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Gene: CUEDC2 |
Gene summary for CUEDC2 |
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Gene information | Species | Human | Gene symbol | CUEDC2 | Gene ID | 79004 |
Gene name | CUE domain containing 2 | |
Gene Alias | C10orf66 | |
Cytomap | 10q24.32 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | Q9H467 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79004 | CUEDC2 | ATC3 | Human | Thyroid | ATC | 6.39e-09 | 3.40e-01 | 0.338 |
79004 | CUEDC2 | ATC4 | Human | Thyroid | ATC | 2.32e-24 | 5.67e-01 | 0.34 |
79004 | CUEDC2 | ATC5 | Human | Thyroid | ATC | 2.49e-42 | 7.43e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000268316 | Esophagus | ESCC | negative regulation of immune system process | 231/8552 | 434/18723 | 8.48e-04 | 4.36e-03 | 231 |
GO:000268310 | Oral cavity | OSCC | negative regulation of immune system process | 204/7305 | 434/18723 | 3.72e-04 | 2.27e-03 | 204 |
GO:000268315 | Oral cavity | LP | negative regulation of immune system process | 130/4623 | 434/18723 | 6.70e-03 | 3.90e-02 | 130 |
GO:00026839 | Prostate | BPH | negative regulation of immune system process | 100/3107 | 434/18723 | 2.83e-04 | 2.20e-03 | 100 |
GO:000268314 | Prostate | Tumor | negative regulation of immune system process | 101/3246 | 434/18723 | 8.70e-04 | 5.85e-03 | 101 |
GO:0061082 | Thyroid | ATC | myeloid leukocyte cytokine production | 18/6293 | 28/18723 | 8.70e-04 | 4.72e-03 | 18 |
GO:0010934 | Thyroid | ATC | macrophage cytokine production | 12/6293 | 17/18723 | 2.02e-03 | 9.60e-03 | 12 |
GO:0010935 | Thyroid | ATC | regulation of macrophage cytokine production | 12/6293 | 17/18723 | 2.02e-03 | 9.60e-03 | 12 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CUEDC2 | insertion | Nonsense_Mutation | novel | c.246_247insTAAATAATTCGTTTAAAATCATAAAAC | p.Lys82_Leu83insTer | p.K82_L83ins* | Q9H467 | protein_coding | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
CUEDC2 | deletion | Frame_Shift_Del | novel | c.355delA | p.Met119CysfsTer65 | p.M119Cfs*65 | Q9H467 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
CUEDC2 | SNV | Missense_Mutation | c.755N>C | p.Val252Ala | p.V252A | Q9H467 | protein_coding | deleterious(0) | benign(0.283) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
CUEDC2 | SNV | Missense_Mutation | c.818N>T | p.Ala273Val | p.A273V | Q9H467 | protein_coding | deleterious(0.02) | benign(0.236) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CUEDC2 | SNV | Missense_Mutation | rs767718515 | c.157N>A | p.Asp53Asn | p.D53N | Q9H467 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CUEDC2 | SNV | Missense_Mutation | c.818N>G | p.Ala273Gly | p.A273G | Q9H467 | protein_coding | deleterious(0.03) | benign(0.095) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CUEDC2 | SNV | Missense_Mutation | rs778175495 | c.745N>A | p.Asp249Asn | p.D249N | Q9H467 | protein_coding | tolerated(0.28) | possibly_damaging(0.694) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
CUEDC2 | SNV | Missense_Mutation | rs773939359 | c.352N>A | p.Glu118Lys | p.E118K | Q9H467 | protein_coding | tolerated(0.13) | benign(0.028) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
CUEDC2 | SNV | Missense_Mutation | novel | c.802N>A | p.Ala268Thr | p.A268T | Q9H467 | protein_coding | tolerated(0.85) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CUEDC2 | SNV | Missense_Mutation | novel | c.233N>G | p.Asp78Gly | p.D78G | Q9H467 | protein_coding | deleterious(0) | possibly_damaging(0.703) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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