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Gene: CA12 |
Gene summary for CA12 |
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Gene information | Species | Human | Gene symbol | CA12 | Gene ID | 771 |
Gene name | carbonic anhydrase 12 | |
Gene Alias | CA-XII | |
Cytomap | 15q22.2 | |
Gene Type | protein-coding | GO ID | GO:0006730 | UniProtAcc | O43570 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
771 | CA12 | P21T-E | Human | Esophagus | ESCC | 1.81e-23 | 8.34e-01 | 0.1617 |
771 | CA12 | P22T-E | Human | Esophagus | ESCC | 2.07e-22 | 6.11e-01 | 0.1236 |
771 | CA12 | P26T-E | Human | Esophagus | ESCC | 4.77e-12 | 6.55e-01 | 0.1276 |
771 | CA12 | P27T-E | Human | Esophagus | ESCC | 1.17e-13 | 5.98e-01 | 0.1055 |
771 | CA12 | P28T-E | Human | Esophagus | ESCC | 4.18e-42 | 1.16e+00 | 0.1149 |
771 | CA12 | P30T-E | Human | Esophagus | ESCC | 1.97e-34 | 2.06e+00 | 0.137 |
771 | CA12 | P31T-E | Human | Esophagus | ESCC | 3.06e-06 | -2.07e-01 | 0.1251 |
771 | CA12 | P32T-E | Human | Esophagus | ESCC | 1.82e-18 | 9.28e-01 | 0.1666 |
771 | CA12 | P37T-E | Human | Esophagus | ESCC | 4.42e-21 | 1.17e+00 | 0.1371 |
771 | CA12 | P38T-E | Human | Esophagus | ESCC | 2.82e-06 | -2.15e-01 | 0.127 |
771 | CA12 | P39T-E | Human | Esophagus | ESCC | 1.95e-02 | 2.09e-01 | 0.0894 |
771 | CA12 | P42T-E | Human | Esophagus | ESCC | 3.95e-13 | 1.14e+00 | 0.1175 |
771 | CA12 | P44T-E | Human | Esophagus | ESCC | 2.44e-03 | 3.41e-01 | 0.1096 |
771 | CA12 | P47T-E | Human | Esophagus | ESCC | 6.51e-08 | 4.50e-01 | 0.1067 |
771 | CA12 | P48T-E | Human | Esophagus | ESCC | 4.00e-23 | 8.42e-01 | 0.0959 |
771 | CA12 | P49T-E | Human | Esophagus | ESCC | 1.31e-13 | 2.65e+00 | 0.1768 |
771 | CA12 | P52T-E | Human | Esophagus | ESCC | 2.30e-41 | 1.38e+00 | 0.1555 |
771 | CA12 | P54T-E | Human | Esophagus | ESCC | 1.28e-07 | 7.74e-01 | 0.0975 |
771 | CA12 | P56T-E | Human | Esophagus | ESCC | 4.45e-02 | 4.39e-01 | 0.1613 |
771 | CA12 | P62T-E | Human | Esophagus | ESCC | 2.47e-64 | 1.91e+00 | 0.1302 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006730 | Colorectum | AD | one-carbon metabolic process | 18/3918 | 40/18723 | 5.36e-04 | 5.74e-03 | 18 |
GO:00067301 | Colorectum | SER | one-carbon metabolic process | 15/2897 | 40/18723 | 5.71e-04 | 7.86e-03 | 15 |
GO:00067302 | Colorectum | MSS | one-carbon metabolic process | 15/3467 | 40/18723 | 3.72e-03 | 2.73e-02 | 15 |
GO:0048875 | Lung | IAC | chemical homeostasis within a tissue | 11/2061 | 14/18723 | 7.44e-09 | 1.05e-06 | 11 |
GO:0043129 | Lung | IAC | surfactant homeostasis | 10/2061 | 12/18723 | 1.37e-08 | 1.77e-06 | 10 |
GO:00020648 | Lung | IAC | epithelial cell development | 52/2061 | 220/18723 | 6.75e-08 | 6.91e-06 | 52 |
GO:00726598 | Lung | IAC | protein localization to plasma membrane | 60/2061 | 284/18723 | 4.74e-07 | 3.10e-05 | 60 |
GO:19907787 | Lung | IAC | protein localization to cell periphery | 66/2061 | 333/18723 | 1.44e-06 | 7.22e-05 | 66 |
GO:00308562 | Lung | IAC | regulation of epithelial cell differentiation | 34/2061 | 154/18723 | 5.40e-05 | 1.21e-03 | 34 |
GO:00224078 | Lung | IAC | regulation of cell-cell adhesion | 76/2061 | 448/18723 | 8.16e-05 | 1.68e-03 | 76 |
GO:0045616 | Lung | IAC | regulation of keratinocyte differentiation | 13/2061 | 37/18723 | 9.33e-05 | 1.87e-03 | 13 |
GO:00323867 | Lung | IAC | regulation of intracellular transport | 60/2061 | 337/18723 | 1.16e-04 | 2.22e-03 | 60 |
GO:00435882 | Lung | IAC | skin development | 49/2061 | 263/18723 | 1.56e-04 | 2.82e-03 | 49 |
GO:0045604 | Lung | IAC | regulation of epidermal cell differentiation | 16/2061 | 58/18723 | 3.85e-04 | 5.87e-03 | 16 |
GO:00097438 | Lung | IAC | response to carbohydrate | 46/2061 | 253/18723 | 4.28e-04 | 6.37e-03 | 46 |
GO:0045682 | Lung | IAC | regulation of epidermis development | 17/2061 | 65/18723 | 5.07e-04 | 7.33e-03 | 17 |
GO:00099135 | Lung | IAC | epidermal cell differentiation | 37/2061 | 202/18723 | 1.29e-03 | 1.45e-02 | 37 |
GO:00323887 | Lung | IAC | positive regulation of intracellular transport | 37/2061 | 202/18723 | 1.29e-03 | 1.45e-02 | 37 |
GO:00018947 | Lung | IAC | tissue homeostasis | 46/2061 | 268/18723 | 1.50e-03 | 1.60e-02 | 46 |
GO:0030216 | Lung | IAC | keratinocyte differentiation | 27/2061 | 139/18723 | 2.34e-03 | 2.28e-02 | 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CA12 | SNV | Missense_Mutation | c.65C>T | p.Ser22Phe | p.S22F | O43570 | protein_coding | tolerated(0.07) | possibly_damaging(0.707) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CA12 | deletion | Frame_Shift_Del | novel | c.34_49delCTCCTGCTGGTGATCT | p.Leu12Ter | p.L12* | O43570 | protein_coding | TCGA-LL-A5YP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
CA12 | SNV | Missense_Mutation | c.358N>A | p.Leu120Met | p.L120M | O43570 | protein_coding | tolerated(0.16) | possibly_damaging(0.775) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CA12 | SNV | Missense_Mutation | novel | c.421N>A | p.Ala141Thr | p.A141T | O43570 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CA12 | SNV | Missense_Mutation | c.542N>T | p.Pro181Leu | p.P181L | O43570 | protein_coding | deleterious(0) | possibly_damaging(0.834) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CA12 | SNV | Missense_Mutation | novel | c.977N>C | p.Leu326Pro | p.L326P | O43570 | protein_coding | deleterious(0) | probably_damaging(0.936) | TCGA-AZ-6603-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CA12 | SNV | Missense_Mutation | c.485A>G | p.Asn162Ser | p.N162S | O43570 | protein_coding | deleterious(0.01) | benign(0.007) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CA12 | SNV | Missense_Mutation | rs769313979 | c.658N>T | p.Arg220Cys | p.R220C | O43570 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CA12 | SNV | Missense_Mutation | novel | c.431N>C | p.Leu144Pro | p.L144P | O43570 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CA12 | SNV | Missense_Mutation | novel | c.239A>C | p.Asn80Thr | p.N80T | O43570 | protein_coding | deleterious(0) | benign(0.243) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
771 | CA12 | DRUGGABLE GENOME | Salicyclic acid | |||
771 | CA12 | DRUGGABLE GENOME | celecoxib | CELECOXIB | 22336956 | |
771 | CA12 | DRUGGABLE GENOME | inhibitor | CHEMBL1200814 | ACETAZOLAMIDE SODIUM | |
771 | CA12 | DRUGGABLE GENOME | COUMATE | |||
771 | CA12 | DRUGGABLE GENOME | Curcumin | CURCUMIN | ||
771 | CA12 | DRUGGABLE GENOME | FERULIC ACID | |||
771 | CA12 | DRUGGABLE GENOME | PARABEN | PARABEN | ||
771 | CA12 | DRUGGABLE GENOME | ACETAZOLAMIDE | ACETAZOLAMIDE | ||
771 | CA12 | DRUGGABLE GENOME | zonisamide | ZONISAMIDE | 21278619 | |
771 | CA12 | DRUGGABLE GENOME | ACETAZOLAMIDE | ACETAZOLAMIDE |
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