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Gene: CENPB |
Gene summary for CENPB |
Gene summary. |
Gene information | Species | Human | Gene symbol | CENPB | Gene ID | 1059 |
Gene name | centromere protein B | |
Gene Alias | CENPB | |
Cytomap | 20p13 | |
Gene Type | protein-coding | GO ID | GO:0000775 | UniProtAcc | P07199 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1059 | CENPB | cSCC_p11 | Human | Skin | cSCC | 1.81e-07 | 1.93e-01 | -0.2102 |
1059 | CENPB | cSCC_p3 | Human | Skin | cSCC | 6.40e-04 | 1.86e-01 | -0.2085 |
1059 | CENPB | cSCC_p8 | Human | Skin | cSCC | 4.10e-07 | 1.80e-01 | -0.1971 |
1059 | CENPB | cSCC_p9 | Human | Skin | cSCC | 1.83e-04 | 1.13e-01 | -0.1991 |
1059 | CENPB | male-WTA | Human | Thyroid | PTC | 1.02e-31 | 3.56e-01 | 0.1037 |
1059 | CENPB | PTC01 | Human | Thyroid | PTC | 5.59e-07 | 6.53e-02 | 0.1899 |
1059 | CENPB | PTC04 | Human | Thyroid | PTC | 1.03e-16 | 2.77e-01 | 0.1927 |
1059 | CENPB | PTC05 | Human | Thyroid | PTC | 1.75e-27 | 7.13e-01 | 0.2065 |
1059 | CENPB | PTC06 | Human | Thyroid | PTC | 1.20e-30 | 6.12e-01 | 0.2057 |
1059 | CENPB | PTC07 | Human | Thyroid | PTC | 2.77e-19 | 4.35e-01 | 0.2044 |
1059 | CENPB | ATC09 | Human | Thyroid | ATC | 7.52e-05 | 2.12e-01 | 0.2871 |
1059 | CENPB | ATC12 | Human | Thyroid | ATC | 8.21e-25 | 5.80e-01 | 0.34 |
1059 | CENPB | ATC13 | Human | Thyroid | ATC | 1.28e-16 | 3.14e-01 | 0.34 |
1059 | CENPB | ATC1 | Human | Thyroid | ATC | 4.79e-05 | 2.38e-01 | 0.2878 |
1059 | CENPB | ATC2 | Human | Thyroid | ATC | 4.61e-17 | 1.07e+00 | 0.34 |
1059 | CENPB | ATC3 | Human | Thyroid | ATC | 1.39e-07 | 4.04e-01 | 0.338 |
1059 | CENPB | ATC4 | Human | Thyroid | ATC | 1.97e-33 | 7.24e-01 | 0.34 |
1059 | CENPB | ATC5 | Human | Thyroid | ATC | 7.72e-19 | 3.61e-01 | 0.34 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
CENPB | PARI | Stomach | Healthy | YTHDF3,NBL1,RRM2, etc. | 2.68e-02 |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CENPB | SNV | Missense_Mutation | novel | c.1543N>A | p.Glu515Lys | p.E515K | P07199 | protein_coding | deleterious_low_confidence(0.02) | benign(0.052) | TCGA-E2-A14P-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Targeted Molecular therapy | trastuzumab | SD |
CENPB | deletion | Frame_Shift_Del | novel | c.814delN | p.Gln272ArgfsTer7 | p.Q272Rfs*7 | P07199 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
CENPB | SNV | Missense_Mutation | novel | c.1612N>C | p.Glu538Gln | p.E538Q | P07199 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.992) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
CENPB | SNV | Missense_Mutation | novel | c.1369N>T | p.Asp457Tyr | p.D457Y | P07199 | protein_coding | tolerated_low_confidence(0.05) | benign(0.261) | TCGA-ZJ-AAXB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CENPB | deletion | In_Frame_Del | rs754367212 | c.1242_1256delAGAGGAGGAGGAAGA | p.Glu415_Glu419del | p.E415_E419del | P07199 | protein_coding | TCGA-EK-A3GM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CENPB | SNV | Missense_Mutation | novel | c.869N>A | p.Arg290His | p.R290H | P07199 | protein_coding | deleterious(0) | probably_damaging(0.957) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CENPB | SNV | Missense_Mutation | novel | c.311C>T | p.Ala104Val | p.A104V | P07199 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CENPB | SNV | Missense_Mutation | c.1130N>T | p.Pro377Leu | p.P377L | P07199 | protein_coding | deleterious(0.03) | possibly_damaging(0.83) | TCGA-AG-3881-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CENPB | SNV | Missense_Mutation | rs765081320 | c.1585G>A | p.Asp529Asn | p.D529N | P07199 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.57) | TCGA-AG-3902-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CENPB | deletion | Frame_Shift_Del | rs772292203 | c.1312delN | p.Glu438LysfsTer43 | p.E438Kfs*43 | P07199 | protein_coding | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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