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Gene: ATOX1 |
Gene summary for ATOX1 |
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Gene information | Species | Human | Gene symbol | ATOX1 | Gene ID | 475 |
Gene name | antioxidant 1 copper chaperone | |
Gene Alias | ATX1 | |
Cytomap | 5q33.1 | |
Gene Type | protein-coding | GO ID | GO:0000041 | UniProtAcc | O00244 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
475 | ATOX1 | P39T-E | Human | Esophagus | ESCC | 6.03e-14 | 2.81e-01 | 0.0894 |
475 | ATOX1 | P40T-E | Human | Esophagus | ESCC | 4.42e-24 | 8.63e-01 | 0.109 |
475 | ATOX1 | P42T-E | Human | Esophagus | ESCC | 2.36e-24 | 8.58e-01 | 0.1175 |
475 | ATOX1 | P44T-E | Human | Esophagus | ESCC | 3.29e-25 | 9.87e-01 | 0.1096 |
475 | ATOX1 | P47T-E | Human | Esophagus | ESCC | 6.05e-27 | 6.52e-01 | 0.1067 |
475 | ATOX1 | P48T-E | Human | Esophagus | ESCC | 4.70e-19 | 4.59e-01 | 0.0959 |
475 | ATOX1 | P49T-E | Human | Esophagus | ESCC | 3.41e-21 | 2.23e+00 | 0.1768 |
475 | ATOX1 | P52T-E | Human | Esophagus | ESCC | 1.31e-85 | 1.82e+00 | 0.1555 |
475 | ATOX1 | P54T-E | Human | Esophagus | ESCC | 1.45e-17 | 5.06e-01 | 0.0975 |
475 | ATOX1 | P56T-E | Human | Esophagus | ESCC | 1.00e-12 | 1.74e+00 | 0.1613 |
475 | ATOX1 | P57T-E | Human | Esophagus | ESCC | 1.96e-26 | 5.00e-01 | 0.0926 |
475 | ATOX1 | P61T-E | Human | Esophagus | ESCC | 1.97e-21 | 5.98e-01 | 0.099 |
475 | ATOX1 | P62T-E | Human | Esophagus | ESCC | 2.90e-72 | 1.56e+00 | 0.1302 |
475 | ATOX1 | P65T-E | Human | Esophagus | ESCC | 7.28e-25 | 6.42e-01 | 0.0978 |
475 | ATOX1 | P74T-E | Human | Esophagus | ESCC | 2.75e-31 | 9.79e-01 | 0.1479 |
475 | ATOX1 | P75T-E | Human | Esophagus | ESCC | 4.05e-59 | 1.32e+00 | 0.1125 |
475 | ATOX1 | P76T-E | Human | Esophagus | ESCC | 7.03e-47 | 1.00e+00 | 0.1207 |
475 | ATOX1 | P79T-E | Human | Esophagus | ESCC | 4.59e-43 | 9.14e-01 | 0.1154 |
475 | ATOX1 | P80T-E | Human | Esophagus | ESCC | 2.57e-61 | 2.17e+00 | 0.155 |
475 | ATOX1 | P82T-E | Human | Esophagus | ESCC | 2.55e-28 | 1.40e+00 | 0.1072 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00000412 | Breast | Precancer | transition metal ion transport | 13/1080 | 105/18723 | 7.35e-03 | 4.89e-02 | 13 |
GO:0070839 | Breast | IDC | metal ion export | 10/1434 | 54/18723 | 7.22e-03 | 4.96e-02 | 10 |
GO:00708391 | Breast | DCIS | metal ion export | 10/1390 | 54/18723 | 5.83e-03 | 4.18e-02 | 10 |
GO:00000411 | Liver | HCC | transition metal ion transport | 59/7958 | 105/18723 | 3.18e-03 | 1.47e-02 | 59 |
GO:0006825 | Prostate | BPH | copper ion transport | 7/3107 | 15/18723 | 6.42e-03 | 2.91e-02 | 7 |
GO:00068251 | Prostate | Tumor | copper ion transport | 7/3246 | 15/18723 | 8.22e-03 | 3.60e-02 | 7 |
GO:0000041 | Stomach | GC | transition metal ion transport | 15/1159 | 105/18723 | 2.01e-03 | 2.03e-02 | 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0497821 | Breast | DCIS | Mineral absorption | 13/846 | 60/8465 | 5.48e-03 | 2.81e-02 | 2.07e-02 | 13 |
hsa0497831 | Breast | DCIS | Mineral absorption | 13/846 | 60/8465 | 5.48e-03 | 2.81e-02 | 2.07e-02 | 13 |
hsa0497814 | Prostate | BPH | Mineral absorption | 20/1718 | 60/8465 | 1.22e-02 | 3.61e-02 | 2.23e-02 | 20 |
hsa0497815 | Prostate | BPH | Mineral absorption | 20/1718 | 60/8465 | 1.22e-02 | 3.61e-02 | 2.23e-02 | 20 |
hsa049786 | Stomach | CAG | Mineral absorption | 8/368 | 60/8465 | 4.18e-03 | 2.94e-02 | 2.36e-02 | 8 |
hsa049787 | Stomach | CAG | Mineral absorption | 8/368 | 60/8465 | 4.18e-03 | 2.94e-02 | 2.36e-02 | 8 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATOX1 | SNV | Missense_Mutation | novel | c.52N>A | p.Ala18Thr | p.A18T | O00244 | protein_coding | tolerated(0.06) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATOX1 | SNV | Missense_Mutation | novel | c.18C>A | p.Phe6Leu | p.F6L | O00244 | protein_coding | deleterious(0.02) | probably_damaging(0.992) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ATOX1 | insertion | Frame_Shift_Ins | novel | c.111_112insCACTCCA | p.Lys38HisfsTer8 | p.K38Hfs*8 | O00244 | protein_coding | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | ||
ATOX1 | SNV | Missense_Mutation | rs752342635 | c.5N>T | p.Pro2Leu | p.P2L | O00244 | protein_coding | tolerated(0.24) | benign(0) | TCGA-G3-AAV4-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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