/3918428/187232.64e-113.18e-09148
GO:1902905ColorectumADpositive regulation of supramolecular fiber organization85/3918209/187235.95e-116.33e-0985
GO:0051495ColorectumADpositive regulation of cytoskeleton organization89/3918226/187231.61e-101.56e-0889
GO:0016197ColorectumADendosomal transport90/3918230/187231.88e-101.73e-0890
GO:0032273ColorectumADpositive regulation of protein polymerization62/3918138/187231.94e-101.76e-0862
GO:0031334ColorectumADpositive regulation of protein-containing complex assembly91/3918237/187234.78e-103.99e-0891
GO:0022411ColorectumADcellular component disassembly147/3918443/187238.53e-106.76e-08147
GO:0051656ColorectumADestablishment of organelle localization131/3918390/187233.00e-092.06e-07131
GO:0016482ColorectumADcytosolic transport68/3918168/187236.00e-093.72e-0768
GO:0007163ColorectumADestablishment or maintenance of cell polarity77/3918218/187235.72e-072.08e-0577
GO:0042147ColorectumADretrograde transport, endosome to Golgi37/391891/187231.46e-053.14e-0437
GO:0106027ColorectumADneuron projection organization36/391893/187236.58e-051.07e-0336
GO:0030010ColorectumADestablishment of cell polarity50/3918143/187236.90e-051.11e-0350
GO:0060249ColorectumADanatomical structure homeostasis94/3918314/187239.37e-051.42e-0394
GO:0043954ColorectumADcellular component maintenance26/391861/187231.04e-041.56e-0326
GO:0007051ColorectumADspindle organization58/3918184/187234.71e-045.20e-0358
GO:1902850ColorectumADmicrotubule cytoskeleton organization involved in mitosis48/3918147/187235.87e-046.21e-0348
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa05016ColorectumADHuntington disease147/2092306/84651.93e-199.26e-185.91e-18147
hsa05014ColorectumADAmyotrophic lateral sclerosis164/2092364/84654.28e-181.27e-168.09e-17164
hsa05022ColorectumADPathways of neurodegeneration - multiple diseases201/2092476/84654.54e-181.27e-168.09e-17201
hsa05132ColorectumADSalmonella infection102/2092249/84657.65e-091.28e-078.17e-08102
hsa04962ColorectumADVasopressin-regulated water reabsorption19/209244/84655.48e-032.48e-021.58e-0219
hsa050161ColorectumADHuntington disease147/2092306/84651.93e-199.26e-185.91e-18147
hsa050141ColorectumADAmyotrophic lateral sclerosis164/2092364/84654.28e-181.27e-168.09e-17164
hsa050221ColorectumADPathways of neurodegeneration - multiple diseases201/2092476/84654.54e-181.27e-168.09e-17201
hsa051321ColorectumADSalmonella infection102/2092249/84657.65e-091.28e-078.17e-08102
hsa049621ColorectumADVasopressin-regulated water reabsorption19/209244/84655.48e-032.48e-021.58e-0219
hsa050162ColorectumSERHuntington disease127/1580306/84653.29e-211.37e-199.92e-20127
hsa050222ColorectumSERPathways of neurodegeneration - multiple diseases168/1580476/84656.23e-192.07e-171.50e-17168
hsa050142ColorectumSERAmyotrophic lateral sclerosis138/1580364/84659.89e-192.99e-172.17e-17138
hsa051322ColorectumSERSalmonella infection77/1580249/84651.56e-062.35e-051.71e-0577
hsa050163ColorectumSERHuntington disease127/1580306/84653.29e-211.37e-199.92e-20127
hsa050223ColorectumSERPathways of neurodegeneration - multiple diseases168/1580476/84656.23e-192.07e-171.50e-17168
hsa050143ColorectumSERAmyotrophic lateral sclerosis138/1580364/84659.89e-192.99e-172.17e-17138
hsa051323ColorectumSERSalmonella infection77/1580249/84651.56e-062.35e-051.71e-0577
hsa050164ColorectumMSSHuntington disease141/1875306/84652.90e-211.62e-199.92e-20141
hsa050224ColorectumMSSPathways of neurodegeneration - multiple diseases192/1875476/84652.79e-201.04e-186.36e-19192
Page: 1 2 3 4 5 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
DCTN1SNVMissense_Mutationnovelc.2262G>Cp.Gln754Hisp.Q754HQ14203protein_codingtolerated(0.13)probably_damaging(0.992)TCGA-5L-AAT1-01Breastbreast invasive carcinomaFemale<65III/IVHormone TherapyletrozolSD
DCTN1SNVMissense_Mutationrs761071126c.1748G>Ap.Arg583Glnp.R583QQ14203protein_codingtolerated(0.27)probably_damaging(0.988)TCGA-5L-AAT1-01Breastbreast invasive carcinomaFemale<65III/IVHormone TherapyletrozolSD
DCTN1SNVMissense_Mutationnovelc.1492G>Ap.Glu498Lysp.E498KQ14203protein_codingdeleterious(0.01)probably_damaging(0.971)TCGA-5L-AAT1-01Breastbreast invasive carcinomaFemale<65III/IVHormone TherapyletrozolSD
DCTN1SNVMissense_Mutationrs146083590c.3799N>Cp.Glu1267Glnp.E1267QQ14203protein_codingtolerated(0.51)benign(0.037)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
DCTN1SNVMissense_Mutationrs755766984c.3788N>Gp.Val1263Glyp.V1263GQ14203protein_codingtolerated(0.1)benign(0.42)TCGA-B6-A0RN-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
DCTN1SNVMissense_Mutationrs145293019c.2518N>Ap.Val840Metp.V840MQ14203protein_codingdeleterious(0.01)possibly_damaging(0.598)TCGA-BH-A0HF-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
DCTN1SNVMissense_Mutationrs376549770c.3497N>Tp.Thr1166Metp.T1166MQ14203protein_codingtolerated(0.11)benign(0.116)TCGA-D8-A1XQ-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
DCTN1SNVMissense_Mutationrs766620798c.1850N>Ap.Cys617Tyrp.C617YQ14203protein_codingtolerated(0.08)probably_damaging(0.995)TCGA-EW-A1P0-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapyarimidexPD
DCTN1insertionNonsense_Mutationnovelc.3144_3145insTTGGGGCTTGTGTTTTGACCTTTGTCTAGp.Arg1049LeufsTer6p.R1049Lfs*6Q14203protein_codingTCGA-A8-A09E-01Breastbreast invasive carcinomaFemale>=65III/IVHormone TherapyanastrozoleSD
DCTN1insertionNonsense_Mutationnovelc.1305_1306insCACAACCTCCAGTAATCACATCACTACCCTTTCCCCAp.Ala436HisfsTer5p.A436Hfs*5Q14203protein_codingTCGA-AO-A0JB-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycyclophosphamideSD
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1