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Gene: CCT6A |
Gene summary for CCT6A |
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Gene information | Species | Human | Gene symbol | CCT6A | Gene ID | 908 |
Gene name | chaperonin containing TCP1 subunit 6A | |
Gene Alias | CCT-zeta | |
Cytomap | 7p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000723 | UniProtAcc | P40227 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
908 | CCT6A | C04 | Human | Oral cavity | OSCC | 2.10e-35 | 2.43e+00 | 0.2633 |
908 | CCT6A | C21 | Human | Oral cavity | OSCC | 1.50e-63 | 3.18e+00 | 0.2678 |
908 | CCT6A | C30 | Human | Oral cavity | OSCC | 1.71e-49 | 3.88e+00 | 0.3055 |
908 | CCT6A | C38 | Human | Oral cavity | OSCC | 6.76e-23 | 2.39e+00 | 0.172 |
908 | CCT6A | C43 | Human | Oral cavity | OSCC | 2.39e-81 | 1.67e+00 | 0.1704 |
908 | CCT6A | C46 | Human | Oral cavity | OSCC | 3.31e-66 | 1.67e+00 | 0.1673 |
908 | CCT6A | C51 | Human | Oral cavity | OSCC | 2.56e-26 | 1.87e+00 | 0.2674 |
908 | CCT6A | C57 | Human | Oral cavity | OSCC | 9.79e-21 | 1.27e+00 | 0.1679 |
908 | CCT6A | C06 | Human | Oral cavity | OSCC | 1.11e-16 | 2.67e+00 | 0.2699 |
908 | CCT6A | C07 | Human | Oral cavity | OSCC | 2.13e-03 | 1.23e+00 | 0.2491 |
908 | CCT6A | C08 | Human | Oral cavity | OSCC | 6.84e-69 | 1.90e+00 | 0.1919 |
908 | CCT6A | C09 | Human | Oral cavity | OSCC | 4.95e-12 | 6.67e-01 | 0.1431 |
908 | CCT6A | LN22 | Human | Oral cavity | OSCC | 2.05e-10 | 1.47e+00 | 0.1733 |
908 | CCT6A | LN38 | Human | Oral cavity | OSCC | 5.67e-09 | 1.87e+00 | 0.168 |
908 | CCT6A | LN46 | Human | Oral cavity | OSCC | 1.95e-27 | 1.43e+00 | 0.1666 |
908 | CCT6A | LP15 | Human | Oral cavity | LP | 1.98e-15 | 2.00e+00 | 0.2174 |
908 | CCT6A | LP17 | Human | Oral cavity | LP | 3.39e-09 | 1.54e+00 | 0.2349 |
908 | CCT6A | SYSMH1 | Human | Oral cavity | OSCC | 1.61e-28 | 9.01e-01 | 0.1127 |
908 | CCT6A | SYSMH2 | Human | Oral cavity | OSCC | 2.52e-40 | 1.75e+00 | 0.2326 |
908 | CCT6A | SYSMH3 | Human | Oral cavity | OSCC | 2.32e-51 | 1.86e+00 | 0.2442 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1903829 | Colorectum | AD | positive regulation of cellular protein localization | 110/3918 | 276/18723 | 4.58e-13 | 8.44e-11 | 110 |
GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
GO:0031647 | Colorectum | AD | regulation of protein stability | 108/3918 | 298/18723 | 6.33e-10 | 5.08e-08 | 108 |
GO:1904951 | Colorectum | AD | positive regulation of establishment of protein localization | 112/3918 | 319/18723 | 2.55e-09 | 1.80e-07 | 112 |
GO:0050821 | Colorectum | AD | protein stabilization | 73/3918 | 191/18723 | 3.02e-08 | 1.64e-06 | 73 |
GO:1900180 | Colorectum | AD | regulation of protein localization to nucleus | 55/3918 | 136/18723 | 1.70e-07 | 7.34e-06 | 55 |
GO:0051052 | Colorectum | AD | regulation of DNA metabolic process | 116/3918 | 359/18723 | 2.47e-07 | 1.00e-05 | 116 |
GO:0051054 | Colorectum | AD | positive regulation of DNA metabolic process | 73/3918 | 201/18723 | 3.27e-07 | 1.29e-05 | 73 |
GO:1900182 | Colorectum | AD | positive regulation of protein localization to nucleus | 38/3918 | 87/18723 | 1.43e-06 | 4.52e-05 | 38 |
GO:0006403 | Colorectum | AD | RNA localization | 71/3918 | 201/18723 | 1.54e-06 | 4.76e-05 | 71 |
GO:0034504 | Colorectum | AD | protein localization to nucleus | 94/3918 | 290/18723 | 2.83e-06 | 8.09e-05 | 94 |
GO:0006457 | Colorectum | AD | protein folding | 73/3918 | 212/18723 | 3.24e-06 | 9.10e-05 | 73 |
GO:2001252 | Colorectum | AD | positive regulation of chromosome organization | 35/3918 | 82/18723 | 6.90e-06 | 1.72e-04 | 35 |
GO:2000278 | Colorectum | AD | regulation of DNA biosynthetic process | 41/3918 | 106/18723 | 2.17e-05 | 4.33e-04 | 41 |
GO:2000573 | Colorectum | AD | positive regulation of DNA biosynthetic process | 28/3918 | 66/18723 | 6.35e-05 | 1.05e-03 | 28 |
GO:0032206 | Colorectum | AD | positive regulation of telomere maintenance | 23/3918 | 52/18723 | 1.31e-04 | 1.88e-03 | 23 |
GO:0032204 | Colorectum | AD | regulation of telomere maintenance | 31/3918 | 80/18723 | 2.01e-04 | 2.67e-03 | 31 |
GO:0033044 | Colorectum | AD | regulation of chromosome organization | 60/3918 | 187/18723 | 2.25e-04 | 2.94e-03 | 60 |
GO:0000723 | Colorectum | AD | telomere maintenance | 43/3918 | 131/18723 | 9.77e-04 | 9.20e-03 | 43 |
GO:0010833 | Colorectum | AD | telomere maintenance via telomere lengthening | 29/3918 | 81/18723 | 1.42e-03 | 1.22e-02 | 29 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCT6A | SNV | Missense_Mutation | rs770231271 | c.1324N>A | p.Asp442Asn | p.D442N | P40227 | protein_coding | tolerated(0.2) | benign(0.012) | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCT6A | SNV | Missense_Mutation | c.1115N>C | p.Val372Ala | p.V372A | P40227 | protein_coding | tolerated(0.07) | possibly_damaging(0.588) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CCT6A | SNV | Missense_Mutation | novel | c.867N>A | p.Phe289Leu | p.F289L | P40227 | protein_coding | deleterious(0.04) | possibly_damaging(0.85) | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD |
CCT6A | SNV | Missense_Mutation | novel | c.559N>A | p.Asp187Asn | p.D187N | P40227 | protein_coding | tolerated(0.06) | possibly_damaging(0.558) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CCT6A | insertion | In_Frame_Ins | novel | c.869_870insCCTAAGATTTAACAG | p.Val290_Val291insLeuArgPheAsnSer | p.V290_V291insLRFNS | P40227 | protein_coding | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | ||
CCT6A | SNV | Missense_Mutation | c.1268N>A | p.Ile423Asn | p.I423N | P40227 | protein_coding | tolerated(0.36) | benign(0.005) | TCGA-A6-6649-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | SD | |
CCT6A | SNV | Missense_Mutation | c.464N>A | p.Ser155Tyr | p.S155Y | P40227 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CCT6A | SNV | Missense_Mutation | c.650G>A | p.Arg217Gln | p.R217Q | P40227 | protein_coding | deleterious(0.03) | possibly_damaging(0.884) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
CCT6A | SNV | Missense_Mutation | c.1240N>A | p.Val414Met | p.V414M | P40227 | protein_coding | deleterious(0) | possibly_damaging(0.556) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CCT6A | SNV | Missense_Mutation | c.1310T>C | p.Val437Ala | p.V437A | P40227 | protein_coding | deleterious(0.03) | benign(0.158) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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