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Gene: BABAM1 |
Gene summary for BABAM1 |
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Gene information | Species | Human | Gene symbol | BABAM1 | Gene ID | 29086 |
Gene name | BRISC and BRCA1 A complex member 1 | |
Gene Alias | C19orf62 | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | GO:0000075 | UniProtAcc | A0A024R7L2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29086 | BABAM1 | cirrhotic1 | Human | Liver | Cirrhotic | 2.65e-11 | 1.70e-01 | 0.0202 |
29086 | BABAM1 | cirrhotic2 | Human | Liver | Cirrhotic | 2.82e-12 | 2.27e-01 | 0.0201 |
29086 | BABAM1 | cirrhotic3 | Human | Liver | Cirrhotic | 5.16e-08 | 1.96e-01 | 0.0215 |
29086 | BABAM1 | HCC1 | Human | Liver | HCC | 1.88e-04 | 3.60e+00 | 0.5336 |
29086 | BABAM1 | HCC2 | Human | Liver | HCC | 1.09e-09 | 3.49e+00 | 0.5341 |
29086 | BABAM1 | Pt13.b | Human | Liver | HCC | 1.16e-18 | 2.74e-01 | 0.0251 |
29086 | BABAM1 | Pt14.a | Human | Liver | HCC | 4.01e-06 | 3.29e-01 | 0.0169 |
29086 | BABAM1 | Pt14.b | Human | Liver | HCC | 2.92e-13 | 4.48e-01 | 0.018 |
29086 | BABAM1 | Pt14.d | Human | Liver | HCC | 4.28e-02 | 1.82e-01 | 0.0143 |
29086 | BABAM1 | S014 | Human | Liver | HCC | 4.56e-39 | 1.20e+00 | 0.2254 |
29086 | BABAM1 | S015 | Human | Liver | HCC | 1.04e-14 | 8.76e-01 | 0.2375 |
29086 | BABAM1 | S016 | Human | Liver | HCC | 5.39e-19 | 6.58e-01 | 0.2243 |
29086 | BABAM1 | S027 | Human | Liver | HCC | 6.39e-04 | 6.07e-01 | 0.2446 |
29086 | BABAM1 | S028 | Human | Liver | HCC | 7.31e-13 | 6.77e-01 | 0.2503 |
29086 | BABAM1 | S029 | Human | Liver | HCC | 1.41e-17 | 1.05e+00 | 0.2581 |
29086 | BABAM1 | C04 | Human | Oral cavity | OSCC | 6.50e-29 | 1.43e+00 | 0.2633 |
29086 | BABAM1 | C21 | Human | Oral cavity | OSCC | 1.07e-33 | 1.23e+00 | 0.2678 |
29086 | BABAM1 | C30 | Human | Oral cavity | OSCC | 1.17e-50 | 2.27e+00 | 0.3055 |
29086 | BABAM1 | C38 | Human | Oral cavity | OSCC | 4.68e-08 | 1.13e+00 | 0.172 |
29086 | BABAM1 | C43 | Human | Oral cavity | OSCC | 3.57e-82 | 1.42e+00 | 0.1704 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00093148 | Breast | Precancer | response to radiation | 47/1080 | 456/18723 | 8.39e-05 | 1.62e-03 | 47 |
GO:00102125 | Breast | Precancer | response to ionizing radiation | 21/1080 | 148/18723 | 1.19e-04 | 2.13e-03 | 21 |
GO:00510548 | Breast | Precancer | positive regulation of DNA metabolic process | 23/1080 | 201/18723 | 1.34e-03 | 1.41e-02 | 23 |
GO:20010208 | Breast | Precancer | regulation of response to DNA damage stimulus | 24/1080 | 219/18723 | 1.93e-03 | 1.87e-02 | 24 |
GO:001021213 | Breast | IDC | response to ionizing radiation | 28/1434 | 148/18723 | 6.85e-06 | 2.09e-04 | 28 |
GO:000931412 | Breast | IDC | response to radiation | 62/1434 | 456/18723 | 6.91e-06 | 2.10e-04 | 62 |
GO:200102013 | Breast | IDC | regulation of response to DNA damage stimulus | 30/1434 | 219/18723 | 1.36e-03 | 1.40e-02 | 30 |
GO:00073465 | Breast | IDC | regulation of mitotic cell cycle | 51/1434 | 457/18723 | 4.30e-03 | 3.35e-02 | 51 |
GO:000931422 | Breast | DCIS | response to radiation | 62/1390 | 456/18723 | 2.56e-06 | 8.87e-05 | 62 |
GO:001021223 | Breast | DCIS | response to ionizing radiation | 28/1390 | 148/18723 | 3.79e-06 | 1.16e-04 | 28 |
GO:200102023 | Breast | DCIS | regulation of response to DNA damage stimulus | 30/1390 | 219/18723 | 8.32e-04 | 9.47e-03 | 30 |
GO:000734612 | Breast | DCIS | regulation of mitotic cell cycle | 52/1390 | 457/18723 | 1.38e-03 | 1.43e-02 | 52 |
GO:00447724 | Breast | DCIS | mitotic cell cycle phase transition | 46/1390 | 424/18723 | 6.16e-03 | 4.39e-02 | 46 |
GO:0051052 | Colorectum | AD | regulation of DNA metabolic process | 116/3918 | 359/18723 | 2.47e-07 | 1.00e-05 | 116 |
GO:0051054 | Colorectum | AD | positive regulation of DNA metabolic process | 73/3918 | 201/18723 | 3.27e-07 | 1.29e-05 | 73 |
GO:2001020 | Colorectum | AD | regulation of response to DNA damage stimulus | 71/3918 | 219/18723 | 4.38e-05 | 7.65e-04 | 71 |
GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
GO:2001022 | Colorectum | AD | positive regulation of response to DNA damage stimulus | 36/3918 | 105/18723 | 1.02e-03 | 9.47e-03 | 36 |
GO:0006282 | Colorectum | AD | regulation of DNA repair | 42/3918 | 130/18723 | 1.57e-03 | 1.32e-02 | 42 |
GO:0007346 | Colorectum | AD | regulation of mitotic cell cycle | 119/3918 | 457/18723 | 4.60e-03 | 3.14e-02 | 119 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BABAM1 | SNV | Missense_Mutation | novel | c.530N>T | p.Ser177Phe | p.S177F | Q9NWV8 | protein_coding | tolerated(0.05) | benign(0.221) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BABAM1 | SNV | Missense_Mutation | novel | c.554N>C | p.Gly185Ala | p.G185A | Q9NWV8 | protein_coding | tolerated(0.2) | benign(0.015) | TCGA-A6-3808-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
BABAM1 | SNV | Missense_Mutation | c.491N>A | p.Arg164His | p.R164H | Q9NWV8 | protein_coding | deleterious(0.04) | probably_damaging(0.954) | TCGA-CM-4752-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
BABAM1 | SNV | Missense_Mutation | rs375274426 | c.655N>T | p.Arg219Cys | p.R219C | Q9NWV8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DM-A0XD-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
BABAM1 | SNV | Missense_Mutation | c.59N>T | p.Ser20Leu | p.S20L | Q9NWV8 | protein_coding | tolerated_low_confidence(0.48) | benign(0) | TCGA-F4-6808-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BABAM1 | SNV | Missense_Mutation | rs758526214 | c.77G>A | p.Arg26His | p.R26H | Q9NWV8 | protein_coding | tolerated_low_confidence(0.1) | benign(0.001) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BABAM1 | SNV | Missense_Mutation | rs765161255 | c.524C>T | p.Thr175Met | p.T175M | Q9NWV8 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
BABAM1 | SNV | Missense_Mutation | c.526N>A | p.Ala176Thr | p.A176T | Q9NWV8 | protein_coding | tolerated(0.55) | benign(0.234) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BABAM1 | SNV | Missense_Mutation | novel | c.400N>G | p.Thr134Ala | p.T134A | Q9NWV8 | protein_coding | tolerated(0.17) | possibly_damaging(0.731) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BABAM1 | SNV | Missense_Mutation | novel | c.850C>A | p.Leu284Met | p.L284M | Q9NWV8 | protein_coding | tolerated(0.15) | benign(0.073) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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