|
Gene: C1orf21 |
Gene summary for C1ORF21 |
Gene summary. |
Gene information | Species | Human | Gene symbol | C1orf21 | Gene ID | 81563 |
Gene name | chromosome 1 open reading frame 21 | |
Gene Alias | PIG13 | |
Cytomap | 1q25.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A0A024R926 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81563 | C1orf21 | P107T-E | Human | Esophagus | ESCC | 4.33e-38 | 9.92e-01 | 0.171 |
81563 | C1orf21 | P127T-E | Human | Esophagus | ESCC | 9.45e-16 | 7.85e-02 | 0.0826 |
81563 | C1orf21 | P130T-E | Human | Esophagus | ESCC | 1.07e-25 | 9.45e-01 | 0.1676 |
81563 | C1orf21 | RNA-P10T2-P10T2-1 | Human | Lung | AAH | 1.85e-03 | 8.10e-01 | -0.1271 |
81563 | C1orf21 | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 4.67e-06 | 8.25e-01 | -0.1406 |
81563 | C1orf21 | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 1.00e-06 | 7.84e-01 | -0.1408 |
81563 | C1orf21 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 1.34e-06 | 9.67e-01 | -0.138 |
81563 | C1orf21 | RNA-P17T-P17T-4 | Human | Lung | IAC | 2.42e-03 | 1.97e-03 | 0.343 |
81563 | C1orf21 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.08e-19 | 9.99e-01 | -0.2116 |
81563 | C1orf21 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 3.04e-09 | 8.76e-01 | -0.1941 |
81563 | C1orf21 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 6.51e-13 | 9.92e-01 | -0.2107 |
81563 | C1orf21 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 3.11e-21 | 1.03e+00 | -0.2119 |
81563 | C1orf21 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 4.30e-11 | 3.40e-01 | -0.0166 |
81563 | C1orf21 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 6.02e-12 | 2.94e-01 | -0.0132 |
81563 | C1orf21 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 4.15e-15 | 3.25e-01 | -0.013 |
81563 | C1orf21 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 2.25e-05 | 2.32e-01 | -0.0121 |
81563 | C1orf21 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 2.52e-07 | 6.88e-01 | -0.0961 |
81563 | C1orf21 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 6.19e-06 | 5.89e-01 | -0.0876 |
81563 | C1orf21 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 6.59e-04 | 5.21e-01 | -0.0822 |
81563 | C1orf21 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 8.99e-05 | 4.60e-01 | -0.0809 |
Page: 1 2 3 4 5 6 7 8 9 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C1orf21 | SNV | Missense_Mutation | c.349N>C | p.Glu117Gln | p.E117Q | Q9H246 | protein_coding | tolerated(0.06) | possibly_damaging(0.607) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
C1orf21 | SNV | Missense_Mutation | c.310N>T | p.Asp104Tyr | p.D104Y | Q9H246 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-C5-A2LT-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
C1orf21 | SNV | Missense_Mutation | c.14N>T | p.Ser5Phe | p.S5F | Q9H246 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-LP-A4AX-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
C1orf21 | SNV | Missense_Mutation | c.242G>A | p.Gly81Glu | p.G81E | Q9H246 | protein_coding | deleterious(0.01) | probably_damaging(0.988) | TCGA-A6-2681-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
C1orf21 | SNV | Missense_Mutation | c.314A>G | p.Glu105Gly | p.E105G | Q9H246 | protein_coding | deleterious(0) | benign(0.025) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
C1orf21 | SNV | Missense_Mutation | c.28N>A | p.Ala10Thr | p.A10T | Q9H246 | protein_coding | deleterious(0.01) | benign(0.015) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
C1orf21 | SNV | Missense_Mutation | novel | c.317A>G | p.Lys106Arg | p.K106R | Q9H246 | protein_coding | deleterious(0) | possibly_damaging(0.801) | TCGA-AG-3726-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1orf21 | SNV | Missense_Mutation | novel | c.200N>T | p.Ala67Val | p.A67V | Q9H246 | protein_coding | tolerated(0.09) | benign(0.001) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
C1orf21 | SNV | Missense_Mutation | c.250N>T | p.His84Tyr | p.H84Y | Q9H246 | protein_coding | tolerated(0.31) | possibly_damaging(0.607) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C1orf21 | SNV | Missense_Mutation | c.297N>A | p.Phe99Leu | p.F99L | Q9H246 | protein_coding | deleterious(0.01) | possibly_damaging(0.682) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |