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Gene: C7orf73 |
Gene summary for C7ORF73 |
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Gene information | Species | Human | Gene symbol | C7orf73 | Gene ID | 647087 |
Gene name | short transmembrane mitochondrial protein 1 | |
Gene Alias | C7orf73 | |
Cytomap | 7q33 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | E0CX11 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
647087 | C7orf73 | NEOLP-3 | Human | Oral cavity | NEOLP | 2.01e-07 | -2.62e-01 | -0.0191 |
647087 | C7orf73 | SYSMH1 | Human | Oral cavity | OSCC | 2.29e-42 | 1.04e+00 | 0.1127 |
647087 | C7orf73 | SYSMH2 | Human | Oral cavity | OSCC | 4.15e-29 | 1.25e+00 | 0.2326 |
647087 | C7orf73 | SYSMH3 | Human | Oral cavity | OSCC | 5.60e-42 | 1.51e+00 | 0.2442 |
647087 | C7orf73 | SYSMH4 | Human | Oral cavity | OSCC | 4.10e-12 | 2.91e-01 | 0.1226 |
647087 | C7orf73 | SYSMH5 | Human | Oral cavity | OSCC | 5.58e-07 | 3.29e-01 | 0.0647 |
647087 | C7orf73 | SYSMH6 | Human | Oral cavity | OSCC | 3.83e-12 | 7.07e-01 | 0.1275 |
647087 | C7orf73 | Dong_P1 | Human | Prostate | Tumor | 1.24e-99 | 8.06e-01 | 0.035 |
647087 | C7orf73 | Dong_P3 | Human | Prostate | Tumor | 7.44e-56 | 6.81e-01 | 0.0278 |
647087 | C7orf73 | Dong_P4 | Human | Prostate | Tumor | 3.61e-38 | 7.85e-01 | 0.0292 |
647087 | C7orf73 | P7 | Human | Prostate | Tumor | 5.79e-15 | 6.57e-01 | -0.1025 |
647087 | C7orf73 | P9 | Human | Prostate | Tumor | 2.92e-04 | 1.72e-01 | -0.0285 |
647087 | C7orf73 | P10 | Human | Prostate | Tumor | 4.87e-09 | 3.19e-01 | -0.0902 |
647087 | C7orf73 | GSM5353217_PA_PB1A_Pool_2_S107_L004 | Human | Prostate | Tumor | 3.83e-03 | 5.45e-01 | 0.156 |
647087 | C7orf73 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 4.09e-03 | 1.69e-01 | 0.1621 |
647087 | C7orf73 | P1_S1_AK | Human | Skin | AK | 9.75e-06 | -2.20e-01 | -0.3399 |
647087 | C7orf73 | P2_S3_AK | Human | Skin | AK | 4.56e-06 | -2.20e-01 | -0.3287 |
647087 | C7orf73 | P2_S4_SCCIS | Human | Skin | SCCIS | 4.56e-06 | -2.20e-01 | -0.3043 |
647087 | C7orf73 | P3_S6_AK | Human | Skin | AK | 9.75e-06 | -2.20e-01 | -0.3256 |
647087 | C7orf73 | P4_S8_cSCC | Human | Skin | cSCC | 3.66e-03 | -2.20e-01 | -0.3095 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C7orf73 | SNV | Missense_Mutation | novel | c.60G>T | p.Gln20His | p.Q20H | E0CX11 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.977) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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